BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 10905745)

  • 1. Preclinical safety assessment: in vitro -- in vivo testing.
    Højelse F
    Pharmacol Toxicol; 2000; 86 Suppl 1():6-7. PubMed ID: 10905745
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Safety evaluation to support First-In-Man investigations II: toxicology studies.
    Baldrick P
    Regul Toxicol Pharmacol; 2008 Jul; 51(2):237-43. PubMed ID: 18501490
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The way forward in reproductive/developmental toxicity testing.
    Spielmann H
    Altern Lab Anim; 2009 Dec; 37(6):641-56. PubMed ID: 20105000
    [TBL] [Abstract][Full Text] [Related]  

  • 4. How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.
    Kirkland D; Pfuhler S; Tweats D; Aardema M; Corvi R; Darroudi F; Elhajouji A; Glatt H; Hastwell P; Hayashi M; Kasper P; Kirchner S; Lynch A; Marzin D; Maurici D; Meunier JR; Müller L; Nohynek G; Parry J; Parry E; Thybaud V; Tice R; van Benthem J; Vanparys P; White P
    Mutat Res; 2007 Mar; 628(1):31-55. PubMed ID: 17293159
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Determination of genetic toxicity and potential carcinogenicity in vitro--challenges post the Seventh Amendment to the European Cosmetics Directive.
    Tweats DJ; Scott AD; Westmoreland C; Carmichael PL
    Mutagenesis; 2007 Jan; 22(1):5-13. PubMed ID: 17142828
    [TBL] [Abstract][Full Text] [Related]  

  • 6. An FDA perspective on the nonclinical use of the X-Omics technologies and the safety of new drugs.
    Jacobs A
    Toxicol Lett; 2009 Apr; 186(1):32-5. PubMed ID: 18809476
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Proposed integrated decision-tree testing strategies for mutagenicity and carcinogenicity in relation to the EU REACH legislation.
    Combes R; Grindon C; Cronin MT; Roberts DW; Garrod J
    Altern Lab Anim; 2007 May; 35(2):267-87. PubMed ID: 17559315
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Preclinical safety of anecortave acetate.
    Heaton J; Kastner P; Hackett R
    Surv Ophthalmol; 2007 Jan; 52 Suppl 1():S35-40. PubMed ID: 17240255
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Genetic toxicity assessment: employing the best science for human safety evaluation part III: the comet assay as an alternative to in vitro clastogenicity tests for early drug candidate selection.
    Witte I; Plappert U; de Wall H; Hartmann A
    Toxicol Sci; 2007 May; 97(1):21-6. PubMed ID: 17204584
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Integrated decision-tree testing strategies for mutagenicity and carcinogenicity with respect to the requirements of the EU REACH legislation.
    Combes R; Grindon C; Cronin MT; Roberts DW; Garrod JF
    Altern Lab Anim; 2008 Oct; 36 Suppl 1():43-63. PubMed ID: 19025331
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Preclinical safety profile of alendronate.
    Peter C; Rodan GA
    Int J Clin Pract Suppl; 1999 Apr; 101():3-8. PubMed ID: 12669734
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.
    Müller L; Gocke E; Lavé T; Pfister T
    Toxicol Lett; 2009 Nov; 190(3):317-29. PubMed ID: 19443141
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.
    EFSA GMO Panel Working Group on Animal Feeding Trials
    Food Chem Toxicol; 2008 Mar; 46 Suppl 1():S2-70. PubMed ID: 18328408
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Notes to applicants for marketing authorizations on the pre-clinical biological safety testing of medicinal products derived from biotechnology (and comparable products derived from chemical synthesis). Committee for Proprietary Medicinal Products: Ad Hoc Working Party on Biotechnology/Pharmacy and Working Party on Safety of Medicines.
    J Biol Stand; 1989 Jul; 17(3):203-12. PubMed ID: 2677013
    [No Abstract]   [Full Text] [Related]  

  • 15. The use of human cell line reporter gene-based assays in chemical toxicity testing.
    Scrivens M; Bhogal N
    Toxicol In Vitro; 2007 Oct; 21(7):1233-40. PubMed ID: 17604594
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Rodent carcinogenicity and toxicity, in vitro mutagenicity, and their physical chemical determinants.
    Benigni R; Andreoli C
    Mutat Res; 1993 Oct; 297(3):281-92. PubMed ID: 7692274
    [TBL] [Abstract][Full Text] [Related]  

  • 17. How accurate is in vitro prediction of carcinogenicity?
    Walmsley RM; Billinton N
    Br J Pharmacol; 2011 Mar; 162(6):1250-8. PubMed ID: 21091657
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens II. Further analysis of mammalian cell results, relative predictivity and tumour profiles.
    Kirkland D; Aardema M; Müller L; Makoto H
    Mutat Res; 2006 Sep; 608(1):29-42. PubMed ID: 16769241
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Safety assessment of biopharmaceuticals: Japanese perspective on ICH S6 guideline maintenance.
    Nakazawa T; Kurokawa M; Kimura K; Wakata A; Hisada S; Inoue T; Sagami F; Heidel SM; Kawakami K; Shinoda K; Onodera H; Kumagai Y; Ohno Y; Kawamura N; Yamazaki T; Inoue T
    J Toxicol Sci; 2008 Aug; 33(3):277-82. PubMed ID: 18670158
    [TBL] [Abstract][Full Text] [Related]  

  • 20. First exposure in man: toxicological considerations.
    Spindler P; Sjöberg P; Knudsen LE
    Pharmacol Toxicol; 2000; 86 Suppl 1():8-12. PubMed ID: 10905746
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.