BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

98 related articles for article (PubMed ID: 10698522)

  • 1. A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.
    Blalock WL; Pearce M; Steelman LS; Franklin RA; McCarthy SA; Cherwinski H; McMahon M; McCubrey JA
    Oncogene; 2000 Jan; 19(4):526-36. PubMed ID: 10698522
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells.
    Blalock WL; Pearce M; Chang F; Lee JT; Pohnert SC; Burrows C; Steelman LS; Franklin RA; McMahon M; McCubrey JA
    Leukemia; 2001 May; 15(5):794-807. PubMed ID: 11368441
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism.
    Hoyle PE; Moye PW; Steelman LS; Blalock WL; Franklin RA; Pearce M; Cherwinski H; Bosch E; McMahon M; McCubrey JA
    Leukemia; 2000 Apr; 14(4):642-56. PubMed ID: 10764150
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.
    Blalock WL; Moye PW; Chang F; Pearce M; Steelman LS; McMahon M; McCubrey JA
    Leukemia; 2000 Jun; 14(6):1080-96. PubMed ID: 10865974
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.
    Blalock WL; Navolanic PM; Steelman LS; Shelton JG; Moye PW; Lee JT; Franklin RA; Mirza A; McMahon M; White MK; McCubrey JA
    Leukemia; 2003 Jun; 17(6):1058-67. PubMed ID: 12764369
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Ability of the activated PI3K/Akt oncoproteins to synergize with MEK1 and induce cell cycle progression and abrogate the cytokine-dependence of hematopoietic cells.
    Shelton JG; Blalock WL; White ER; Steelman LS; McCubrey JA
    Cell Cycle; 2004 Apr; 3(4):503-12. PubMed ID: 15004527
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells.
    McCubrey JA; Steelman LS; Hoyle PE; Blalock WL; Weinstein-Oppenheimer C; Franklin RA; Cherwinski H; Bosch E; McMahon M
    Leukemia; 1998 Dec; 12(12):1903-29. PubMed ID: 9844921
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells.
    Weinstein-Oppenheimer C; Steelman LS; Algate PA; Blalock WL; Burrows C; Hoyle PE; Lee JT; Moye PW; Shelton JG; Franklin R; McCubrey JA
    Leukemia; 2000 Nov; 14(11):1921-38. PubMed ID: 11069028
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for the treatment of Raf-transformed hematopoietic cells.
    Konopleva M; Shi Y; Steelman LS; Shelton JG; Munsell M; Marini F; McQueen T; Contractor R; McCubrey JA; Andreeff M
    Cancer Res; 2005 Nov; 65(21):9962-70. PubMed ID: 16267021
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation.
    Shelton JG; Moye PW; Steelman LS; Blalock WL; Lee JT; Franklin RA; McMahon M; McCubrey JA
    Leukemia; 2003 Sep; 17(9):1765-82. PubMed ID: 12970777
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Autocrine transformation of human hematopoietic cells after transfection with an activated granulocyte/macrophage colony stimulating factor gene.
    Hoyle PE; Steelman LS; McCubrey JA
    Cytokines Cell Mol Ther; 1997 Sep; 3(3):159-68. PubMed ID: 9426974
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells.
    McCubrey JA; Lee JT; Steelman LS; Blalock WL; Moye PW; Chang F; Pearce M; Shelton JG; White MK; Franklin RA; Pohnert SC
    Cancer Detect Prev; 2001; 25(4):375-93. PubMed ID: 11531015
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells.
    McCubrey JA; Shelton JG; Steelman LS; Franklin RA; Sreevalsan T; McMahon M
    Oncogene; 2004 Oct; 23(47):7810-20. PubMed ID: 15361836
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Characterization of factor-independent variants derived from TF-1 hematopoietic progenitor cells: the role of the Raf/MAP kinase pathway in the anti-apoptotic effect of GM-CSF.
    Chao JR; Chen CS; Wang TF; Tseng LH; Tsai JJ; Kuo ML; Yen JJ; Yang Yen HF
    Oncogene; 1997 Feb; 14(6):721-8. PubMed ID: 9038380
    [TBL] [Abstract][Full Text] [Related]  

  • 15. An analysis of Mek1 signaling in cell proliferation and transformation.
    Greulich H; Erikson RL
    J Biol Chem; 1998 May; 273(21):13280-8. PubMed ID: 9582373
    [TBL] [Abstract][Full Text] [Related]  

  • 16. MAP kinase/estrogen receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance.
    Atanaskova N; Keshamouni VG; Krueger JS; Schwartz JA; Miller F; Reddy KB
    Oncogene; 2002 Jun; 21(25):4000-8. PubMed ID: 12037682
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.
    McCubrey JA; Steelman LS; Abrams SL; Lee JT; Chang F; Bertrand FE; Navolanic PM; Terrian DM; Franklin RA; D'Assoro AB; Salisbury JL; Mazzarino MC; Stivala F; Libra M
    Adv Enzyme Regul; 2006; 46():249-79. PubMed ID: 16854453
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activated Raf-1 causes growth arrest in human small cell lung cancer cells.
    Ravi RK; Weber E; McMahon M; Williams JR; Baylin S; Mal A; Harter ML; Dillehay LE; Claudio PP; Giordano A; Nelkin BD; Mabry M
    J Clin Invest; 1998 Jan; 101(1):153-9. PubMed ID: 9421477
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH 3T3 cells in a MEK-dependent fashion.
    Hartkamp J; Troppmair J; Rapp UR
    Cancer Res; 1999 May; 59(9):2195-202. PubMed ID: 10232608
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway.
    Stoica GE; Franke TF; Moroni M; Mueller S; Morgan E; Iann MC; Winder AD; Reiter R; Wellstein A; Martin MB; Stoica A
    Oncogene; 2003 Sep; 22(39):7998-8011. PubMed ID: 12970748
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.