BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

420 related articles for article (PubMed ID: 10924409)

  • 1. Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis.
    Su LK; Barnes CJ; Yao W; Qi Y; Lynch PM; Steinbach G
    Am J Hum Genet; 2000 Sep; 67(3):582-90. PubMed ID: 10924409
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis.
    Groves C; Lamlum H; Crabtree M; Williamson J; Taylor C; Bass S; Cuthbert-Heavens D; Hodgson S; Phillips R; Tomlinson I
    Am J Pathol; 2002 Jun; 160(6):2055-61. PubMed ID: 12057910
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.
    Lamlum H; Ilyas M; Rowan A; Clark S; Johnson V; Bell J; Frayling I; Efstathiou J; Pack K; Payne S; Roylance R; Gorman P; Sheer D; Neale K; Phillips R; Talbot I; Bodmer W; Tomlinson I
    Nat Med; 1999 Sep; 5(9):1071-5. PubMed ID: 10470088
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli.
    Bläker H; Sutter C; Kadmon M; Otto HF; Von Knebel-Doeberitz M; Gebert J; Helmke BM
    Genes Chromosomes Cancer; 2004 Oct; 41(2):93-8. PubMed ID: 15287021
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Different familial adenomatous polyposis phenotypes resulting from deletions of the entire APC exon 15.
    Su LK; Kohlmann W; Ward PA; Lynch PM
    Hum Genet; 2002 Jul; 111(1):88-95. PubMed ID: 12136240
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Germline mutations are frequent in the APC gene but absent in the beta-catenin gene in familial adenomatous polyposis patients.
    Cao X; Eu KW; Seow-Choen F; Cheah PY
    Genes Chromosomes Cancer; 1999 Aug; 25(4):396-8. PubMed ID: 10398435
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Transcript dosage effect in familial adenomatous polyposis: model offered by two kindreds with exon 9 APC gene mutations.
    Curia MC; Esposito DL; Aceto G; Palmirotta R; Crognale S; Valanzano R; Ficari F; Tonelli F; Battista P; Mariani-Costantini R; Cama A
    Hum Mutat; 1998; 11(3):197-201. PubMed ID: 9521420
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel germline APC mutations in Swedish patients with familial adenomatous polyposis and Gardner syndrome.
    Nilbert M; Fernebro J; Kristoffersson U
    Scand J Gastroenterol; 2000 Nov; 35(11):1200-3. PubMed ID: 11145293
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.
    Albuquerque C; Breukel C; van der Luijt R; Fidalgo P; Lage P; Slors FJ; Leitão CN; Fodde R; Smits R
    Hum Mol Genet; 2002 Jun; 11(13):1549-60. PubMed ID: 12045208
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.
    Sieber OM; Segditsas S; Knudsen AL; Zhang J; Luz J; Rowan AJ; Spain SL; Thirlwell C; Howarth KM; Jaeger EE; Robinson J; Volikos E; Silver A; Kelly G; Aretz S; Frayling I; Hutter P; Dunlop M; Guenther T; Neale K; Phillips R; Heinimann K; Tomlinson IP
    Gut; 2006 Oct; 55(10):1440-8. PubMed ID: 16461775
    [TBL] [Abstract][Full Text] [Related]  

  • 11. APC germline mutations identified in Czech patients with familial adenomatous polyposis.
    Kohoutová M; Stekrová J; Jirásek V; Kapras J
    Hum Mutat; 2002 Apr; 19(4):460-1. PubMed ID: 11933206
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.
    Crabtree M; Sieber OM; Lipton L; Hodgson SV; Lamlum H; Thomas HJ; Neale K; Phillips RK; Heinimann K; Tomlinson IP
    Oncogene; 2003 Jul; 22(27):4257-65. PubMed ID: 12833148
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ovarian steroid cell tumor with biallelic adenomatous polyposis coli inactivation in a patient with familial adenomatous polyposis.
    Hu PJ; Knoepp SM; Wu R; Cho KR
    Genes Chromosomes Cancer; 2012 Mar; 51(3):283-9. PubMed ID: 22120905
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A new germline stop codon mutation in exon 15 of the APC gene predisposing to familial adenomatous polyposis.
    Schirosi L; Pellegrino M; Tarantino P; Mauro S; Tinelli A; Greco M
    Int J Biol Markers; 2013 Dec; 28(4):e405-8. PubMed ID: 23873622
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Can APC mutation analysis contribute to therapeutic decisions in familial adenomatous polyposis? Experience from 680 FAP families.
    Friedl W; Caspari R; Sengteller M; Uhlhaas S; Lamberti C; Jungck M; Kadmon M; Wolf M; Fahnenstich J; Gebert J; Möslein G; Mangold E; Propping P
    Gut; 2001 Apr; 48(4):515-21. PubMed ID: 11247896
    [TBL] [Abstract][Full Text] [Related]  

  • 16. APC haploinsufficiency, but not CTNNB1 or CDH1 gene mutations, accounts for a fraction of familial adenomatous polyposis patients without APC truncating mutations.
    Venesio T; Balsamo A; Rondo-Spaudo M; Varesco L; Risio M; Ranzani GN
    Lab Invest; 2003 Dec; 83(12):1859-66. PubMed ID: 14691304
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Germline APC mutation on the beta-catenin binding site is associated with a decreased apoptotic level in colorectal adenomas.
    Venesio T; Balsamo A; Scordamaglia A; Bertolaso M; Arrigoni A; Sprujevnik T; Rossini FP; Risio M
    Mod Pathol; 2003 Jan; 16(1):57-65. PubMed ID: 12527714
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Contribution of APC and MUTYH mutations to familial adenomatous polyposis susceptibility in Hungary.
    Papp J; Kovacs ME; Matrai Z; Orosz E; Kásler M; Børresen-Dale AL; Olah E
    Fam Cancer; 2016 Jan; 15(1):85-97. PubMed ID: 26446593
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor.
    Couture J; Mitri A; Lagace R; Smits R; Berk T; Bouchard HL; Fodde R; Alman B; Bapat B
    Clin Genet; 2000 Mar; 57(3):205-12. PubMed ID: 10782927
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells.
    Yedid N; Kalma Y; Malcov M; Amit A; Kariv R; Caspi M; Rosin-Arbesfeld R; Ben-Yosef D
    BMC Cancer; 2016 Dec; 16(1):952. PubMed ID: 28010732
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.