BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

123 related articles for article (PubMed ID: 10820141)

  • 1. Comparison of imidazole- and 2-methyl imidazole-containing farnesyl-protein transferase inhibitors: interaction with and metabolism by rat hepatic cytochrome P450s.
    Tang C; Chiba M; Nishime J; Hochman JH; Chen I; Williams TM; Lin JH
    Drug Metab Dispos; 2000 Jun; 28(6):680-6. PubMed ID: 10820141
    [TBL] [Abstract][Full Text] [Related]  

  • 2. P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes.
    Chiba M; Tang C; Neway WE; Williams TM; Desolms SJ; Dinsmore CJ; Wai JS; Lin JH
    Biochem Pharmacol; 2001 Sep; 62(6):773-6. PubMed ID: 11551523
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue.
    Kuperman AV; Kalgutkar AS; Marfat A; Chambers RJ; Liston TE
    Drug Metab Dispos; 2001 Nov; 29(11):1403-9. PubMed ID: 11602515
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine.
    Teiber JF; Hollenberg PF
    Carcinogenesis; 2000 Aug; 21(8):1559-66. PubMed ID: 10910959
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacokinetics and metabolism of a RAS farnesyl transferase inhibitor in rats and dogs: in vitro-in vivo correlation.
    Singh R; Chen IW; Jin L; Silva MV; Arison BH; Lin JH; Wong BK
    Drug Metab Dispos; 2001 Dec; 29(12):1578-87. PubMed ID: 11717177
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.
    Niwa T; Shiraga T; Mitani Y; Terakawa M; Tokuma Y; Kagayama A
    Drug Metab Dispos; 2000 Sep; 28(9):1128-34. PubMed ID: 10950860
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Characterization of the cytochrome P450 enzymes and enzyme kinetic parameters for metabolism of BVT.2938 using different in vitro systems.
    Baranczewski P; Edlund PO; Postlind H
    J Pharm Biomed Anal; 2006 Mar; 40(5):1121-30. PubMed ID: 16307862
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes.
    Miyazawa M; Shindo M; Shimada T
    Drug Metab Dispos; 2001 Feb; 29(2):200-5. PubMed ID: 11159812
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies.
    Desta Z; Soukhova N; Mahal SK; Flockhart DA
    Drug Metab Dispos; 2000 Jul; 28(7):789-800. PubMed ID: 10859153
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Prediction of midazolam-CYP3A inhibitors interaction in the human liver from in vivo/in vitro absorption, distribution, and metabolism data.
    Yamano K; Yamamoto K; Katashima M; Kotaki H; Takedomi S; Matsuo H; Ohtani H; Sawada Y; Iga T
    Drug Metab Dispos; 2001 Apr; 29(4 Pt 1):443-52. PubMed ID: 11259329
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS; Hatch HL; Kosea F; Nguyen HT; Choo EF; McClure KF; Taylor TJ; Henne KR; Kuperman AV; Dombroski MA; Letavic MA
    Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity.
    Carlile DJ; Hakooz N; Houston JB
    Drug Metab Dispos; 1999 Apr; 27(4):526-32. PubMed ID: 10101148
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Preclinical metabolism of LB42908, a novel farnesyl transferase inhibitor, and its effects on the cytochrome P450 isozyme activities.
    Kim HJ; Lee SH; Koh JS; Lee SH
    Bioorg Med Chem Lett; 2012 May; 22(9):3067-71. PubMed ID: 22497764
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms.
    Shayeganpour A; El-Kadi AO; Brocks DR
    Drug Metab Dispos; 2006 Jan; 34(1):43-50. PubMed ID: 16204463
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists.
    Tang W; Stearns RA; Wang RW; Miller RR; Chen Q; Ngui J; Bakshi RK; Nargund RP; Dean DC; Baillie TA
    Xenobiotica; 2008 Nov; 38(11):1437-51. PubMed ID: 18841517
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes.
    Duhamel MC; Troncy E; Beaudry F
    Biomed Chromatogr; 2010 Aug; 24(8):868-77. PubMed ID: 20020418
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Current cytochrome P450 phenotyping methods applied to metabolic drug-drug interaction prediction in dogs.
    Mills BM; Zaya MJ; Walters RR; Feenstra KL; White JA; Gagne J; Locuson CW
    Drug Metab Dispos; 2010 Mar; 38(3):396-404. PubMed ID: 20007294
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Characterization of human cytochrome P450 enzymes involved in the in vitro metabolism of perospirone.
    Kitamura A; Mizuno Y; Natsui K; Yabuki M; Komuro S; Kanamaru H
    Biopharm Drug Dispos; 2005 Mar; 26(2):59-65. PubMed ID: 15619261
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam.
    Tang J; Amin Usmani K; Hodgson E; Rose RL
    Chem Biol Interact; 2004 Apr; 147(3):319-29. PubMed ID: 15135087
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Rate-limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir, and ritonavir.
    Parker AJ; Houston JB
    Drug Metab Dispos; 2008 Jul; 36(7):1375-84. PubMed ID: 18426953
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.