129 related articles for article (PubMed ID: 10767777)
1. Isolation from pig liver microsomes, identification by tandem mass spectrometry and in vitro immunosuppressive activity of an SDZ-RAD 17,18,19,20,21,22-tris-epoxide.
Lhoëst GJ; Gougnard TY; Verbeeck RK; Maton N; Dehoux JP; Wallemacq P; Schüler W; Latinne D
J Mass Spectrom; 2000 Mar; 35(3):454-60. PubMed ID: 10767777
[TBL] [Abstract][Full Text] [Related]
2. Isolation from pig liver microsomes, identification by electrospray tandem mass spectrometry and in vitro immunosuppressive activity of a rapamycin tris-epoxide metabolite.
Lhoëst G; Zey T; Verbeeck RK; Wallemacq P; Maton N; De Houx JP; Latinne D
J Mass Spectrom; 1999 Jan; 34(1):28-32. PubMed ID: 10028689
[TBL] [Abstract][Full Text] [Related]
3. In vitro immunosuppressive activity of tacrolimus dihydrodiol precursors obtained by chemical oxidation and identification of a new metabolite of SDZ-RAD by electrospray and electrospray-linked scan mass spectrometry.
Lhoëst G; Hertsens R; Verbeeck RK; Maton N; Wallemacq P; Dehoux JP; Latinne D
J Mass Spectrom; 2001 Aug; 36(8):889-901. PubMed ID: 11523088
[TBL] [Abstract][Full Text] [Related]
4. In vitro immunosuppressive activity, isolation from pig liver microsomes and identification by electrospray ms-ms of a new FK-506 C19-C20 epoxide metabolite.
Lhoëst G; Dieden R; Verbeeck RK; Maton N; Ingendoh A; Latinne D
J Pharmacol Exp Ther; 1998 Mar; 284(3):1074-81. PubMed ID: 9495869
[TBL] [Abstract][Full Text] [Related]
5. Structural elucidation by electrospray mass spectrometry: an approach to the in vitro metabolism of the macrolide immunosuppressant SDZ RAD.
Vidal C; Kirchner GI; Sewing KF
J Am Soc Mass Spectrom; 1998 Dec; 9(12):1267-74. PubMed ID: 9835072
[TBL] [Abstract][Full Text] [Related]
6. Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine.
Serkova N; Hausen B; Berry GJ; Jacobsen W; Benet LZ; Morris RE; Christians U
J Pharmacol Exp Ther; 2000 Jul; 294(1):323-32. PubMed ID: 10871329
[TBL] [Abstract][Full Text] [Related]
7. Absorption and intestinal metabolism of SDZ-RAD and rapamycin in rats.
Crowe A; Bruelisauer A; Duerr L; Guntz P; Lemaire M
Drug Metab Dispos; 1999 May; 27(5):627-32. PubMed ID: 10220493
[TBL] [Abstract][Full Text] [Related]
8. Identification of a new metabolite of macrolide immunosuppressant, like rapamycin and SDZ RAD, using high performance liquid chromatography and electrospray tandem mass spectrometry.
Hallensleben K; Raida M; Habermehl G
J Am Soc Mass Spectrom; 2000 Jun; 11(6):516-25. PubMed ID: 10833025
[TBL] [Abstract][Full Text] [Related]
9. Evaluation for synergistic suppression of T cell responses to minor histocompatibility antigens by chloroquine in combination with tacrolimus and a rapamycin derivative, SDZ-RAD.
Hsiao CC; Su WN; Forooghian F; Bader S; Rempel J; HayGlass KT; Gilman A; Schultz KR
Bone Marrow Transplant; 2002 Dec; 30(12):905-13. PubMed ID: 12476284
[TBL] [Abstract][Full Text] [Related]
10. Isolation of two immunosuppressive metabolites after in vitro metabolism of rapamycin.
Christians U; Sattler M; Schiebel HM; Kruse C; Radeke HH; Linck A; Sewing KF
Drug Metab Dispos; 1992; 20(2):186-91. PubMed ID: 1352208
[TBL] [Abstract][Full Text] [Related]
11. Isolation, identification and immunosuppressive activity of a new IMM-125 metabolite from human liver microsomes. Identification of its cyclophilin A-IMM-125 metabolite complex by nanospray tandem mass spectrometry.
Lhoëst GJ; de Jong AP; Meiring HD; Maton N; Latinne D; Verbeeck RK; Otte JB; Zurini M
J Mass Spectrom; 1998 Oct; 33(10):936-42. PubMed ID: 9821326
[TBL] [Abstract][Full Text] [Related]
12. SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo.
Schuler W; Sedrani R; Cottens S; Häberlin B; Schulz M; Schuurman HJ; Zenke G; Zerwes HG; Schreier MH
Transplantation; 1997 Jul; 64(1):36-42. PubMed ID: 9233698
[TBL] [Abstract][Full Text] [Related]
13. Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin.
Segarra I; Brazelton TR; Guterman N; Hausen B; Jacobsen W; Morris RE; Benet LZ; Christians U
J Chromatogr B Biomed Sci Appl; 1998 Dec; 720(1-2):179-87. PubMed ID: 9892080
[TBL] [Abstract][Full Text] [Related]
14. The macrolide everolimus forms an unusual metabolite in animals and humans: identification of a phosphocholine ester.
Zollinger M; Sayer C; Dannecker R; Schuler W; Sedrani R
Drug Metab Dispos; 2008 Aug; 36(8):1457-60. PubMed ID: 18448571
[TBL] [Abstract][Full Text] [Related]
15. Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (rapamycin) by electrospray-MS/MS after incubation with human liver microsomes.
Streit F; Christians U; Schiebel HM; Meyer A; Sewing KF
Drug Metab Dispos; 1996 Nov; 24(11):1272-8. PubMed ID: 8937863
[TBL] [Abstract][Full Text] [Related]
16. Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus.
Boernsen KO; Egge-Jacobsen W; Inverardi B; Strom T; Streit F; Schiebel HM; Benet LZ; Christians U
J Mass Spectrom; 2007 Jun; 42(6):793-802. PubMed ID: 17511017
[TBL] [Abstract][Full Text] [Related]
17. Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506.
Iwasaki K; Shiraga T; Matsuda H; Nagase K; Tokuma Y; Hata T; Fujii Y; Sakuma S; Fujitsu T; Fujikawa A
Drug Metab Dispos; 1995 Jan; 23(1):28-34. PubMed ID: 7536652
[TBL] [Abstract][Full Text] [Related]
18. Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone.
Iwasaki K; Shiraga T; Nagase K; Tozuka Z; Noda K; Sakuma S; Fujitsu T; Shimatani K; Sato A; Fujioka M
Drug Metab Dispos; 1993; 21(6):971-7. PubMed ID: 7507815
[TBL] [Abstract][Full Text] [Related]
19. Isolation and identification of a C39 demethylated metabolite of rapamycin from pig liver microsomes and evaluation of its immunosuppressive activity.
Nickmilder MJ; Latinne D; De Houx JP; Verbeeck RK; Lhoëst GJ
Clin Chem; 1998 Mar; 44(3):532-8. PubMed ID: 9510858
[TBL] [Abstract][Full Text] [Related]
20. The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates.
Serkova N; Litt L; Leibfritz D; Hausen B; Morris RE; James TL; Benet LZ; Christians U
Br J Pharmacol; 2000 Feb; 129(3):485-92. PubMed ID: 10711346
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]