BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

107 related articles for article (PubMed ID: 10692498)

  • 1. A steroid derivative with paclitaxel-like effects on tubulin polymerization.
    Verdier-Pinard P; Wang Z; Mohanakrishnan AK; Cushman M; Hamel E
    Mol Pharmacol; 2000 Mar; 57(3):568-75. PubMed ID: 10692498
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.
    Cushman M; He HM; Katzenellenbogen JA; Lin CM; Hamel E
    J Med Chem; 1995 Jun; 38(12):2041-9. PubMed ID: 7783135
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability.
    Wang Z; Yang D; Mohanakrishnan AK; Fanwick PE; Nampoothiri P; Hamel E; Cushman M
    J Med Chem; 2000 Jun; 43(12):2419-29. PubMed ID: 10882369
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Estradiol dimer inhibits tubulin polymerization and microtubule dynamics.
    Jurášek M; Černohorská M; Řehulka J; Spiwok V; Sulimenko T; Dráberová E; Darmostuk M; Gurská S; Frydrych I; Buriánová R; Ruml T; Hajdúch M; Bartůněk P; Dráber P; Džubák P; Drašar PB; Sedlák D
    J Steroid Biochem Mol Biol; 2018 Oct; 183():68-79. PubMed ID: 29803726
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth.
    Cushman M; He HM; Katzenellenbogen JA; Varma RK; Hamel E; Lin CM; Ram S; Sachdeva YP
    J Med Chem; 1997 Jul; 40(15):2323-34. PubMed ID: 9240348
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.
    D'Amato RJ; Lin CM; Flynn E; Folkman J; Hamel E
    Proc Natl Acad Sci U S A; 1994 Apr; 91(9):3964-8. PubMed ID: 8171020
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously.
    Gapud EJ; Bai R; Ghosh AK; Hamel E
    Mol Pharmacol; 2004 Jul; 66(1):113-21. PubMed ID: 15213302
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Differential effects of paclitaxel (Taxol) analogs modified at positions C-2, C-7, and C-3' on tubulin polymerization and polymer stabilization: identification of a hyperactive paclitaxel derivative.
    Grover S; Rimoldi JM; Molinero AA; Chaudhary AG; Kingston DG; Hamel E
    Biochemistry; 1995 Mar; 34(12):3927-34. PubMed ID: 7696257
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Interactions of 2-methoxyestradiol, an endogenous mammalian metabolite, with unpolymerized tubulin and with tubulin polymers.
    Hamel E; Lin CM; Flynn E; D'Amato RJ
    Biochemistry; 1996 Jan; 35(4):1304-10. PubMed ID: 8573587
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol.
    Clark EA; Hills PM; Davidson BS; Wender PA; Mooberry SL
    Mol Pharm; 2006; 3(4):457-67. PubMed ID: 16889440
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and structure-activity profiles of A-homoestranes, the estratropones.
    Miller TA; Bulman AL; Thompson CD; Garst ME; Macdonald TL
    J Med Chem; 1997 Nov; 40(23):3836-41. PubMed ID: 9371249
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Class I beta-tubulin mutations in 2-methoxyestradiol-resistant acute lymphoblastic leukemia cells: implications for drug-target interactions.
    Liaw TY; Salam NK; McKay MJ; Cunningham AM; Hibbs DE; Kavallaris M
    Mol Cancer Ther; 2008 Oct; 7(10):3150-9. PubMed ID: 18852118
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Assessment of microtubule stabilizers by semiautomated in vitro microtubule protein polymerization and mitotic block assays.
    Lopes NM; Miller HP; Young ND; Bhuyan BK
    Cancer Chemother Pharmacol; 1997; 41(1):37-47. PubMed ID: 9443612
    [TBL] [Abstract][Full Text] [Related]  

  • 14. DTA0100, dual topoisomerase II and microtubule inhibitor, evades paclitaxel resistance in P-glycoprotein overexpressing cancer cells.
    Podolski-Renić A; Banković J; Dinić J; Ríos-Luci C; Fernandes MX; Ortega N; Kovačević-Grujičić N; Martín VS; Padrón JM; Pešić M
    Eur J Pharm Sci; 2017 Jul; 105():159-168. PubMed ID: 28502672
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The effect of exchanging various substituents at the 2-position of 2-methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization.
    Cushman M; Mohanakrishnan AK; Hollingshead M; Hamel E
    J Med Chem; 2002 Oct; 45(21):4748-54. PubMed ID: 12361402
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance.
    Yang J; Song D; Li B; Gao X; Wang Y; Li X; Bao C; Wu C; Bao Y; Waxman S; Chen G; Jing Y
    Drug Resist Updat; 2023 May; 68():100951. PubMed ID: 36841134
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization.
    Gastpar R; Goldbrunner M; Marko D; von Angerer E
    J Med Chem; 1998 Dec; 41(25):4965-72. PubMed ID: 9836614
    [TBL] [Abstract][Full Text] [Related]  

  • 18. beta-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells.
    Gökmen-Polar Y; Escuin D; Walls CD; Soule SE; Wang Y; Sanders KL; Lavallee TM; Wang M; Guenther BD; Giannakakou P; Sledge GW
    Cancer Res; 2005 Oct; 65(20):9406-14. PubMed ID: 16230404
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: inhibitors of tubulin and angiogenesis.
    Solum EJ; Cheng JJ; Sørvik IB; Paulsen RE; Vik A; Hansen TV
    Eur J Med Chem; 2014 Oct; 85():391-8. PubMed ID: 25108078
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Tubulin from paclitaxel-resistant cells as a probe for novel antimicrotubule agents.
    Sackett DL; Giannakakou P; Poruchynsky M; Fojo A
    Cancer Chemother Pharmacol; 1997; 40(3):228-32. PubMed ID: 9219506
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.