BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

454 related articles for article (PubMed ID: 10827174)

  • 1. The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage.
    Tortorella M; Pratta M; Liu RQ; Abbaszade I; Ross H; Burn T; Arner E
    J Biol Chem; 2000 Aug; 275(33):25791-7. PubMed ID: 10827174
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4).
    Tortorella MD; Pratta M; Liu RQ; Austin J; Ross OH; Abbaszade I; Burn T; Arner E
    J Biol Chem; 2000 Jun; 275(24):18566-73. PubMed ID: 10751421
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
    Tortorella MD; Burn TC; Pratta MA; Abbaszade I; Hollis JM; Liu R; Rosenfeld SA; Copeland RA; Decicco CP; Wynn R; Rockwell A; Yang F; Duke JL; Solomon K; George H; Bruckner R; Nagase H; Itoh Y; Ellis DM; Ross H; Wiswall BH; Murphy K; Hillman MC; Hollis GF; Newton RC; Magolda RL; Trzaskos JM; Arner EC
    Science; 1999 Jun; 284(5420):1664-6. PubMed ID: 10356395
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.
    Kashiwagi M; Enghild JJ; Gendron C; Hughes C; Caterson B; Itoh Y; Nagase H
    J Biol Chem; 2004 Mar; 279(11):10109-19. PubMed ID: 14662755
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1.
    Sandy JD; Thompson V; Doege K; Verscharen C
    Biochem J; 2000 Oct; 351(Pt 1):161-6. PubMed ID: 10998358
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2).
    Chockalingam PS; Zeng W; Morris EA; Flannery CR
    Arthritis Rheum; 2004 Sep; 50(9):2839-48. PubMed ID: 15457452
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions.
    Hörber C; Büttner FH; Kern C; Schmiedeknecht G; Bartnik E
    Matrix Biol; 2000 Nov; 19(6):533-43. PubMed ID: 11068207
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites.
    Tortorella MD; Pratta MA; Fox JW; Arner EC
    J Biol Chem; 1998 Mar; 273(10):5846-50. PubMed ID: 9488721
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
    Tortorella MD; Malfait AM; Deccico C; Arner E
    Osteoarthritis Cartilage; 2001 Aug; 9(6):539-52. PubMed ID: 11520168
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites.
    Flannery CR; Zeng W; Corcoran C; Collins-Racie LA; Chockalingam PS; Hebert T; Mackie SA; McDonagh T; Crawford TK; Tomkinson KN; LaVallie ER; Morris EA
    J Biol Chem; 2002 Nov; 277(45):42775-80. PubMed ID: 12202483
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.
    Tortorella MD; Arner EC; Hills R; Easton A; Korte-Sarfaty J; Fok K; Wittwer AJ; Liu RQ; Malfait AM
    J Biol Chem; 2004 Apr; 279(17):17554-61. PubMed ID: 14715656
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity.
    Fushimi K; Troeberg L; Nakamura H; Lim NH; Nagase H
    J Biol Chem; 2008 Mar; 283(11):6706-16. PubMed ID: 18156631
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The cleavage of biglycan by aggrecanases.
    Melching LI; Fisher WD; Lee ER; Mort JS; Roughley PJ
    Osteoarthritis Cartilage; 2006 Nov; 14(11):1147-54. PubMed ID: 16806997
    [TBL] [Abstract][Full Text] [Related]  

  • 14. TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4.
    Wayne GJ; Deng SJ; Amour A; Borman S; Matico R; Carter HL; Murphy G
    J Biol Chem; 2007 Jul; 282(29):20991-8. PubMed ID: 17470431
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo.
    Sandy JD; Verscharen C
    Biochem J; 2001 Sep; 358(Pt 3):615-26. PubMed ID: 11535123
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.
    Zeng W; Corcoran C; Collins-Racie LA; Lavallie ER; Morris EA; Flannery CR
    Biochim Biophys Acta; 2006 Mar; 1760(3):517-24. PubMed ID: 16507336
    [TBL] [Abstract][Full Text] [Related]  

  • 17. ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage.
    Collins-Racie LA; Flannery CR; Zeng W; Corcoran C; Annis-Freeman B; Agostino MJ; Arai M; DiBlasio-Smith E; Dorner AJ; Georgiadis KE; Jin M; Tan XY; Morris EA; LaVallie ER
    Matrix Biol; 2004 Jul; 23(4):219-30. PubMed ID: 15296936
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).
    Tortorella MD; Liu RQ; Burn T; Newton RC; Arner E
    Matrix Biol; 2002 Oct; 21(6):499-511. PubMed ID: 12392761
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase.
    Mercuri FA; Doege KJ; Arner EC; Pratta MA; Last K; Fosang AJ
    J Biol Chem; 1999 Nov; 274(45):32387-95. PubMed ID: 10542281
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.
    Malfait AM; Liu RQ; Ijiri K; Komiya S; Tortorella MD
    J Biol Chem; 2002 Jun; 277(25):22201-8. PubMed ID: 11956193
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.