BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

284 related articles for article (PubMed ID: 10717003)

  • 1. Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease.
    Wyttenbach A; Carmichael J; Swartz J; Furlong RA; Narain Y; Rankin J; Rubinsztein DC
    Proc Natl Acad Sci U S A; 2000 Mar; 97(6):2898-903. PubMed ID: 10717003
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.
    Cummings CJ; Mancini MA; Antalffy B; DeFranco DB; Orr HT; Zoghbi HY
    Nat Genet; 1998 Jun; 19(2):148-54. PubMed ID: 9620770
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.
    Waelter S; Boeddrich A; Lurz R; Scherzinger E; Lueder G; Lehrach H; Wanker EE
    Mol Biol Cell; 2001 May; 12(5):1393-407. PubMed ID: 11359930
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease.
    Wyttenbach A; Swartz J; Kita H; Thykjaer T; Carmichael J; Bradley J; Brown R; Maxwell M; Schapira A; Orntoft TF; Kato K; Rubinsztein DC
    Hum Mol Genet; 2001 Aug; 10(17):1829-45. PubMed ID: 11532992
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity.
    Jana NR; Tanaka M; Wang Gh; Nukina N
    Hum Mol Genet; 2000 Aug; 9(13):2009-18. PubMed ID: 10942430
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro.
    Chai Y; Koppenhafer SL; Shoesmith SJ; Perez MK; Paulson HL
    Hum Mol Genet; 1999 Apr; 8(4):673-82. PubMed ID: 10072437
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone.
    Stenoien DL; Cummings CJ; Adams HP; Mancini MG; Patel K; DeMartino GN; Marcelli M; Weigel NL; Mancini MA
    Hum Mol Genet; 1999 May; 8(5):731-41. PubMed ID: 10196362
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Involvement of the ubiquitin-proteasome pathway and molecular chaperones in oculopharyngeal muscular dystrophy.
    Abu-Baker A; Messaed C; Laganiere J; Gaspar C; Brais B; Rouleau GA
    Hum Mol Genet; 2003 Oct; 12(20):2609-23. PubMed ID: 12944420
    [TBL] [Abstract][Full Text] [Related]  

  • 9. UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease.
    Ardley HC; Scott GB; Rose SA; Tan NG; Robinson PA
    J Neurochem; 2004 Jul; 90(2):379-91. PubMed ID: 15228595
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy.
    Bailey CK; Andriola IF; Kampinga HH; Merry DE
    Hum Mol Genet; 2002 Mar; 11(5):515-23. PubMed ID: 11875046
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Proteasome inhibitors suppress formation of polyglutamine-induced nuclear inclusions in cultured postmitotic neurons.
    Kim WY; Horbinski C; Sigurdson W; Higgins D
    J Neurochem; 2004 Dec; 91(5):1044-56. PubMed ID: 15569248
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins.
    Ding Q; Keller JN
    J Neurochem; 2001 May; 77(4):1010-7. PubMed ID: 11359866
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release.
    Jana NR; Zemskov EA; Wang Gh ; Nukina N
    Hum Mol Genet; 2001 May; 10(10):1049-59. PubMed ID: 11331615
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.
    Martín-Aparicio E; Yamamoto A; Hernández F; Hen R; Avila J; Lucas JJ
    J Neurosci; 2001 Nov; 21(22):8772-81. PubMed ID: 11698589
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease.
    Sittler A; Lurz R; Lueder G; Priller J; Lehrach H; Hayer-Hartl MK; Hartl FU; Wanker EE
    Hum Mol Genet; 2001 Jun; 10(12):1307-15. PubMed ID: 11406612
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.
    Goswami A; Dikshit P; Mishra A; Mulherkar S; Nukina N; Jana NR
    Biochem Biophys Res Commun; 2006 Mar; 342(1):184-90. PubMed ID: 16472774
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease.
    Howarth JL; Kelly S; Keasey MP; Glover CP; Lee YB; Mitrophanous K; Chapple JP; Gallo JM; Cheetham ME; Uney JB
    Mol Ther; 2007 Jun; 15(6):1100-5. PubMed ID: 17426712
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Proteasome inhibitors differentially affect heat shock protein response in cancer cells.
    Ashok BT; Kim E; Mittelman A; Tiwari RK
    Int J Mol Med; 2001 Oct; 8(4):385-90. PubMed ID: 11562776
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance.
    Bush KT; Goldberg AL; Nigam SK
    J Biol Chem; 1997 Apr; 272(14):9086-92. PubMed ID: 9083035
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease.
    Chai Y; Koppenhafer SL; Bonini NM; Paulson HL
    J Neurosci; 1999 Dec; 19(23):10338-47. PubMed ID: 10575031
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.