BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

113 related articles for article (PubMed ID: 10743948)

  • 1. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents.
    Ryu CK; Kang HY; Lee SK; Nam KA; Hong CY; Ko WG; Lee BH
    Bioorg Med Chem Lett; 2000 Mar; 10(5):461-4. PubMed ID: 10743948
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Modulation of Nad(P)H:quinone oxidoreductase (NQO1) activity mediated by 5-arylamino-2-methyl-4,7-dioxobenzothiazoles and their cytotoxic potential.
    Ryu CK; Jeong HJ; Lee SK; Kang HY; Ko KM; Sun YJ; Song EH; Hur YH; Lee CO
    Arch Pharm Res; 2000 Dec; 23(6):554-8. PubMed ID: 11156173
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 2-Aminoquinazoline inhibitors of cyclin-dependent kinases.
    Bathini Y; Singh I; Harvey PJ; Keller PR; Singh R; Micetich RG; Fry DW; Dobrusin EM; Toogood PL
    Bioorg Med Chem Lett; 2005 Sep; 15(17):3881-5. PubMed ID: 15993068
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors.
    Zhu G; Conner SE; Zhou X; Shih C; Li T; Anderson BD; Brooks HB; Campbell RM; Considine E; Dempsey JA; Faul MM; Ogg C; Patel B; Schultz RM; Spencer CD; Teicher B; Watkins SA
    J Med Chem; 2003 May; 46(11):2027-30. PubMed ID: 12747775
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors.
    Zhu G; Conner S; Zhou X; Shih C; Brooks HB; Considine E; Dempsey JA; Ogg C; Patel B; Schultz RM; Spencer CD; Teicher B; Watkins SA
    Bioorg Med Chem Lett; 2003 Apr; 13(7):1231-5. PubMed ID: 12657252
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases.
    Misra RN; Xiao HY; Williams DK; Kim KS; Lu S; Keller KA; Mulheron JG; Batorsky R; Tokarski JS; Sack JS; Kimball SD; Lee FY; Webster KR
    Bioorg Med Chem Lett; 2004 Jun; 14(11):2973-7. PubMed ID: 15125971
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.
    Engler TA; Furness K; Malhotra S; Sanchez-Martinez C; Shih C; Xie W; Zhu G; Zhou X; Conner S; Faul MM; Sullivan KA; Kolis SP; Brooks HB; Patel B; Schultz RM; DeHahn TB; Kirmani K; Spencer CD; Watkins SA; Considine EL; Dempsey JA; Ogg CA; Stamm NB; Anderson BD; Campbell RM; Vasudevan V; Lytle ML
    Bioorg Med Chem Lett; 2003 Jul; 13(14):2261-7. PubMed ID: 12824014
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4.
    Kubo A; Nakagawa K; Varma RK; Conrad NK; Cheng JQ; Lee WC; Testa JR; Johnson BE; Kaye FJ; Kelley MJ
    Clin Cancer Res; 1999 Dec; 5(12):4279-86. PubMed ID: 10632371
    [TBL] [Abstract][Full Text] [Related]  

  • 9. New fascaplysin-based CDK4-specific inhibitors: design, synthesis and biological activity.
    Aubry C; Jenkins PR; Mahale S; Chaudhuri B; Maréchal JD; Sutcliffe MJ
    Chem Commun (Camb); 2004 Aug; (15):1696-7. PubMed ID: 15278142
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.
    Kim KS; Kimball SD; Misra RN; Rawlins DB; Hunt JT; Xiao HY; Lu S; Qian L; Han WC; Shan W; Mitt T; Cai ZW; Poss MA; Zhu H; Sack JS; Tokarski JS; Chang CY; Pavletich N; Kamath A; Humphreys WG; Marathe P; Bursuker I; Kellar KA; Roongta U; Batorsky R; Mulheron JG; Bol D; Fairchild CR; Lee FY; Webster KR
    J Med Chem; 2002 Aug; 45(18):3905-27. PubMed ID: 12190313
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines.
    Ryu CK; Kang HY; Yi YJ; Lee CO
    Arch Pharm Res; 2000 Feb; 23(1):42-5. PubMed ID: 10728655
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1.
    Jeong HW; Kim MR; Son KH; Han MY; Ha JH; Garnier M; Meijer L; Kwon BM
    Bioorg Med Chem Lett; 2000 Aug; 10(16):1819-22. PubMed ID: 10969976
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern.
    Nugiel DA; Vidwans A; Etzkorn AM; Rossi KA; Benfield PA; Burton CR; Cox S; Doleniak D; Seitz SP
    J Med Chem; 2002 Nov; 45(24):5224-32. PubMed ID: 12431050
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects.
    Kim KS; Sack JS; Tokarski JS; Qian L; Chao ST; Leith L; Kelly YF; Misra RN; Hunt JT; Kimball SD; Humphreys WG; Wautlet BS; Mulheron JG; Webster KR
    J Med Chem; 2000 Nov; 43(22):4126-34. PubMed ID: 11063609
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthetic approaches to indolo[6,7-a]pyrrolo[3,4-c]carbazoles: potent cyclin D1/CDK4 inhibitors.
    Faul MM; Engler TA; Sullivan KA; Grutsch JL; Clayton MT; Martinelli MJ; Pawlak JM; LeTourneau M; Coffey DS; Pedersen SW; Kolis SP; Furness K; Malhotra S; Al-awar RS; Ray JE
    J Org Chem; 2004 Apr; 69(9):2967-75. PubMed ID: 15104433
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-bis anilino pyrimidines.
    Beattie JF; Breault GA; Ellston RP; Green S; Jewsbury PJ; Midgley CJ; Naven RT; Minshull CA; Pauptit RA; Tucker JA; Pease JE
    Bioorg Med Chem Lett; 2003 Sep; 13(18):2955-60. PubMed ID: 12941311
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and antifungal activity of 6-arylthio-/6-arylamino-4,7-dioxobenzothiazoles.
    Ryu CK; Choi KU; Shim JY; You HJ; Choi IH; Chae MJ
    Bioorg Med Chem; 2003 Sep; 11(18):4003-8. PubMed ID: 12927862
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors.
    Sanchez-Martinez C; Shih C; Faul MM; Zhu G; Paal M; Somoza C; Li T; Kumrich CA; Winneroski LL; Xun Z; Brooks HB; Patel BK; Schultz RM; DeHahn TB; Spencer CD; Watkins SA; Considine E; Dempsey JA; Ogg CA; Campbell RM; Anderson BA; Wagner J
    Bioorg Med Chem Lett; 2003 Nov; 13(21):3835-9. PubMed ID: 14552791
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9.
    Shimamura T; Shibata J; Kurihara H; Mita T; Otsuki S; Sagara T; Hirai H; Iwasawa Y
    Bioorg Med Chem Lett; 2006 Jul; 16(14):3751-4. PubMed ID: 16682184
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Imidazo[1,2-a]pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation.
    Anderson M; Beattie JF; Breault GA; Breed J; Byth KF; Culshaw JD; Ellston RP; Green S; Minshull CA; Norman RA; Pauptit RA; Stanway J; Thomas AP; Jewsbury PJ
    Bioorg Med Chem Lett; 2003 Sep; 13(18):3021-6. PubMed ID: 12941325
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.