BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

598 related articles for article (PubMed ID: 10656818)

  • 1. Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides.
    Knappik A; Ge L; Honegger A; Pack P; Fischer M; Wellnhofer G; Hoess A; Wölle J; Plückthun A; Virnekäs B
    J Mol Biol; 2000 Feb; 296(1):57-86. PubMed ID: 10656818
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.
    Rothe C; Urlinger S; Löhning C; Prassler J; Stark Y; Jäger U; Hubner B; Bardroff M; Pradel I; Boss M; Bittlingmaier R; Bataa T; Frisch C; Brocks B; Honegger A; Urban M
    J Mol Biol; 2008 Feb; 376(4):1182-200. PubMed ID: 18191144
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-based improvement of the biophysical properties of immunoglobulin VH domains with a generalizable approach.
    Ewert S; Honegger A; Plückthun A
    Biochemistry; 2003 Feb; 42(6):1517-28. PubMed ID: 12578364
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent.
    Beiboer SH; Reurs A; Roovers RC; Arends JW; Whitelegg NR; Rees AR; Hoogenboom HR
    J Mol Biol; 2000 Feb; 296(3):833-49. PubMed ID: 10677285
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Analysis of the horse V(H) repertoire and comparison with the human IGHV germline genes, and sheep, cattle and pig V(H) sequences.
    Almagro JC; Martinez L; Smith SL; Alagon A; Estevez J; Paniagua J
    Mol Immunol; 2006 Apr; 43(11):1836-45. PubMed ID: 16337682
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A semi-synthetic repertoire of intrinsically stable antibody fragments derived from a single-framework scaffold.
    Desiderio A; Franconi R; Lopez M; Villani ME; Viti F; Chiaraluce R; Consalvi V; Neri D; Benvenuto E
    J Mol Biol; 2001 Jul; 310(3):603-15. PubMed ID: 11439027
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and validation of a synthetic VH repertoire with tailored diversity for protein recognition.
    Almagro JC; Quintero-Hernández V; Ortiz-León M; Velandia A; Smith SL; Becerril B
    J Mol Recognit; 2006; 19(5):413-22. PubMed ID: 16881059
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A germline knowledge based computational approach for determining antibody complementarity determining regions.
    Zhao S; Lu J
    Mol Immunol; 2010 Jan; 47(4):694-700. PubMed ID: 19939452
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Building novel binding ligands to B7.1 and B7.2 based on human antibody single variable light chain domains.
    van den Beucken T; van Neer N; Sablon E; Desmet J; Celis L; Hoogenboom HR; Hufton SE
    J Mol Biol; 2001 Jul; 310(3):591-601. PubMed ID: 11439026
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions.
    Sidhu SS; Li B; Chen Y; Fellouse FA; Eigenbrot C; Fuh G
    J Mol Biol; 2004 Apr; 338(2):299-310. PubMed ID: 15066433
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Improvement of anti-Burkholderia mouse monoclonal antibody from various phage-displayed single-chain antibody libraries.
    Kim HS; Lo SC; Wear DJ; Stojadinovic A; Weina PJ; Izadjoo MJ
    J Immunol Methods; 2011 Sep; 372(1-2):146-61. PubMed ID: 21787781
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues.
    Wu H; Nie Y; Huse WD; Watkins JD
    J Mol Biol; 1999 Nov; 294(1):151-62. PubMed ID: 10556035
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The imprint of somatic hypermutation on the repertoire of human germline V genes.
    Tomlinson IM; Walter G; Jones PT; Dear PH; Sonnhammer EL; Winter G
    J Mol Biol; 1996 Mar; 256(5):813-17. PubMed ID: 8601832
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains.
    Honegger A; Malebranche AD; Röthlisberger D; Plückthun A
    Protein Eng Des Sel; 2009 Mar; 22(3):121-34. PubMed ID: 19136675
    [TBL] [Abstract][Full Text] [Related]  

  • 15. High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold.
    Lee CV; Liang WC; Dennis MS; Eigenbrot C; Sidhu SS; Fuh G
    J Mol Biol; 2004 Jul; 340(5):1073-93. PubMed ID: 15236968
    [TBL] [Abstract][Full Text] [Related]  

  • 16. HuCAL PLATINUM, a synthetic Fab library optimized for sequence diversity and superior performance in mammalian expression systems.
    Prassler J; Thiel S; Pracht C; Polzer A; Peters S; Bauer M; Nörenberg S; Stark Y; Kölln J; Popp A; Urlinger S; Enzelberger M
    J Mol Biol; 2011 Oct; 413(1):261-78. PubMed ID: 21856311
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Affinity maturation of a V(H)H by mutational hotspot randomization.
    Yau KY; Dubuc G; Li S; Hirama T; Mackenzie CR; Jermutus L; Hall JC; Tanha J
    J Immunol Methods; 2005 Feb; 297(1-2):213-24. PubMed ID: 15777944
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Expanding the conformational diversity by random insertions to CDRH2 results in improved anti-estradiol antibodies.
    Lamminmäki U; Paupério S; Westerlund-Karlsson A; Karvinen J; Virtanen PL; Lövgren T; Saviranta P
    J Mol Biol; 1999 Aug; 291(3):589-602. PubMed ID: 10448039
    [TBL] [Abstract][Full Text] [Related]  

  • 19. [Cloning of the variable region genes from hybridoma against bFGF and expression of single chain antibody fragments in E.coli HB2151].
    Wang H; Chen D; Deng N; Xiang JJ; Jin YJ; Huang HL; Tang Y; Yang HY
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2007 Dec; 23(12):1150-3. PubMed ID: 18062890
    [TBL] [Abstract][Full Text] [Related]  

  • 20. [Generation of anti-rhEPO ScFv by using phage display technology].
    Zhong L; Wu S; Yang X
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi; 1998 Mar; 12(1):38-42. PubMed ID: 12515169
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 30.