These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine. Malherbe P; Kratochwil N; Zenner MT; Piussi J; Diener C; Kratzeisen C; Fischer C; Porter RH Mol Pharmacol; 2003 Oct; 64(4):823-32. PubMed ID: 14500738 [TBL] [Abstract][Full Text] [Related]
4. Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors. Yu M; Tueckmantel W; Wang X; Zhu A; Kozikowski AP; Brownell AL Nucl Med Biol; 2005 Aug; 32(6):631-40. PubMed ID: 16026710 [TBL] [Abstract][Full Text] [Related]
6. N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. Chen Y; Goudet C; Pin JP; Conn PJ Mol Pharmacol; 2008 Mar; 73(3):909-18. PubMed ID: 18056795 [TBL] [Abstract][Full Text] [Related]
7. Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices. Fazal A; Parker F; Palmer AM; Croucher MJ J Neurochem; 2003 Sep; 86(6):1346-58. PubMed ID: 12950444 [TBL] [Abstract][Full Text] [Related]
8. [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization. Anderson JJ; Rao SP; Rowe B; Giracello DR; Holtz G; Chapman DF; Tehrani L; Bradbury MJ; Cosford ND; Varney MA J Pharmacol Exp Ther; 2002 Dec; 303(3):1044-51. PubMed ID: 12438526 [TBL] [Abstract][Full Text] [Related]
9. Molecular mechanisms of group I metabotropic glutamate receptor mediated LTP and LTD in basolateral amygdala in vitro. Chen A; Hu WW; Jiang XL; Potegal M; Li H Psychopharmacology (Berl); 2017 Feb; 234(4):681-694. PubMed ID: 28028604 [TBL] [Abstract][Full Text] [Related]
10. Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP. Malherbe P; Kratochwil N; Mühlemann A; Zenner MT; Fischer C; Stahl M; Gerber PR; Jaeschke G; Porter RH J Neurochem; 2006 Jul; 98(2):601-15. PubMed ID: 16805850 [TBL] [Abstract][Full Text] [Related]
11. Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Battaglia G; Busceti CL; Molinaro G; Biagioni F; Storto M; Fornai F; Nicoletti F; Bruno V J Neurosci; 2004 Jan; 24(4):828-35. PubMed ID: 14749427 [TBL] [Abstract][Full Text] [Related]
12. Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester. Ott D; Floersheim P; Inderbitzin W; Stoehr N; Francotte E; Lecis G; Richert P; Rihs G; Flor PJ; Kuhn R; Gasparini F J Med Chem; 2000 Nov; 43(23):4428-36. PubMed ID: 11087567 [TBL] [Abstract][Full Text] [Related]
13. The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles. Varty GB; Grilli M; Forlani A; Fredduzzi S; Grzelak ME; Guthrie DH; Hodgson RA; Lu SX; Nicolussi E; Pond AJ; Parker EM; Hunter JC; Higgins GA; Reggiani A; Bertorelli R Psychopharmacology (Berl); 2005 Apr; 179(1):207-17. PubMed ID: 15682298 [TBL] [Abstract][Full Text] [Related]
14. A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators. Rodriguez AL; Nong Y; Sekaran NK; Alagille D; Tamagnan GD; Conn PJ Mol Pharmacol; 2005 Dec; 68(6):1793-802. PubMed ID: 16155210 [TBL] [Abstract][Full Text] [Related]
15. Ketamine, but not propofol, anaesthesia is regulated by metabotropic glutamate 5 receptors. Sou JH; Chan MH; Chen HH Br J Anaesth; 2006 May; 96(5):597-601. PubMed ID: 16531447 [TBL] [Abstract][Full Text] [Related]
16. Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors. Lea PM; Movsesyan VA; Faden AI Br J Pharmacol; 2005 Jun; 145(4):527-34. PubMed ID: 15821750 [TBL] [Abstract][Full Text] [Related]
17. Endogenous activation of group-I metabotropic glutamate receptors is required for differentiation and survival of cerebellar Purkinje cells. Catania MV; Bellomo M; Di Giorgi-Gerevini V; Seminara G; Giuffrida R; Romeo R; De Blasi A; Nicoletti F J Neurosci; 2001 Oct; 21(19):7664-73. PubMed ID: 11567056 [TBL] [Abstract][Full Text] [Related]
18. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Chen Y; Nong Y; Goudet C; Hemstapat K; de Paulis T; Pin JP; Conn PJ Mol Pharmacol; 2007 May; 71(5):1389-98. PubMed ID: 17303702 [TBL] [Abstract][Full Text] [Related]
19. Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1. Kohara A; Toya T; Tamura S; Watabiki T; Nagakura Y; Shitaka Y; Hayashibe S; Kawabata S; Okada M J Pharmacol Exp Ther; 2005 Oct; 315(1):163-9. PubMed ID: 15976016 [TBL] [Abstract][Full Text] [Related]
20. Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia. Guo W; Wei F; Zou S; Robbins MT; Sugiyo S; Ikeda T; Tu JC; Worley PF; Dubner R; Ren K J Neurosci; 2004 Oct; 24(41):9161-73. PubMed ID: 15483135 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]