BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

250 related articles for article (PubMed ID: 10749682)

  • 21. Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.
    Wu MH; Lohrbach KE; Olopade OI; Kokkinakis DM; Friedman HS; Dolan ME
    Clin Cancer Res; 1999 Jan; 5(1):209-13. PubMed ID: 9918221
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling.
    Gronemeyer T; Chidley C; Juillerat A; Heinis C; Johnsson K
    Protein Eng Des Sel; 2006 Jul; 19(7):309-16. PubMed ID: 16638797
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine.
    Edara S; Kanugula S; Goodtzova K; Pegg AE
    Cancer Res; 1996 Dec; 56(24):5571-5. PubMed ID: 8971155
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Inactivation of O6-alkylguanine-DNA alkyltransferase by 8-substituted O6-benzylguanine analogs in mice.
    Ewesuedo RB; Wilson LR; Friedman HS; Moschel RC; Dolan ME
    Cancer Chemother Pharmacol; 2001; 47(1):63-9. PubMed ID: 11221964
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Davis BM; Reese JS; Koç ON; Lee K; Schupp JE; Gerson SL
    Cancer Res; 1997 Nov; 57(22):5093-9. PubMed ID: 9371508
    [TBL] [Abstract][Full Text] [Related]  

  • 26. O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU.
    Phillips WP; Willson JK; Markowitz SD; Zborowska E; Zaidi NH; Liu L; Gordon NH; Gerson SL
    Cancer Res; 1997 Nov; 57(21):4817-23. PubMed ID: 9354444
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide.
    Reese JS; Davis BM; Liu L; Gerson SL
    Clin Cancer Res; 1999 Jan; 5(1):163-9. PubMed ID: 9918215
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane.
    Liu L; Watanabe K; Fang Q; Williams KM; Guengerich FP; Pegg AE
    Chem Res Toxicol; 2007 Jan; 20(1):155-63. PubMed ID: 17226938
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Creation of human alkyltransferases resistant to O6-benzylguanine.
    Christians FC; Dawson BJ; Coates MM; Loeb LA
    Cancer Res; 1997 May; 57(10):2007-12. PubMed ID: 9157998
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA.
    Kooistra R; Zonneveld JB; Watson AJ; Margison GP; Lohman PH; Pastink A
    Nucleic Acids Res; 1999 Apr; 27(8):1795-801. PubMed ID: 10101186
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment.
    Maze R; Kurpad C; Pegg AE; Erickson LC; Williams DA
    J Pharmacol Exp Ther; 1999 Sep; 290(3):1467-74. PubMed ID: 10454526
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Depletion of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine in three-dimensional collagen cultures of normal human breast epithelial cells.
    Hamdan MA; Guzman RC; Yang J; Beattie C; Mascharack P; Nandi S
    Carcinogenesis; 1992 Oct; 13(10):1743-9. PubMed ID: 1423833
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Clinical relevance of MGMT in the treatment of cancer.
    Gerson SL
    J Clin Oncol; 2002 May; 20(9):2388-99. PubMed ID: 11981013
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine.
    Edara S; Kanugula S; Pegg AE
    Carcinogenesis; 1999 Jan; 20(1):103-8. PubMed ID: 9934856
    [TBL] [Abstract][Full Text] [Related]  

  • 35. DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.
    Koç ON; Reese JS; Davis BM; Liu L; Majczenko KJ; Gerson SL
    Hum Gene Ther; 1999 Apr; 10(6):1021-30. PubMed ID: 10223735
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase.
    Daniels DS; Tainer JA
    Mutat Res; 2000 Aug; 460(3-4):151-63. PubMed ID: 10946226
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically resectable tumors.
    Dolan ME; Posner M; Karrison T; Radosta J; Steinberg G; Bertucci D; Vujasin L; Ratain MJ
    Clin Cancer Res; 2002 Aug; 8(8):2519-23. PubMed ID: 12171878
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts.
    Lukash LL; Boldt J; Pegg AE; Dolan ME; Maher VM; McCormick JJ
    Mutat Res; 1991; 250(1-2):397-409. PubMed ID: 1944354
    [TBL] [Abstract][Full Text] [Related]  

  • 39. O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair.
    Spiro TP; Gerson SL; Liu L; Majka S; Haaga J; Hoppel CL; Ingalls ST; Pluda JM; Willson JK
    Cancer Res; 1999 May; 59(10):2402-10. PubMed ID: 10344750
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Engineering human DNA alkyltransferases for gene therapy using random sequence mutagenesis.
    Encell LP; Coates MM; Loeb LA
    Cancer Res; 1998 Mar; 58(5):1013-20. PubMed ID: 9500464
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.