BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

283 related articles for article (PubMed ID: 10873110)

  • 1. Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
    Welsh SJ; Titley J; Brunton L; Valenti M; Monaghan P; Jackman AL; Aherne GW
    Clin Cancer Res; 2000 Jun; 6(6):2538-46. PubMed ID: 10873110
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
    van der Wilt CL; Backus HH; Smid K; Comijn L; Veerman G; Wouters D; Voorn DA; Priest DG; Bunni MA; Mitchell F; Jackman AL; Jansen G; Peters GJ
    Cancer Res; 2001 May; 61(9):3675-81. PubMed ID: 11325838
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs.
    Schultz RM; Chen VJ; Bewley JR; Roberts EF; Shih C; Dempsey JA
    Semin Oncol; 1999 Apr; 26(2 Suppl 6):68-73. PubMed ID: 10598558
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
    van Triest B; Pinedo HM; van Hensbergen Y; Smid K; Telleman F; Schoenmakers PS; van der Wilt CL; van Laar JA; Noordhuis P; Jansen G; Peters GJ
    Clin Cancer Res; 1999 Mar; 5(3):643-54. PubMed ID: 10100718
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
    Peters GJ; Smitskamp-Wilms E; Smid K; Pinedo HM; Jansen G
    Cancer Res; 1999 Nov; 59(21):5529-35. PubMed ID: 10554030
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514.
    Schultz RM; Patel VF; Worzalla JF; Shih C
    Anticancer Res; 1999; 19(1A):437-43. PubMed ID: 10226579
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks.
    Wang W; McLeod HL; Cassidy J; Collie-Duguid ES
    Cancer Chemother Pharmacol; 2007 May; 59(6):839-45. PubMed ID: 17119966
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.
    Jackman AL; Kimbell R; Aherne GW; Brunton L; Jansen G; Stephens TC; Smith MN; Wardleworth JM; Boyle FT
    Clin Cancer Res; 1997 Jun; 3(6):911-21. PubMed ID: 9815766
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors.
    Wang W; Marsh S; Cassidy J; McLeod HL
    Cancer Res; 2001 Jul; 61(14):5505-10. PubMed ID: 11454699
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines.
    van der Wilt CL; Kuiper CM; Peters GJ
    Oncol Res; 1999; 11(8):383-91. PubMed ID: 10803742
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates.
    Longley DB; Boyer J; Allen WL; Latif T; Ferguson PR; Maxwell PJ; McDermott U; Lynch M; Harkin DP; Johnston PG
    Cancer Res; 2002 May; 62(9):2644-9. PubMed ID: 11980662
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331.
    Webley SD; Hardcastle A; Ladner RD; Jackman AL; Aherne GW
    Br J Cancer; 2000 Sep; 83(6):792-9. PubMed ID: 10952785
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Thymidylate synthase as a target for growth inhibition in methotrexate-sensitive and -resistant human head and neck cancer and leukemia cell lines.
    McGuire JJ; Magee KJ; Russell CA; Canestrari JM
    Oncol Res; 1997; 9(3):139-47. PubMed ID: 9220499
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Combining small interfering RNAs targeting thymidylate synthase and thymidine kinase 1 or 2 sensitizes human tumor cells to 5-fluorodeoxyuridine and pemetrexed.
    Di Cresce C; Figueredo R; Ferguson PJ; Vincent MD; Koropatnick J
    J Pharmacol Exp Ther; 2011 Sep; 338(3):952-63. PubMed ID: 21673071
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cell death in response to antimetabolites directed at thymidylate synthase.
    Barbour KW; Berger FG
    Cancer Chemother Pharmacol; 2008 Feb; 61(2):189-201. PubMed ID: 17396263
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine.
    Correale P; Del Vecchio MT; Di Genova G; Savellini GG; La Placa M; Terrosi C; Vestri M; Urso R; Lemonnier F; Aquino A; Bonmassar E; Giorgi G; Francini G; Cusi MG
    J Natl Cancer Inst; 2005 Oct; 97(19):1437-45. PubMed ID: 16204693
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells.
    Mauritz R; Bekkenk MW; Rots MG; Pieters R; Mini E; van Zantwijk CH; Veerman AJ; Peters GJ; Jansen G
    Clin Cancer Res; 1998 Oct; 4(10):2399-410. PubMed ID: 9796971
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells.
    Temmink OH; Hoogeland MF; Fukushima M; Peters GJ
    Cancer Chemother Pharmacol; 2006 Jan; 57(2):171-9. PubMed ID: 16010590
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Thymidylate synthase inhibitors as anticancer agents: from bench to bedside.
    Chu E; Callender MA; Farrell MP; Schmitz JC
    Cancer Chemother Pharmacol; 2003 Jul; 52 Suppl 1():S80-9. PubMed ID: 12819937
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition.
    Webley SD; Welsh SJ; Jackman AL; Aherne GW
    Br J Cancer; 2001 Aug; 85(3):446-52. PubMed ID: 11487279
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.