BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

295 related articles for article (PubMed ID: 10715162)

  • 1. Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (+/-)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype.
    Guzikowski AP; Tamiz AP; Acosta-Burruel M; Hong-Bae S; Cai SX; Hawkinson JE; Keana JF; Kesten SR; Shipp CT; Tran M; Whittemore ER; Woodward RM; Wright JL; Zhou ZL
    J Med Chem; 2000 Mar; 43(5):984-94. PubMed ID: 10715162
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(arylalkynyl)-4-benzylpiperidines.
    Wright JL; Gregory TF; Bigge CF; Boxer PA; Serpa K; Meltzer LT; Wise LD; Cai SX; Hawkinson JE; Konkoy CS; Whittemore ER; Woodward RM; Zhou ZL
    J Med Chem; 1999 Jul; 42(13):2469-77. PubMed ID: 10395488
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist.
    Zhou ZL; Cai SX; Whittemore ER; Konkoy CS; Espitia SA; Tran M; Rock DM; Coughenour LL; Hawkinson JE; Boxer PA; Bigge CF; Wise LD; Weber E; Woodward RM; Keana JF
    J Med Chem; 1999 Jul; 42(15):2993-3000. PubMed ID: 10425109
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines.
    Wright JL; Gregory TF; Kesten SR; Boxer PA; Serpa KA; Meltzer LT; Wise LD; Espitia SA; Konkoy CS; Whittemore ER; Woodward RM
    J Med Chem; 2000 Sep; 43(18):3408-19. PubMed ID: 10978188
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Subtype-selective antagonism of NMDA receptors by nylidrin.
    Whittemore ER; Ilyin VI; Konkoy CS; Woodward RM
    Eur J Pharmacol; 1997 Oct; 337(2-3):197-208. PubMed ID: 9430414
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists.
    Tamiz AP; Cai SX; Zhou ZL; Yuen PW; Schelkun RM; Whittemore ER; Weber E; Woodward RM; Keana JF
    J Med Chem; 1999 Aug; 42(17):3412-20. PubMed ID: 10464027
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors.
    Tamiz AP; Whittemore ER; Zhou ZL; Huang JC; Drewe JA; Chen JC; Cai SX; Weber E; Woodward RM; Keana JF
    J Med Chem; 1998 Aug; 41(18):3499-506. PubMed ID: 9719603
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.
    Cai SX; Kher SM; Zhou ZL; Ilyin V; Espitia SA; Tran M; Hawkinson JE; Woodward RM; Weber E; Keana JF
    J Med Chem; 1997 Feb; 40(5):730-8. PubMed ID: 9057859
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition.
    Whittemore ER; Ilyin VI; Woodward RM
    J Pharmacol Exp Ther; 1997 Jul; 282(1):326-38. PubMed ID: 9223571
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist.
    Pinard E; Alanine A; Bourson A; Büttelmann B; Gill R; Heitz M; Jaeschke G; Mutel V; Trube G; Wyler R
    Bioorg Med Chem Lett; 2001 Aug; 11(16):2173-6. PubMed ID: 11514163
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist.
    Gill R; Alanine A; Bourson A; Buttelmann B; Fischer G; Heitz MP; Kew JN; Levet-Trafit B; Lorez HP; Malherbe P; Miss MT; Mutel V; Pinard E; Roever S; Schmitt M; Trube G; Wybrecht R; Wyler R; Kemp JA
    J Pharmacol Exp Ther; 2002 Sep; 302(3):940-8. PubMed ID: 12183650
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.
    Williams K
    Mol Pharmacol; 1993 Oct; 44(4):851-9. PubMed ID: 7901753
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Antagonist properties of eliprodil and other NMDA receptor antagonists at rat NR1A/NR2A and NR1A/NR2B receptors expressed in Xenopus oocytes.
    Avenet P; Léonardon J; Besnard F; Graham D; Depoortere H; Scatton B
    Neurosci Lett; 1997 Feb; 223(2):133-6. PubMed ID: 9089691
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antagonist properties of the stereoisomers of ifenprodil at NR1A/NR2A and NR1A/NR2B subtypes of the NMDA receptor expressed in Xenopus oocytes.
    Avenet P; Léonardon J; Besnard F; Graham D; Frost J; Depoortere H; Langer SZ; Scatton B
    Eur J Pharmacol; 1996 Jan; 296(2):209-13. PubMed ID: 8838458
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Amino-alkyl-cyclohexanes are novel uncompetitive NMDA receptor antagonists with strong voltage-dependency and fast blocking kinetics: in vitro and in vivo characterization.
    Parsons CG; Danysz W; Bartmann A; Spielmanns P; Frankiewicz T; Hesselink M; Eilbacher B; Quack G
    Neuropharmacology; 1999 Jan; 38(1):85-108. PubMed ID: 10193901
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.
    Ilyin VI; Whittemore ER; Guastella J; Weber E; Woodward RM
    Mol Pharmacol; 1996 Dec; 50(6):1541-50. PubMed ID: 8967976
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity.
    Bigge CF; Malone TC; Boxer PA; Nelson CB; Ortwine DF; Schelkun RM; Retz DM; Lescosky LJ; Borosky SA; Vartanian MG
    J Med Chem; 1995 Sep; 38(19):3720-40. PubMed ID: 7562904
    [TBL] [Abstract][Full Text] [Related]  

  • 18. N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: a novel antagonist at the 1A/2B NMDA receptor subtype.
    Tamiz AP; Whittemore ER; Schelkun RM; Yuen PW; Woodward RM; Cai SX; Weber E; Keana JF
    Bioorg Med Chem Lett; 1998 Jan; 8(2):199-200. PubMed ID: 9871654
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites.
    Woodward RM; Huettner JE; Guastella J; Keana JF; Weber E
    Mol Pharmacol; 1995 Mar; 47(3):568-81. PubMed ID: 7700254
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites.
    Guzikowski AP; Cai SX; Espitia SA; Hawkinson JE; Huettner JE; Nogales DF; Tran M; Woodward RM; Weber E; Keana JF
    J Med Chem; 1996 Nov; 39(23):4643-53. PubMed ID: 8917653
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.