These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

167 related articles for article (PubMed ID: 10893311)

  • 1. Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum.
    Yuthavong Y; Vilaivan T; Chareonsethakul N; Kamchonwongpaisan S; Sirawaraporn W; Quarrell R; Lowe G
    J Med Chem; 2000 Jul; 43(14):2738-44. PubMed ID: 10893311
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum.
    Vilaivan T; Saesaengseerung N; Jarprung D; Kamchonwongpaisan S; Sirawaraporn W; Yuthavong Y
    Bioorg Med Chem; 2003 Jan; 11(2):217-24. PubMed ID: 12470716
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil.
    Vanichtanankul J; Taweechai S; Uttamapinant C; Chitnumsub P; Vilaivan T; Yuthavong Y; Kamchonwongpaisan S
    Antimicrob Agents Chemother; 2012 Jul; 56(7):3928-35. PubMed ID: 22526319
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-activity relationship and comparative docking studies for cycloguanil analogs as PfDHFR-TS inhibitors.
    Sivaprakasam P; Tosso PN; Doerksen RJ
    J Chem Inf Model; 2009 Jul; 49(7):1787-96. PubMed ID: 19588935
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 3D-QSAR analysis of cycloguanil derivatives as inhibitors of A16V + S108T mutant Plasmodium falciparum dihydrofolate reductase enzyme.
    Adane L; Bharatam PV
    J Mol Graph Model; 2009 Nov; 28(4):357-67. PubMed ID: 19796975
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.
    Kamchonwongpaisan S; Quarrell R; Charoensetakul N; Ponsinet R; Vilaivan T; Vanichtanankul J; Tarnchompoo B; Sirawaraporn W; Lowe G; Yuthavong Y
    J Med Chem; 2004 Jan; 47(3):673-80. PubMed ID: 14736247
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular epidemiology of malaria in Yaounde, Cameroon. VI. Sequence variations in the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene and in vitro resistance to pyrimethamine and cycloguanil.
    Basco LK; Ringwald P
    Am J Trop Med Hyg; 2000 Feb; 62(2):271-6. PubMed ID: 10813484
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities.
    Kamchonwongpaisan S; Charoensetakul N; Srisuwannaket C; Taweechai S; Rattanajak R; Vanichtanankul J; Vitsupakorn D; Arwon U; Thongpanchang C; Tarnchompoo B; Vilaivan T; Yuthavong Y
    Eur J Med Chem; 2020 Jun; 195():112263. PubMed ID: 32294614
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Quantitative structure-activity relationships for cycloguanil analogs as PfDHFR inhibitors using mathematical molecular descriptors.
    Basak SC; Mills D
    SAR QSAR Environ Res; 2010 Apr; 21(3-4):215-29. PubMed ID: 20544548
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Plasmodium falciparum: mutation pattern in the dihydrofolate reductase-thymidylate synthase genes of Vietnamese isolates, a novel mutation, and coexistence of two clones in a Thai patient.
    Zindrou S; Nguyen PD; Nguyen DS; Sköld O; Swedberg G
    Exp Parasitol; 1996 Oct; 84(1):56-64. PubMed ID: 8888732
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase.
    Fidock DA; Nomura T; Wellems TE
    Mol Pharmacol; 1998 Dec; 54(6):1140-7. PubMed ID: 9855645
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Homology modeling of wild type and pyrimethamine/cycloguanil-cross resistant mutant type Plasmodium falciparum dihydrofolate reductase. A model for antimalarial chemotherapy resistance.
    Santos-Filho OA; de Alencastro RB; Figueroa-Villar JD
    Biophys Chem; 2001 Jul; 91(3):305-17. PubMed ID: 11551441
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites.
    Sardarian A; Douglas KT; Read M; Sims PF; Hyde JE; Chitnumsub P; Sirawaraporn R; Sirawaraporn W
    Org Biomol Chem; 2003 Mar; 1(6):960-4. PubMed ID: 12929634
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Short communication: Prevalence of mutations associated with resistance to atovaquone and to the antifolate effect of proguanil in Plasmodium falciparum isolates from northern Ghana.
    Muehlen M; Schreiber J; Ehrhardt S; Otchwemah R; Jelinek T; Bienzle U; Mockenhaupt FP
    Trop Med Int Health; 2004 Mar; 9(3):361-3. PubMed ID: 14996365
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Molecular modeling of wild-type and antifolate resistant mutant Plasmodium falciparum DHFR.
    Delfino RT; Santos-Filho OA; Figueroa-Villar JD
    Biophys Chem; 2002 Aug; 98(3):287-300. PubMed ID: 12128181
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In silico ADMET study, docking, synthesis and antimalarial evaluation of thiazole-1,3,5-triazine derivatives as Pf-DHFR inhibitor.
    Sahu S; Ghosh SK; Gahtori P; Pratap Singh U; Bhattacharyya DR; Bhat HR
    Pharmacol Rep; 2019 Oct; 71(5):762-767. PubMed ID: 31351317
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Antifolate drug resistance and point mutations in Plasmodium falciparum in Kenya.
    Khan B; Omar S; Kanyara JN; Warren-Perry M; Nyalwidhe J; Peterson DS; Wellems T; Kaniaru S; Gitonga J; Mulaa FJ; Koech DK
    Trans R Soc Trop Med Hyg; 1997; 91(4):456-60. PubMed ID: 9373654
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast.
    Cortese JF; Plowe CV
    Mol Biochem Parasitol; 1998 Aug; 94(2):205-14. PubMed ID: 9747971
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Malaria antifolate resistance with contrasting Plasmodium falciparum dihydrofolate reductase (DHFR) polymorphisms in humans and Anopheles mosquitoes.
    Mharakurwa S; Kumwenda T; Mkulama MA; Musapa M; Chishimba S; Shiff CJ; Sullivan DJ; Thuma PE; Liu K; Agre P
    Proc Natl Acad Sci U S A; 2011 Nov; 108(46):18796-801. PubMed ID: 22065788
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil.
    Fidock DA; Wellems TE
    Proc Natl Acad Sci U S A; 1997 Sep; 94(20):10931-6. PubMed ID: 9380737
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.