114 related articles for article (PubMed ID: 10937709)
1. Phenylacetamides as selective alpha-1A adrenergic receptor antagonists.
Patane MA; DiPardo RM; Newton RC; Price RP; Broten TP; Chang RS; Ransom RW; Di Salvo J; Nagarathnam D; Forray C; Gluchowski C; Bock MG
Bioorg Med Chem Lett; 2000 Aug; 10(15):1621-4. PubMed ID: 10937709
[TBL] [Abstract][Full Text] [Related]
2. Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series.
Wong WC; Sun W; Lagu B; Tian D; Marzabadi MR; Zhang F; Nagarathnam D; Miao SW; Wetzel JM; Peng J; Forray C; Chang RS; Chen TB; Ransom R; O'Malley S; Broten TP; Kling P; Vyas KP; Zhang K; Gluchowski C
J Med Chem; 1999 Nov; 42(23):4804-13. PubMed ID: 10579843
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and structure-activity relationships of phthalimide-phenylpiperazines: a novel series of potent and selective alpha(1)(a)-adrenergic receptor antagonists.
Kuo GH; Prouty C; Murray WV; Pulito V; Jolliffe L; Cheung P; Varga S; Evangelisto M; Wang J
J Med Chem; 2000 Jun; 43(11):2183-95. PubMed ID: 10841797
[TBL] [Abstract][Full Text] [Related]
4. Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety.
Murali Dhar TG; Nagarathnam D; Marzabadi MR; Lagu B; Wong WC; Chiu G; Tyagarajan S; Miao SW; Zhang F; Sun W; Tian D; Shen Q; Zhang J; Wetzel JM; Forray C; Chang RS; Broten TP; Schorn TW; Chen TB; O'Malley S; Ransom R; Schneck K; Bendesky R; Harrell CM; Vyas KP
J Med Chem; 1999 Nov; 42(23):4778-93. PubMed ID: 10579841
[TBL] [Abstract][Full Text] [Related]
5. Design and synthesis of N-alkylated saccharins as selective alpha-1a adrenergic receptor antagonists.
Nerenberg JB; Erb JM; Thompson WJ; Lee HY; Guare JP; Munson PM; Bergman JM; Huff JR; Broten TP; Chang RS; Chen TB; O'Malley S; Schorn TW; Scott AL
Bioorg Med Chem Lett; 1998 Sep; 8(18):2467-72. PubMed ID: 9873563
[TBL] [Abstract][Full Text] [Related]
6. Selective alpha1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones.
Nantermet PG; Barrow JC; Selnick HG; Homnick CF; Freidinger RM; Chang RS; O'Malley SS; Reiss DR; Broten TP; Ransom RW; Pettibone DJ; Olah T; Forray C
Bioorg Med Chem Lett; 2000 Aug; 10(15):1625-8. PubMed ID: 10937710
[TBL] [Abstract][Full Text] [Related]
7. Selective alpha-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity.
Patane MA; DiPardo RM; Price RP; Chang RS; Ransom RW; O'Malley SS; Di Salvo J; Bock MG
Bioorg Med Chem Lett; 1998 Sep; 8(18):2495-500. PubMed ID: 9873568
[TBL] [Abstract][Full Text] [Related]
8. Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones.
Nagarathnam D; Miao SW; Lagu B; Chiu G; Fang J; Murali Dhar TG; Zhang J; Tyagarajan S; Marzabadi MR; Zhang F; Wong WC; Sun W; Tian D; Wetzel JM; Forray C; Chang RS; Broten TP; Ransom RW; Schorn TW; Chen TB; O'Malley S; Kling P; Schneck K; Bendesky R; Harrell CM
J Med Chem; 1999 Nov; 42(23):4764-77. PubMed ID: 10579840
[TBL] [Abstract][Full Text] [Related]
9. In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia.
Barrow JC; Nantermet PG; Selnick HG; Glass KL; Rittle KE; Gilbert KF; Steele TG; Homnick CF; Freidinger RM; Ransom RW; Kling P; Reiss D; Broten TP; Schorn TW; Chang RS; O'Malley SS; Olah TV; Ellis JD; Barrish A; Kassahun K; Leppert P; Nagarathnam D; Forray C
J Med Chem; 2000 Jul; 43(14):2703-18. PubMed ID: 10893308
[TBL] [Abstract][Full Text] [Related]
10. Pharmacophore development for antagonists at alpha 1 adrenergic receptor subtypes.
Bremner JB; Coban B; Griffith R
J Comput Aided Mol Des; 1996 Dec; 10(6):545-57. PubMed ID: 9007688
[TBL] [Abstract][Full Text] [Related]
11. Novel heterocycles as selective alpha1-adrenergic receptor antagonists.
Li X; McCoy KA; Murray WV; Jolliffe L; Pulito V
Bioorg Med Chem Lett; 2000 Oct; 10(20):2375-7. PubMed ID: 11055359
[TBL] [Abstract][Full Text] [Related]
12. Synthesis, pharmacology and pharmacokinetics of 3-(4-aryl-piperazin-1-ylalkyl)-uracils as uroselective alpha1A-antagonists.
Lopez FJ; Arias L; Chan R; Clarke DE; Elworthy TR; Ford AP; Guzman A; Jaime-Figueroa S; Jasper JR; Morgans DJ; Padilla F; Perez-Medrano A; Quintero C; Romero M; Sandoval L; Smith SA; Williams TJ; Blue DR
Bioorg Med Chem Lett; 2003 Jun; 13(11):1873-8. PubMed ID: 12749888
[TBL] [Abstract][Full Text] [Related]
13. Self-organizing molecular field analysis on alpha(1a)-adrenoceptor dihydropyridine antagonists.
Li M; Du L; Wu B; Xia L
Bioorg Med Chem; 2003 Sep; 11(18):3945-51. PubMed ID: 12927855
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.
Balle T; Perregaard J; Ramirez MT; Larsen AK; Søby KK; Liljefors T; Andersen K
J Med Chem; 2003 Jan; 46(2):265-83. PubMed ID: 12519065
[TBL] [Abstract][Full Text] [Related]
15. Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles.
Goble SD; Wang L; Howell KL; Bansal A; Berger R; Brockunier L; DiSalvo J; Feighner S; Harper B; He J; Hurley A; Hreniuk D; Parmee E; Robbins M; Salituro G; Sanfiz A; Streckfuss E; Watkins E; Weber AE; Struthers M; Edmondson SD
Bioorg Med Chem Lett; 2010 Mar; 20(6):1895-9. PubMed ID: 20181479
[TBL] [Abstract][Full Text] [Related]
16. Synthesis of benzodioxinopyrroles as selective alpha 2-adrenoceptor antagonists.
Kitchin J; Borthwick AD; Brodie AC; Cherry PC; Crame AJ; Pipe AJ; Procopiou PA; Seaman MA; Turnbull JP
Bioorg Med Chem; 1995 Dec; 3(12):1595-603. PubMed ID: 8770384
[TBL] [Abstract][Full Text] [Related]
17. Modeling of relationships between pharmacokinetics and blockade of agonist-induced elevation of intraurethral pressure and mean arterial pressure in conscious dogs treated with alpha(1)-adrenoceptor antagonists.
Witte DG; Brune ME; Katwala SP; Milicic I; Stolarik D; Hui YH; Marsh KC; Kerwin JF; Meyer MD; Hancock AA
J Pharmacol Exp Ther; 2002 Feb; 300(2):495-504. PubMed ID: 11805209
[TBL] [Abstract][Full Text] [Related]
18. 1,3-Dioxolane-based ligands as rigid analogues of naftopidil: structure-affinity/activity relationships at alpha1 and 5-HT1A receptors.
Sorbi C; Franchini S; Tait A; Prandi A; Gallesi R; Angeli P; Marucci G; Pirona L; Poggesi E; Brasili L
ChemMedChem; 2009 Mar; 4(3):393-9. PubMed ID: 19152363
[TBL] [Abstract][Full Text] [Related]
19. Structure-affinity studies for a novel series of homochiral naphtho and tetrahydronaphtho analogues of alpha 1 antagonist WB-4101.
Bolchi C; Catalano P; Fumagalli L; Gobbi M; Pallavicini M; Pedretti A; Villa L; Vistoli G; Valoti E
Bioorg Med Chem; 2004 Sep; 12(18):4937-51. PubMed ID: 15336273
[TBL] [Abstract][Full Text] [Related]
20. Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains.
Lagu B; Tian D; Nagarathnam D; Marzabadi MR; Wong WC; Miao SW; Zhang F; Sun W; Chiu G; Fang J; Forray C; Chang RS; Ransom RW; Chen TB; O'Malley S; Zhang K; Vyas KP; Gluchowski C
J Med Chem; 1999 Nov; 42(23):4794-803. PubMed ID: 10579842
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]