These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
112 related articles for article (PubMed ID: 10827183)
1. Expression of human topoisomerase I with a partial deletion of the linker region yields monomeric and dimeric enzymes that respond differently to camptothecin. Ireton GC; Stewart L; Parker LH; Champoux JJ J Biol Chem; 2000 Aug; 275(33):25820-30. PubMed ID: 10827183 [TBL] [Abstract][Full Text] [Related]
2. A functional linker in human topoisomerase I is required for maximum sensitivity to camptothecin in a DNA relaxation assay. Stewart L; Ireton GC; Champoux JJ J Biol Chem; 1999 Nov; 274(46):32950-60. PubMed ID: 10551862 [TBL] [Abstract][Full Text] [Related]
3. DNA topoisomerase I domain interactions impact enzyme activity and sensitivity to camptothecin. Wright CM; van der Merwe M; DeBrot AH; Bjornsti MA J Biol Chem; 2015 May; 290(19):12068-78. PubMed ID: 25795777 [TBL] [Abstract][Full Text] [Related]
4. Biochemical and biophysical analyses of recombinant forms of human topoisomerase I. Stewart L; Ireton GC; Parker LH; Madden KR; Champoux JJ J Biol Chem; 1996 Mar; 271(13):7593-601. PubMed ID: 8631793 [TBL] [Abstract][Full Text] [Related]
5. Domains of human topoisomerase I and associated functions. Champoux JJ Prog Nucleic Acid Res Mol Biol; 1998; 60():111-32. PubMed ID: 9594573 [TBL] [Abstract][Full Text] [Related]
6. Reconstitution of human topoisomerase I by fragment complementation. Stewart L; Ireton GC; Champoux JJ J Mol Biol; 1997 Jun; 269(3):355-72. PubMed ID: 9199405 [TBL] [Abstract][Full Text] [Related]
7. Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin. van der Merwe M; Bjornsti MA J Biol Chem; 2008 Feb; 283(6):3305-3315. PubMed ID: 18056711 [TBL] [Abstract][Full Text] [Related]
8. Replacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistant. Arnò B; D'Annessa I; Tesauro C; Zuccaro L; Ottaviani A; Knudsen B; Fiorani P; Desideri A PLoS One; 2013; 8(7):e68404. PubMed ID: 23844196 [TBL] [Abstract][Full Text] [Related]
9. Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I. Fiorani P; Bruselles A; Falconi M; Chillemi G; Desideri A; Benedetti P J Biol Chem; 2003 Oct; 278(44):43268-75. PubMed ID: 12904303 [TBL] [Abstract][Full Text] [Related]
10. A pentapeptide signature motif plays a pivotal role in Leishmania DNA topoisomerase IB activity and camptothecin sensitivity. Prada CF; Alvarez-Velilla R; Diaz-González R; Prieto C; Pérez-Pertejo Y; Balaña-Fouce R; Reguera RM Biochim Biophys Acta; 2012 Dec; 1820(12):2062-71. PubMed ID: 23000572 [TBL] [Abstract][Full Text] [Related]
11. Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity. Fiorani P; Amatruda JF; Silvestri A; Butler RH; Bjornsti MA; Benedetti P Mol Pharmacol; 1999 Dec; 56(6):1105-15. PubMed ID: 10570037 [TBL] [Abstract][Full Text] [Related]
12. Mutational study of the "catalytic tetrad" of DNA topoisomerase IB from the hemoflagellate Leishmania donovani: Role of Asp-353 and Asn-221 in camptothecin resistance. Diaz-González R; Pérez-Pertejo Y; Pommier Y; Balaña-Fouce R; Reguera RM Biochem Pharmacol; 2008 Sep; 76(5):608-19. PubMed ID: 18655776 [TBL] [Abstract][Full Text] [Related]
13. Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate. Fertala J; Vance JR; Pourquier P; Pommier Y; Bjornsti MA J Biol Chem; 2000 May; 275(20):15246-53. PubMed ID: 10809761 [TBL] [Abstract][Full Text] [Related]
14. The domain organization of human topoisomerase I. Stewart L; Ireton GC; Champoux JJ J Biol Chem; 1996 Mar; 271(13):7602-8. PubMed ID: 8631794 [TBL] [Abstract][Full Text] [Related]
15. The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation. D'Annessa I; Tesauro C; Wang Z; Arnò B; Zuccaro L; Fiorani P; Desideri A Biochim Biophys Acta; 2013 Dec; 1834(12):2712-21. PubMed ID: 24096022 [TBL] [Abstract][Full Text] [Related]
16. Directed evolution to increase camptothecin sensitivity of human DNA topoisomerase I. Scaldaferro S; Tinelli S; Borgnetto ME; Azzini A; Capranico G Chem Biol; 2001 Sep; 8(9):871-81. PubMed ID: 11564555 [TBL] [Abstract][Full Text] [Related]
17. Identification of a minimal functional linker in human topoisomerase I by domain swapping with Cre recombinase. Frøhlich RF; Juul S; Nielsen MB; Vinther M; Veigaard C; Hede MS; Andersen FF Biochemistry; 2008 Jul; 47(27):7127-36. PubMed ID: 18553933 [TBL] [Abstract][Full Text] [Related]
18. Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal. Frøhlich RF; Veigaard C; Andersen FF; McClendon AK; Gentry AC; Andersen AH; Osheroff N; Stevnsner T; Knudsen BR Nucleic Acids Res; 2007; 35(18):6170-80. PubMed ID: 17827209 [TBL] [Abstract][Full Text] [Related]
19. Human DNA topoisomerase I: quantitative analysis of the effects of camptothecin analogs and the benzophenanthridine alkaloids nitidine and 6-ethoxydihydronitidine on DNA topoisomerase I-induced DNA strand breakage. Holden JA; Wall ME; Wani MC; Manikumar G Arch Biochem Biophys; 1999 Oct; 370(1):66-76. PubMed ID: 10496978 [TBL] [Abstract][Full Text] [Related]
20. Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants. Knab AM; Fertala J; Bjornsti MA J Biol Chem; 1993 Oct; 268(30):22322-30. PubMed ID: 8226741 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]