BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

249 related articles for article (PubMed ID: 10770929)

  • 1. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.
    Wellington CL; Singaraja R; Ellerby L; Savill J; Roy S; Leavitt B; Cattaneo E; Hackam A; Sharp A; Thornberry N; Nicholson DW; Bredesen DE; Hayden MR
    J Biol Chem; 2000 Jun; 275(26):19831-8. PubMed ID: 10770929
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
    Wellington CL; Ellerby LM; Gutekunst CA; Rogers D; Warby S; Graham RK; Loubser O; van Raamsdonk J; Singaraja R; Yang YZ; Gafni J; Bredesen D; Hersch SM; Leavitt BR; Roy S; Nicholson DW; Hayden MR
    J Neurosci; 2002 Sep; 22(18):7862-72. PubMed ID: 12223539
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.
    Gafni J; Hermel E; Young JE; Wellington CL; Hayden MR; Ellerby LM
    J Biol Chem; 2004 May; 279(19):20211-20. PubMed ID: 14981075
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.
    Luo S; Vacher C; Davies JE; Rubinsztein DC
    J Cell Biol; 2005 May; 169(4):647-56. PubMed ID: 15911879
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
    Hermel E; Gafni J; Propp SS; Leavitt BR; Wellington CL; Young JE; Hackam AS; Logvinova AV; Peel AL; Chen SF; Hook V; Singaraja R; Krajewski S; Goldsmith PC; Ellerby HM; Hayden MR; Bredesen DE; Ellerby LM
    Cell Death Differ; 2004 Apr; 11(4):424-38. PubMed ID: 14713958
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.
    Busch A; Engemann S; Lurz R; Okazawa H; Lehrach H; Wanker EE
    J Biol Chem; 2003 Oct; 278(42):41452-61. PubMed ID: 12888569
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.
    Graham RK; Deng Y; Carroll J; Vaid K; Cowan C; Pouladi MA; Metzler M; Bissada N; Wang L; Faull RL; Gray M; Yang XW; Raymond LA; Hayden MR
    J Neurosci; 2010 Nov; 30(45):15019-29. PubMed ID: 21068307
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
    Graham RK; Deng Y; Slow EJ; Haigh B; Bissada N; Lu G; Pearson J; Shehadeh J; Bertram L; Murphy Z; Warby SC; Doty CN; Roy S; Wellington CL; Leavitt BR; Raymond LA; Nicholson DW; Hayden MR
    Cell; 2006 Jun; 125(6):1179-91. PubMed ID: 16777606
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.
    Ellerby LM; Andrusiak RL; Wellington CL; Hackam AS; Propp SS; Wood JD; Sharp AH; Margolis RL; Ross CA; Salvesen GS; Hayden MR; Bredesen DE
    J Biol Chem; 1999 Mar; 274(13):8730-6. PubMed ID: 10085113
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.
    Kim YJ; Yi Y; Sapp E; Wang Y; Cuiffo B; Kegel KB; Qin ZH; Aronin N; DiFiglia M
    Proc Natl Acad Sci U S A; 2001 Oct; 98(22):12784-9. PubMed ID: 11675509
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Aggregation in Huntington's disease: insights through modelling.
    Cajavec B; Bernard S; Herzel H
    Genome Inform; 2005; 16(1):262-71. PubMed ID: 16362929
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.
    Miller JP; Holcomb J; Al-Ramahi I; de Haro M; Gafni J; Zhang N; Kim E; Sanhueza M; Torcassi C; Kwak S; Botas J; Hughes RE; Ellerby LM
    Neuron; 2010 Jul; 67(2):199-212. PubMed ID: 20670829
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity.
    Schilling B; Gafni J; Torcassi C; Cong X; Row RH; LaFevre-Bernt MA; Cusack MP; Ratovitski T; Hirschhorn R; Ross CA; Gibson BW; Ellerby LM
    J Biol Chem; 2006 Aug; 281(33):23686-97. PubMed ID: 16782707
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin.
    Jiang H; Poirier MA; Liang Y; Pei Z; Weiskittel CE; Smith WW; DeFranco DB; Ross CA
    Neurobiol Dis; 2006 Sep; 23(3):543-51. PubMed ID: 16766198
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
    Gervais FG; Singaraja R; Xanthoudakis S; Gutekunst CA; Leavitt BR; Metzler M; Hackam AS; Tam J; Vaillancourt JP; Houtzager V; Rasper DM; Roy S; Hayden MR; Nicholson DW
    Nat Cell Biol; 2002 Feb; 4(2):95-105. PubMed ID: 11788820
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Huntington disease: new insights on the role of huntingtin cleavage.
    Wellington CL; Leavitt BR; Hayden MR
    J Neural Transm Suppl; 2000; (58):1-17. PubMed ID: 11128600
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death.
    Conforti P; Camnasio S; Mutti C; Valenza M; Thompson M; Fossale E; Zeitlin S; MacDonald ME; Zuccato C; Cattaneo E
    Neurobiol Dis; 2013 Feb; 50():160-70. PubMed ID: 23089356
    [TBL] [Abstract][Full Text] [Related]  

  • 18. CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.
    Apostol BL; Simmons DA; Zuccato C; Illes K; Pallos J; Casale M; Conforti P; Ramos C; Roarke M; Kathuria S; Cattaneo E; Marsh JL; Thompson LM
    Mol Cell Neurosci; 2008 Sep; 39(1):8-20. PubMed ID: 18602275
    [TBL] [Abstract][Full Text] [Related]  

  • 19. cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues.
    Chiang MC; Lee YC; Huang CL; Chern Y
    J Biol Chem; 2005 Apr; 280(14):14331-40. PubMed ID: 15689617
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
    Waldron-Roby E; Ratovitski T; Wang X; Jiang M; Watkin E; Arbez N; Graham RK; Hayden MR; Hou Z; Mori S; Swing D; Pletnikov M; Duan W; Tessarollo L; Ross CA
    J Neurosci; 2012 Jan; 32(1):183-93. PubMed ID: 22219281
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.