142 related articles for article (PubMed ID: 10882369)
1. Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability.
Wang Z; Yang D; Mohanakrishnan AK; Fanwick PE; Nampoothiri P; Hamel E; Cushman M
J Med Chem; 2000 Jun; 43(12):2419-29. PubMed ID: 10882369
[TBL] [Abstract][Full Text] [Related]
2. The effect of exchanging various substituents at the 2-position of 2-methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization.
Cushman M; Mohanakrishnan AK; Hollingshead M; Hamel E
J Med Chem; 2002 Oct; 45(21):4748-54. PubMed ID: 12361402
[TBL] [Abstract][Full Text] [Related]
3. Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.
Cushman M; He HM; Katzenellenbogen JA; Lin CM; Hamel E
J Med Chem; 1995 Jun; 38(12):2041-9. PubMed ID: 7783135
[TBL] [Abstract][Full Text] [Related]
4. Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization.
Edsall AB; Mohanakrishnan AK; Yang D; Fanwick PE; Hamel E; Hanson AD; Agoston GE; Cushman M
J Med Chem; 2004 Oct; 47(21):5126-39. PubMed ID: 15456256
[TBL] [Abstract][Full Text] [Related]
5. A steroid derivative with paclitaxel-like effects on tubulin polymerization.
Verdier-Pinard P; Wang Z; Mohanakrishnan AK; Cushman M; Hamel E
Mol Pharmacol; 2000 Mar; 57(3):568-75. PubMed ID: 10692498
[TBL] [Abstract][Full Text] [Related]
6. Estradiol dimer inhibits tubulin polymerization and microtubule dynamics.
Jurášek M; Černohorská M; Řehulka J; Spiwok V; Sulimenko T; Dráberová E; Darmostuk M; Gurská S; Frydrych I; Buriánová R; Ruml T; Hajdúch M; Bartůněk P; Dráber P; Džubák P; Drašar PB; Sedlák D
J Steroid Biochem Mol Biol; 2018 Oct; 183():68-79. PubMed ID: 29803726
[TBL] [Abstract][Full Text] [Related]
7. Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate.
Jourdan F; Leese MP; Dohle W; Hamel E; Ferrandis E; Newman SP; Purohit A; Reed MJ; Potter BV
J Med Chem; 2010 Apr; 53(7):2942-51. PubMed ID: 20225862
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and structure-activity profiles of A-homoestranes, the estratropones.
Miller TA; Bulman AL; Thompson CD; Garst ME; Macdonald TL
J Med Chem; 1997 Nov; 40(23):3836-41. PubMed ID: 9371249
[TBL] [Abstract][Full Text] [Related]
9. Interaction of a fluorescent derivative of paclitaxel (Taxol) with microtubules and tubulin-colchicine.
Han Y; Chaudhary AG; Chordia MD; Sackett DL; Perez-Ramirez B; Kingston DG; Bane S
Biochemistry; 1996 Nov; 35(45):14173-83. PubMed ID: 8916903
[TBL] [Abstract][Full Text] [Related]
10. Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth.
Cushman M; He HM; Katzenellenbogen JA; Varma RK; Hamel E; Lin CM; Ram S; Sachdeva YP
J Med Chem; 1997 Jul; 40(15):2323-34. PubMed ID: 9240348
[TBL] [Abstract][Full Text] [Related]
11. Synthesis, cytotoxic effects and tubulin polymerization inhibition of 1,4-disubstituted 1,2,3-triazole analogs of 2-methoxyestradiol.
Solum EJ; Vik A; Hansen TV
Steroids; 2014 Sep; 87():46-53. PubMed ID: 24923521
[TBL] [Abstract][Full Text] [Related]
12. 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.
D'Amato RJ; Lin CM; Flynn E; Folkman J; Hamel E
Proc Natl Acad Sci U S A; 1994 Apr; 91(9):3964-8. PubMed ID: 8171020
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and SAR requirements of adamantane-colchicine conjugates with both microtubule depolymerizing and tubulin clustering activities.
Zefirova ON; Nurieva EV; Shishov DV; Baskin II; Fuchs F; Lemcke H; Schröder F; Weiss DG; Zefirov NS; Kuznetsov SA
Bioorg Med Chem; 2011 Sep; 19(18):5529-38. PubMed ID: 21873068
[TBL] [Abstract][Full Text] [Related]
14. Linkages in tubulin-colchicine functions: the role of the ring C (C') oxygens and ring B in the controls.
Pérez-Ramírez B; Gorbunoff MJ; Timasheff SN
Biochemistry; 1998 Feb; 37(6):1646-61. PubMed ID: 9484236
[TBL] [Abstract][Full Text] [Related]
15. Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins.
Jiménez C; Ellahioui Y; Álvarez R; Aramburu L; Riesco A; González M; Vicente A; Dahdouh A; Ibn Mansour A; Jiménez C; Martín D; Sarmiento RG; Medarde M; Caballero E; Peláez R
Eur J Med Chem; 2015 Jul; 100():210-22. PubMed ID: 26092446
[TBL] [Abstract][Full Text] [Related]
16. Novel B-ring modified allocolchicinoids of the NCME series: design, synthesis, antimicrotubule activity and cytotoxicity.
Bergemann S; Brecht R; Büttner F; Guénard D; Gust R; Seitz G; Stubbs MT; Thoret S
Bioorg Med Chem; 2003 Apr; 11(7):1269-81. PubMed ID: 12628654
[TBL] [Abstract][Full Text] [Related]
17. Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A.
Mu F; Hamel E; Lee DJ; Pryor DE; Cushman M
J Med Chem; 2003 Apr; 46(9):1670-82. PubMed ID: 12699385
[TBL] [Abstract][Full Text] [Related]
18. Novel p-carborane-containing multitarget anticancer agents inspired by the metabolism of 17β-estradiol.
Kaise A; Ohta K; Endo Y
Bioorg Med Chem; 2017 Dec; 25(24):6371-6378. PubMed ID: 29054710
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and investigation of conformationally restricted analogues of lavendustin A as cytotoxic inhibitors of tubulin polymerization.
Mu F; Lee DJ; Pryor DE; Hamel E; Cushman M
J Med Chem; 2002 Oct; 45(21):4774-85. PubMed ID: 12361405
[TBL] [Abstract][Full Text] [Related]
20. Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization.
Gastpar R; Goldbrunner M; Marko D; von Angerer E
J Med Chem; 1998 Dec; 41(25):4965-72. PubMed ID: 9836614
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
