BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

152 related articles for article (PubMed ID: 10806188)

  • 1. Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.
    Loo TW; Clarke DM
    J Biol Chem; 2000 Jun; 275(26):19435-8. PubMed ID: 10806188
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains.
    Loo TW; Bartlett MC; Clarke DM
    J Biol Chem; 2003 Jan; 278(3):1575-8. PubMed ID: 12421806
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence.
    Loo TW; Bartlett MC; Clarke DM
    J Biol Chem; 2002 Nov; 277(44):41303-6. PubMed ID: 12226074
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein.
    Urbatsch IL; Gimi K; Wilke-Mounts S; Lerner-Marmarosh N; Rousseau ME; Gros P; Senior AE
    J Biol Chem; 2001 Jul; 276(29):26980-7. PubMed ID: 11356825
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity.
    Loo TW; Clarke DM
    J Biol Chem; 1995 Sep; 270(39):22957-61. PubMed ID: 7559432
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane.
    Loo TW; Bartlett MC; Clarke DM
    J Biol Chem; 2004 Feb; 279(9):7692-7. PubMed ID: 14670948
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity.
    Loo TW; Clarke DM
    J Biol Chem; 2014 Sep; 289(36):24749-58. PubMed ID: 25053414
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of oxidative cross-linking between engineered cysteine residues at positions 332 in predicted transmembrane segments (TM) 6 and 975 in predicted TM12 of human P-glycoprotein by drug substrates.
    Loo TW; Clarke DM
    J Biol Chem; 1996 Nov; 271(44):27482-7. PubMed ID: 8910331
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein.
    Loo TW; Clarke DM
    J Biol Chem; 2014 Jan; 289(1):229-36. PubMed ID: 24275649
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together.
    Loo TW; Bartlett MC; Detty MR; Clarke DM
    J Biol Chem; 2012 Aug; 287(32):26806-16. PubMed ID: 22700974
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Processing mutations disrupt interactions between the nucleotide binding and transmembrane domains of P-glycoprotein and the cystic fibrosis transmembrane conductance regulator (CFTR).
    Loo TW; Bartlett MC; Clarke DM
    J Biol Chem; 2008 Oct; 283(42):28190-7. PubMed ID: 18708637
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.
    Loo TW; Clarke DM
    J Biol Chem; 2000 Feb; 275(8):5253-6. PubMed ID: 10681495
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Attachment of a 'molecular spring' restores drug-stimulated ATPase activity to P-glycoprotein lacking both Q loop glutamines.
    Loo TW; Clarke DM
    Biochem Biophys Res Commun; 2017 Jan; 483(1):366-370. PubMed ID: 28025146
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Nucleotide binding, ATP hydrolysis, and mutation of the catalytic carboxylates of human P-glycoprotein cause distinct conformational changes in the transmembrane segments.
    Loo TW; Bartlett MC; Clarke DM
    Biochemistry; 2007 Aug; 46(32):9328-36. PubMed ID: 17636884
    [TBL] [Abstract][Full Text] [Related]  

  • 15. ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transport.
    Yang R; Cui L; Hou YX; Riordan JR; Chang XB
    J Biol Chem; 2003 Aug; 278(33):30764-71. PubMed ID: 12783859
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1-NBD2 heterodimer.
    Stratford FL; Ramjeesingh M; Cheung JC; Huan LJ; Bear CE
    Biochem J; 2007 Jan; 401(2):581-6. PubMed ID: 16989640
    [TBL] [Abstract][Full Text] [Related]  

  • 17. P-glycoprotein retains drug-stimulated ATPase activity upon covalent linkage of the two nucleotide binding domains at their C-terminal ends.
    Verhalen B; Wilkens S
    J Biol Chem; 2011 Mar; 286(12):10476-82. PubMed ID: 21278250
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1.
    Gao M; Cui HR; Loe DW; Grant CE; Almquist KC; Cole SP; Deeley RG
    J Biol Chem; 2000 Apr; 275(17):13098-108. PubMed ID: 10777615
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Permanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site.
    Loo TW; Bartlett MC; Clarke DM
    J Biol Chem; 2003 Jun; 278(23):20449-52. PubMed ID: 12711602
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface.
    Loo TW; Bartlett MC; Clarke DM
    J Biol Chem; 2013 Jul; 288(28):20326-33. PubMed ID: 23733192
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.