These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

302 related articles for article (PubMed ID: 10785598)

  • 1. Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed.
    Peters GJ; van Triest B; Backus HH; Kuiper CM; van der Wilt CL; Pinedo HM
    Eur J Cancer; 2000 May; 36(7):916-24. PubMed ID: 10785598
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates.
    Backus HH; Pinedo HM; Wouters D; Kuiper CM; Jansen G; van Groeningen CJ; Peters GJ
    Oncol Res; 2000; 12(5):231-9. PubMed ID: 11417748
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines.
    Backus HH; Wouters D; Ferreira CG; van Houten VM; Brakenhoff RH; Pinedo HM; Peters GJ
    Eur J Cancer; 2003 Jun; 39(9):1310-7. PubMed ID: 12763222
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
    Peters GJ; Smitskamp-Wilms E; Smid K; Pinedo HM; Jansen G
    Cancer Res; 1999 Nov; 59(21):5529-35. PubMed ID: 10554030
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.
    Van Triest B; Pinedo HM; Giaccone G; Peters GJ
    Ann Oncol; 2000 Apr; 11(4):385-91. PubMed ID: 10847455
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.
    Giovannetti E; Backus HH; Wouters D; Ferreira CG; van Houten VM; Brakenhoff RH; Poupon MF; Azzarello A; Pinedo HM; Peters GJ
    Br J Cancer; 2007 Mar; 96(5):769-75. PubMed ID: 17339891
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction.
    Neuteboom ST; Karjian PL; Boyer CR; Beryt M; Pegram M; Wahl GM; Shepard HM
    Mol Cancer Ther; 2002 Apr; 1(6):377-84. PubMed ID: 12477050
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
    van Triest B; Pinedo HM; van Hensbergen Y; Smid K; Telleman F; Schoenmakers PS; van der Wilt CL; van Laar JA; Noordhuis P; Jansen G; Peters GJ
    Clin Cancer Res; 1999 Mar; 5(3):643-54. PubMed ID: 10100718
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines.
    van der Wilt CL; Kuiper CM; Peters GJ
    Oncol Res; 1999; 11(8):383-91. PubMed ID: 10803742
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates.
    Longley DB; Boyer J; Allen WL; Latif T; Ferguson PR; Maxwell PJ; McDermott U; Lynch M; Harkin DP; Johnston PG
    Cancer Res; 2002 May; 62(9):2644-9. PubMed ID: 11980662
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Schedule-dependent interaction between raltitrexed and 5-fluorouracil in human colon cancer cell lines in vitro.
    Kano Y; Akutsu M; Suzuki K; Yazawa Y; Tsunoda S; Furukawa Y
    Oncol Res; 2000; 12(3):137-48. PubMed ID: 11216672
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status.
    Mirjolet JF; Barberi-Heyob M; Didelot C; Peyrat JP; Abecassis J; Millon R; Merlin JL
    Br J Cancer; 2000 Nov; 83(10):1380-6. PubMed ID: 11044365
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status.
    Violette S; Poulain L; Dussaulx E; Pepin D; Faussat AM; Chambaz J; Lacorte JM; Staedel C; Lesuffleur T
    Int J Cancer; 2002 Apr; 98(4):498-504. PubMed ID: 11920608
    [TBL] [Abstract][Full Text] [Related]  

  • 14. DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells.
    Matsui SI; Arredondo MA; Wrzosek C; Rustum YM
    Cancer Res; 1996 Oct; 56(20):4715-23. PubMed ID: 8840989
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.
    Backus HH; Pinedo HM; Wouters D; PadrĂ³n JM; Molders N; van Der Wilt CL; van Groeningen CJ; Jansen G; Peters GJ
    Int J Cancer; 2000 Sep; 87(6):771-8. PubMed ID: 10956384
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins.
    Nita ME; Nagawa H; Tominaga O; Tsuno N; Fujii S; Sasaki S; Fu CG; Takenoue T; Tsuruo T; Muto T
    Br J Cancer; 1998 Oct; 78(8):986-92. PubMed ID: 9792140
    [TBL] [Abstract][Full Text] [Related]  

  • 17. p53 and WAF1 are induced and Rb protein is hypophosphorylated during cell growth inhibition by the thymidylate synthase inhibitor ZD1694 (Tomudex).
    Yin MB; Voigt W; Panadero A; Vanhoefer U; Frank C; Pajovic S; Azizkhan J; Rustum YM
    Mol Pharmacol; 1997 Apr; 51(4):630-6. PubMed ID: 9106628
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells.
    van der Wilt CL; Smid K; Aherne GW; Noordhuis P; Peters GJ
    Eur J Cancer; 1997 Mar; 33(3):471-8. PubMed ID: 9155534
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A rationale for the clinical development of the thymidylate synthase inhibitor ZD9331 in ovarian and other solid tumours.
    Jackman AL; Melin CJ; Kimbell R; Brunton L; Aherne GW; Theti DS; Walton M
    Biochim Biophys Acta; 2002 Jul; 1587(2-3):215-23. PubMed ID: 12084463
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks.
    Wang W; McLeod HL; Cassidy J; Collie-Duguid ES
    Cancer Chemother Pharmacol; 2007 May; 59(6):839-45. PubMed ID: 17119966
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.