BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

171 related articles for article (PubMed ID: 10800930)

  • 1. Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptide Abeta42 in late compartments of the constitutive secretory pathway.
    Petanceska SS; Seeger M; Checler F; Gandy S
    J Neurochem; 2000 May; 74(5):1878-84. PubMed ID: 10800930
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
    Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Presenilin-1 mutations associated with familial Alzheimer's disease do not disrupt protein transport from the endoplasmic reticulum to the Golgi apparatus.
    Tan Y; Hong J; Doan T; McConlogue L; Maltese WA
    Biochim Biophys Acta; 1998 Jul; 1407(1):69-78. PubMed ID: 9639678
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.
    Sudoh S; Kawamura Y; Sato S; Wang R; Saido TC; Oyama F; Sakaki Y; Komano H; Yanagisawa K
    J Neurochem; 1998 Oct; 71(4):1535-43. PubMed ID: 9751187
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.
    Gandy S; Zhang YW; Ikin A; Schmidt SD; Bogush A; Levy E; Sheffield R; Nixon RA; Liao FF; Mathews PM; Xu H; Ehrlich ME
    J Neurochem; 2007 Aug; 102(3):619-26. PubMed ID: 17630980
    [TBL] [Abstract][Full Text] [Related]  

  • 6. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
    Chen WT; Hsieh YF; Huang YJ; Lin CC; Lin YT; Liu YC; Lien CC; Cheng IH
    Mol Neurobiol; 2015 Dec; 52(3):1835-1849. PubMed ID: 25394380
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
    Chen F; Yang DS; Petanceska S; Yang A; Tandon A; Yu G; Rozmahel R; Ghiso J; Nishimura M; Zhang DM; Kawarai T; Levesque G; Mills J; Levesque L; Song YQ; Rogaeva E; Westaway D; Mount H; Gandy S; St George-Hyslop P; Fraser PE
    J Biol Chem; 2000 Nov; 275(47):36794-802. PubMed ID: 10962005
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2.
    Takeda K; Araki W; Tabira T
    Eur J Neurosci; 2004 Jan; 19(2):258-264. PubMed ID: 14725619
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.
    Murayama O; Tomita T; Nihonmatsu N; Murayama M; Sun X; Honda T; Iwatsubo T; Takashima A
    Neurosci Lett; 1999 Apr; 265(1):61-3. PubMed ID: 10327206
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation.
    Sudoh S; Hua G; Kawamura Y; Maruyama K; Komano H; Yanagisawa K
    Eur J Biochem; 2000 Apr; 267(7):2036-45. PubMed ID: 10727943
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.
    Iwata H; Tomita T; Maruyama K; Iwatsubo T
    J Biol Chem; 2001 Jun; 276(24):21678-85. PubMed ID: 11283011
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.
    Ancolio K; Marambaud P; Dauch P; Checler F
    J Neurochem; 1997 Dec; 69(6):2494-9. PubMed ID: 9375682
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons.
    Annaert WG; Levesque L; Craessaerts K; Dierinck I; Snellings G; Westaway D; George-Hyslop PS; Cordell B; Fraser P; De Strooper B
    J Cell Biol; 1999 Oct; 147(2):277-94. PubMed ID: 10525535
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
    Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mutant presenilin (A260V) affects Rab8 in PC12D cell.
    Kametani F; Usami M; Tanaka K; Kume H; Mori H
    Neurochem Int; 2004 Apr; 44(5):313-20. PubMed ID: 14643748
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.
    Tomita T; Tokuhiro S; Hashimoto T; Aiba K; Saido TC; Maruyama K; Iwatsubo T
    J Biol Chem; 1998 Aug; 273(33):21153-60. PubMed ID: 9694871
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
    Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.
    Refolo LM; Eckman C; Prada CM; Yager D; Sambamurti K; Mehta N; Hardy J; Younkin SG
    J Neurochem; 1999 Dec; 73(6):2383-8. PubMed ID: 10582597
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Implications of presenilin 1 mutations in Alzheimer's disease.
    Komano H; Sudoh S; Kawamura Y; Wang R; Yanagisawa K
    Mech Ageing Dev; 1999 Mar; 107(3):281-98. PubMed ID: 10360683
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.