BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

519 related articles for article (PubMed ID: 10688911)

  • 1. Mammalian thioredoxin reductase: oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity.
    Lee SR; Bar-Noy S; Kwon J; Levine RL; Stadtman TC; Rhee SG
    Proc Natl Acad Sci U S A; 2000 Mar; 97(6):2521-6. PubMed ID: 10688911
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Effects of buried charged groups on cysteine thiol ionization and reactivity in Escherichia coli thioredoxin: structural and functional characterization of mutants of Asp 26 and Lys 57.
    Dyson HJ; Jeng MF; Tennant LL; Slaby I; Lindell M; Cui DS; Kuprin S; Holmgren A
    Biochemistry; 1997 Mar; 36(9):2622-36. PubMed ID: 9054569
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Thioredoxin reductase from Plasmodium falciparum: evidence for interaction between the C-terminal cysteine residues and the active site disulfide-dithiol.
    Wang PF; Arscott LD; Gilberger TW; Müller S; Williams CH
    Biochemistry; 1999 Mar; 38(10):3187-96. PubMed ID: 10074374
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis.
    Waksman G; Krishna TS; Williams CH; Kuriyan J
    J Mol Biol; 1994 Feb; 236(3):800-16. PubMed ID: 8114095
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Human selenium-dependent thioredoxin reductase from HeLa cells: properties of forms with differing heparin affinities.
    Gorlatov SN; Stadtman TC
    Arch Biochem Biophys; 1999 Sep; 369(1):133-42. PubMed ID: 10462449
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence.
    Zhong L; Arnér ES; Holmgren A
    Proc Natl Acad Sci U S A; 2000 May; 97(11):5854-9. PubMed ID: 10801974
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations.
    Zhong L; Holmgren A
    J Biol Chem; 2000 Jun; 275(24):18121-8. PubMed ID: 10849437
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Function of Glu-469' in the acid-base catalysis of thioredoxin reductase from Drosophila melanogaster.
    Huang HH; Arscott LD; Ballou DP; Williams CH
    Biochemistry; 2008 Dec; 47(48):12769-76. PubMed ID: 18991392
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Human thioredoxin reductase from HeLa cells: selective alkylation of selenocysteine in the protein inhibits enzyme activity and reduction with NADPH influences affinity to heparin.
    Gorlatov SN; Stadtman TC
    Proc Natl Acad Sci U S A; 1998 Jul; 95(15):8520-5. PubMed ID: 9671710
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Studies of an active site mutant of the selenoprotein thioredoxin reductase: the Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme.
    Johansson L; Arscott LD; Ballou DP; Williams CH; Arnér ES
    Free Radic Biol Med; 2006 Aug; 41(4):649-56. PubMed ID: 16863998
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme.
    Sandalova T; Zhong L; Lindqvist Y; Holmgren A; Schneider G
    Proc Natl Acad Sci U S A; 2001 Aug; 98(17):9533-8. PubMed ID: 11481439
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Oxidation of thioredoxin reductase in HeLa cells stimulated with tumor necrosis factor-alpha.
    Kim JR; Lee SM; Cho SH; Kim JH; Kim BH; Kwon J; Choi CY; Kim YD; Lee SR
    FEBS Lett; 2004 Jun; 567(2-3):189-96. PubMed ID: 15178321
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Overexpression of wild type and SeCys/Cys mutant of human thioredoxin reductase in E. coli: the role of selenocysteine in the catalytic activity.
    Bar-Noy S; Gorlatov SN; Stadtman TC
    Free Radic Biol Med; 2001 Jan; 30(1):51-61. PubMed ID: 11134895
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Selenium as an electron acceptor during the catalytic mechanism of thioredoxin reductase.
    Lothrop AP; Snider GW; Ruggles EL; Patel AS; Lees WJ; Hondal RJ
    Biochemistry; 2014 Feb; 53(4):654-63. PubMed ID: 24422500
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Antioxidant function of thioredoxin and glutaredoxin systems.
    Holmgren A
    Antioxid Redox Signal; 2000; 2(4):811-20. PubMed ID: 11213485
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Why selenocysteine replaces cysteine in thioredoxin reductase: a radical hypothesis.
    Nauser T; Steinmann D; Grassi G; Koppenol WH
    Biochemistry; 2014 Aug; 53(30):5017-22. PubMed ID: 24999795
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The mutual sparing effects of selenium and vitamin E in animal nutrition may be further explained by the discovery that mammalian thioredoxin reductase is a selenoenzyme.
    Tamura T; Gladyshev V; Liu SY; Stadtman TC
    Biofactors; 1995-1996; 5(2):99-102. PubMed ID: 8722124
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity.
    Fang J; Lu J; Holmgren A
    J Biol Chem; 2005 Jul; 280(26):25284-90. PubMed ID: 15879598
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Acid-base catalysis in the mechanism of thioredoxin reductase from Drosophila melanogaster.
    Huang HH; Arscott LD; Ballou DP; Williams CH
    Biochemistry; 2008 Feb; 47(6):1721-31. PubMed ID: 18211101
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A mechanistic investigation of the C-terminal redox motif of thioredoxin reductase from Plasmodium falciparum.
    Snider GW; Dustin CM; Ruggles EL; Hondal RJ
    Biochemistry; 2014 Jan; 53(3):601-9. PubMed ID: 24400600
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 26.