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BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

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  • 1. Ask the doctor. I suffer from shortness of breath. My internist has sent me to a cardiologist, who said the cause is not my heart. Then I went to a lung specialist, who said it was not my lungs. I feel like no one wants to take responsibility for helping me!
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  • 2. I've been experiencing some shortness of breath while doing simple things around the house, like vacuuming or carrying the laundry upstairs. Tests of my lung function turned out normal. Now my doctor wants to check further for possible heart problems. Please explain how shortness of breath can be related to my heart.
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  • 5. Ask the doctor. While I was getting my teeth cleaned, the dental hygienists asked me about my heart condition. She seemed surprised when I told her I had a healthy heart, because she said I had creases on both my earlobes. Is this an urban legend, or is it something I should be worried about?
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  • 8. Ask the doctor. In October 2007, I had three Cypher stents placed in my left anterior descending artery. My doctor told me to take Plavix and aspirin indefinitely. Now I need to have a hernia repaired. My surgeon refuses to operate while I'm taking Plavix and aspirin, and said I would have to stop taking the two drugs five to six days before the operation. My cardiologist says that stopping the Plavix and aspirin, as well as the stress of the operation itself, would throw me into a "hypercoagulable state," greatly increasing my chance of developing a blood clot inside one of the stents. What should I do?
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  • 9. Ask the doctor. I try to exercise every day to raise my heart rate. The standard formula of 220 minus age (I'm 79) times 0.9 gives an excessively high target for me. Because my resting heart rate is under 50, I would need to more than double my heart rate to reach a target of 128. Does the standard formula apply to people like me?
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  • 10. [Differential diagnosis of dyspnea].
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  • 11. Ask the doctor. My total cholesterol level is well below 200. My LDL is low, my HDL high, and my triglycerides and homocysteine are both in the "desirable" range. The one thing out of whack is that my lipoprotein(a) level is more than double the "normal" limit. My cardiologist wants me to take niacin to bring it down. I can't find any information on how serious a problem this is, especially in the context of otherwise good cholesterol levels and a healthy lifestyle. (I exercise 5 days a week; eat a low-fat, high-fiber diet; and am not overweight.).
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  • 12. Ask the doctor. A few months ago, I was diagnosed with atrial fibrillation. My doctor put me on blood thinners for a few weeks and then performed electrical cardioversion. Naturally, I was asleep during the procedure, but I understand that they shocked me twice and both times my heart briefly returned to a normal rhythm. But after a few seconds it went back into atrial fibrillation. NOw my doctor has offered me a choice. I can stay in atrial fibrillation and take a blood thinner for the rest of my life. Or I can try a medication to restore a normal heart rhythm and give cardioversion another try (but I'll probably have to take the antiarrhythmia drug for a long time). Any suggestions?
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  • 13. Update: shortness of breath.
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  • 14. Dyspnea during pregnancy. Distinguishing cardiac from pulmonary causes.
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  • 15. I was experiencing shortness of breath and my doctor sent me to a cardiologist. He performed an echocardiogram. The diagnosis was "diastolic dysfunction." What's the significance.
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  • 16. Ask the doctor. I have had heart failure since my heart attack a year ago. My physician initially prescribed lisinopril, an angiotensin-converting enzyme (ACE) inhibitor. Unfortunately, I was one of the unlucky people who got a cough with this drug that was so annoying I had to stop taking it. Now my doctor wants me to try a newer drug called valsartan. Is it likely to help me?
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  • 17. Ask the doctor. I have diabetes, coronary artery disease, and heart failure. My doctor wants me to take a beta blocker, but I have heard that these drugs might be dangerous for people like me. Should I follow her advice?
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  • 18. [Lung, heart or psyche. What is the cause of dyspnea?].
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