BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

196 related articles for article (PubMed ID: 10864207)

  • 1. Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent.
    Patterson LH; McKeown SR; Ruparelia K; Double JA; Bibby MC; Cole S; Stratford IJ
    Br J Cancer; 2000 Jun; 82(12):1984-90. PubMed ID: 10864207
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine.
    Friery OP; Gallagher R; Murray MM; Hughes CM; Galligan ES; McIntyre IA; Patterson LH; Hirst DG; McKeown SR
    Br J Cancer; 2000 Apr; 82(8):1469-73. PubMed ID: 10780528
    [TBL] [Abstract][Full Text] [Related]  

  • 3. AQ4N: a new approach to hypoxia-activated cancer chemotherapy.
    Patterson LH; McKeown SR
    Br J Cancer; 2000 Dec; 83(12):1589-93. PubMed ID: 11104551
    [TBL] [Abstract][Full Text] [Related]  

  • 4. DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells.
    Hejmadi MV; McKeown SR; Friery OP; McIntyre IA; Patterson LH; Hirst DG
    Br J Cancer; 1996 Feb; 73(4):499-505. PubMed ID: 8595165
    [TBL] [Abstract][Full Text] [Related]  

  • 5. AQ4N: an alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo.
    McKeown SR; Hejmadi MV; McIntyre IA; McAleer JJ; Patterson LH
    Br J Cancer; 1995 Jul; 72(1):76-81. PubMed ID: 7599069
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A cytochrome P450 2B6 meditated gene therapy strategy to enhance the effects of radiation or cyclophosphamide when combined with the bioreductive drug AQ4N.
    McErlane V; Yakkundi A; McCarthy HO; Hughes CM; Patterson LH; Hirst DG; Robson T; McKeown SR
    J Gene Med; 2005 Jul; 7(7):851-9. PubMed ID: 15712360
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Antitumour prodrug development using cytochrome P450 (CYP) mediated activation.
    Patterson LH; McKeown SR; Robson T; Gallagher R; Raleigh SM; Orr S
    Anticancer Drug Des; 1999 Dec; 14(6):473-86. PubMed ID: 10834269
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Evidence for a therapeutic gain when AQ4N or tirapazamine is combined with radiation.
    McKeown SR; Friery OP; McIntyre IA; Hejmadi MV; Patterson LH; Hirst DG
    Br J Cancer Suppl; 1996 Jul; 27():S39-42. PubMed ID: 8763843
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase I study.
    Albertella MR; Loadman PM; Jones PH; Phillips RM; Rampling R; Burnet N; Alcock C; Anthoney A; Vjaters E; Dunk CR; Harris PA; Wong A; Lalani AS; Twelves CJ
    Clin Cancer Res; 2008 Feb; 14(4):1096-104. PubMed ID: 18281542
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry.
    Atkinson SJ; Loadman PM; Sutton C; Patterson LH; Clench MR
    Rapid Commun Mass Spectrom; 2007; 21(7):1271-6. PubMed ID: 17340571
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts.
    Williams KJ; Albertella MR; Fitzpatrick B; Loadman PM; Shnyder SD; Chinje EC; Telfer BA; Dunk CR; Harris PA; Stratford IJ
    Mol Cancer Ther; 2009 Dec; 8(12):3266-75. PubMed ID: 19996276
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N.
    Gallagher R; Hughes CM; Murray MM; Friery OP; Patterson LH; Hirst DG; McKeown SR
    Br J Cancer; 2001 Aug; 85(4):625-9. PubMed ID: 11506506
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study.
    Steward WP; Middleton M; Benghiat A; Loadman PM; Hayward C; Waller S; Ford S; Halbert G; Patterson LH; Talbot D
    Ann Oncol; 2007 Jun; 18(6):1098-103. PubMed ID: 17442658
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The hypoxia-activated ProDrug AQ4N penetrates deeply in tumor tissues and complements the limited distribution of mitoxantrone.
    Trédan O; Garbens AB; Lalani AS; Tannock IF
    Cancer Res; 2009 Feb; 69(3):940-7. PubMed ID: 19176397
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N.
    McCarthy HO; Yakkundi A; McErlane V; Hughes CM; Keilty G; Murray M; Patterson LH; Hirst DG; McKeown SR; Robson T
    Cancer Gene Ther; 2003 Jan; 10(1):40-8. PubMed ID: 12489027
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Selective tumor targeting by the hypoxia-activated prodrug AQ4N blocks tumor growth and metastasis in preclinical models of pancreatic cancer.
    Lalani AS; Alters SE; Wong A; Albertella MR; Cleland JL; Henner WD
    Clin Cancer Res; 2007 Apr; 13(7):2216-25. PubMed ID: 17404106
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent.
    Patterson LH
    Cancer Metastasis Rev; 1993 Jun; 12(2):119-34. PubMed ID: 8375016
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Bioreductively activated antitumor N-oxides: the case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy.
    Patterson LH
    Drug Metab Rev; 2002 Aug; 34(3):581-92. PubMed ID: 12214668
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tumor-selective drug activation: a GDEPT approach utilizing cytochrome P450 1A1 and AQ4N.
    Yakkundi A; McErlane V; Murray M; McCarthy HO; Ward C; Hughes CM; Patterson LH; Hirst DG; McKeown SR; Robson T
    Cancer Gene Ther; 2006 Jun; 13(6):598-605. PubMed ID: 16410820
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A phase 1 open-label, accelerated dose-escalation study of the hypoxia-activated prodrug AQ4N in patients with advanced malignancies.
    Papadopoulos KP; Goel S; Beeram M; Wong A; Desai K; Haigentz M; Milián ML; Mani S; Tolcher A; Lalani AS; Sarantopoulos J
    Clin Cancer Res; 2008 Nov; 14(21):7110-5. PubMed ID: 18981010
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.