BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

160 related articles for article (PubMed ID: 10853669)

  • 21. Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
    Phillips GB; Buckman BO; Davey DD; Eagen KA; Guilford WJ; Hinchman J; Ho E; Koovakkat S; Liang A; Light DR; Mohan R; Ng HP; Post JM; Shaw KJ; Smith D; Subramanyam B; Sullivan ME; Trinh L; Vergona R; Walters J; White K; Whitlow M; Wu S; Xu W; Morrissey MM
    J Med Chem; 1998 Sep; 41(19):3557-62. PubMed ID: 9733480
    [No Abstract]   [Full Text] [Related]  

  • 22. Cinnamylindoline derivatives: synthesis and factor Xa (FXa) inhibitory activities.
    Noguchi T; Tanaka N; Nishimata T; Goto R; Hayakawa M; Sugidachi A; Ogawa T; Asai F; Fujimoto K
    Chem Pharm Bull (Tokyo); 2007 Oct; 55(10):1494-504. PubMed ID: 17917295
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Structural basis of the thrombin selectivity of a ligand that contains the constrained arginine mimic (2S)-2-amino-(3S)-3-(1-carbamimidoyl- piperidin-3-yl)-propanoic acid at P1.
    Narasimhan LS; Rubin JR; Holland DR; Plummer JS; Rapundalo ST; Edmunds JE; St-Denis Y; Siddiqui MA; Humblet C
    J Med Chem; 2000 Feb; 43(3):361-8. PubMed ID: 10669563
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Profiling the structural determinants for the selectivity of representative factor-Xa and thrombin inhibitors using combined ligand-based and structure-based approaches.
    Bhunia SS; Roy KK; Saxena AK
    J Chem Inf Model; 2011 Aug; 51(8):1966-85. PubMed ID: 21761917
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Indoline derivatives I: synthesis and factor Xa (FXa) inhibitory activities.
    Noguchi T; Tanaka N; Nishimata T; Goto R; Hayakawa M; Sugidachi A; Ogawa T; Asai F; Matsui Y; Fujimoto K
    Chem Pharm Bull (Tokyo); 2006 Feb; 54(2):163-74. PubMed ID: 16462058
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Design, synthesis, and structure-activity relationships of substituted piperazinone-based transition state factor Xa inhibitors.
    Su T; Yang H; Volkots D; Woolfrey J; Dam S; Wong P; Sinha U; Scarborough RM; Zhu BY
    Bioorg Med Chem Lett; 2003 Feb; 13(4):729-32. PubMed ID: 12639568
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Design, synthesis, and activity of a novel series of factor Xa inhibitors: optimization of arylamidine groups.
    Phillips G; Guilford WJ; Buckman BO; Davey DD; Eagen KA; Koovakkat S; Liang A; McCarrick M; Mohan R; Ng HP; Pinkerton M; Subramanyam B; Ho E; Trinh L; Whitlow M; Wu S; Xu W; Morrissey MM
    J Med Chem; 2002 Jun; 45(12):2484-93. PubMed ID: 12036356
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as a factor Xa inhibitor II. Substituent effect on biological activities.
    Nishida H; Miyazaki Y; Mukaihira T; Saitoh F; Fukui M; Harada K; Itoh M; Muraoka A; Matsusue T; Okamoto A; Hosaka Y; Matsumoto M; Ohnishi S; Mochizuki H
    Chem Pharm Bull (Tokyo); 2002 Sep; 50(9):1187-94. PubMed ID: 12237534
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Tetrahydro-isoquinoline-based factor Xa inhibitors.
    Kucznierz R; Grams F; Leinert H; Marzenell K; Engh RA; von der Saal W
    J Med Chem; 1998 Dec; 41(25):4983-94. PubMed ID: 9836616
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases.
    Tidwell RR; Geratz JD; Dann O; Volz G; Zeh D; Loewe H
    J Med Chem; 1978 Jul; 21(7):613-23. PubMed ID: 671460
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin.
    Stubbs MT; Huber R; Bode W
    FEBS Lett; 1995 Nov; 375(1-2):103-7. PubMed ID: 7498454
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa).
    Brink M; Dahlén A; Olsson T; Polla M; Svensson T
    Bioorg Med Chem; 2014 Apr; 22(7):2261-8. PubMed ID: 24588961
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Heterocyclic thrombin inhibitors. Part 1: design and synthesis of amidino-phenoxy quinoline derivatives.
    Ries UJ; Priepke HW; Hauel NH; Haaksma EE; Stassen JM; Wienen W; Nar H
    Bioorg Med Chem Lett; 2003 Jul; 13(14):2291-5. PubMed ID: 12824020
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa.
    Ewing WR; Becker MR; Manetta VE; Davis RS; Pauls HW; Mason H; Choi-Sledeski YM; Green D; Cha D; Spada AP; Cheney DL; Mason JS; Maignan S; Guilloteau JP; Brown K; Colussi D; Bentley R; Bostwick J; Kasiewski CJ; Morgan SR; Leadley RJ; Dunwiddie CT; Perrone MH; Chu V
    J Med Chem; 1999 Sep; 42(18):3557-71. PubMed ID: 10479288
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids.
    Sagi K; Nakagawa T; Yamanashi M; Makino S; Takahashi M; Takayanagi M; Takenaka K; Suzuki N; Oono S; Kataoka N; Ishikawa K; Shima S; Fukuda Y; Kayahara T; Takehana S; Shima Y; Tashiro K; Yamamoto H; Yoshimoto R; Iwata S; Tsuji T; Sakurai K; Shoji M
    J Med Chem; 2003 May; 46(10):1845-57. PubMed ID: 12723948
    [TBL] [Abstract][Full Text] [Related]  

  • 36. New substrate analogue inhibitors of factor Xa containing 4-amidinobenzylamide as P1 residue: part 1.
    Schweinitz A; Stürzebecher A; Stürzebecher U; Schuster O; Stürzebecher J; Steinmetzer T
    Med Chem; 2006 Jul; 2(4):349-61. PubMed ID: 16848746
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Diamidino-alpha,omega-diphenoxyalkanes. Structure-activity relationships for the inhibition of thrombin, pancreatic kallikrein, and trypsin.
    Geratz JD; Whitmore AC
    J Med Chem; 1973 Sep; 16(9):970-5. PubMed ID: 4795664
    [No Abstract]   [Full Text] [Related]  

  • 38. Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity.
    de Candia M; Fiorella F; Lopopolo G; Carotti A; Romano MR; Lograno MD; Martel S; Carrupt PA; Belviso BD; Caliandro R; Altomare C
    J Med Chem; 2013 Nov; 56(21):8696-711. PubMed ID: 24102612
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.
    Lin J; Deng H; Jin L; Pandey P; Quinn J; Cantin S; Rynkiewicz MJ; Gorga JC; Bibbins F; Celatka CA; Nagafuji P; Bannister TD; Meyers HV; Babine RE; Hayward NJ; Weaver D; Benjamin H; Stassen F; Abdel-Meguid SS; Strickler JE
    J Med Chem; 2006 Dec; 49(26):7781-91. PubMed ID: 17181160
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Nonbenzamidine tetrazole derivatives as factor Xa inhibitors.
    Quan ML; Ellis CD; He MY; Liauw AY; Woerner FJ; Alexander RS; Knabb RM; Lam PY; Luettgen JM; Wong PC; Wright MR; Wexler RR
    Bioorg Med Chem Lett; 2003 Feb; 13(3):369-73. PubMed ID: 12565931
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.