BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

479 related articles for article (PubMed ID: 10942430)

  • 1. Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity.
    Jana NR; Tanaka M; Wang Gh; Nukina N
    Hum Mol Genet; 2000 Aug; 9(13):2009-18. PubMed ID: 10942430
    [TBL] [Abstract][Full Text] [Related]  

  • 2. BAG-1 associates with the polyglutamine-expanded huntingtin aggregates.
    Jana NR; Nukina N
    Neurosci Lett; 2005 Apr; 378(3):171-5. PubMed ID: 15781153
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release.
    Jana NR; Zemskov EA; Wang Gh ; Nukina N
    Hum Mol Genet; 2001 May; 10(10):1049-59. PubMed ID: 11331615
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease.
    Wyttenbach A; Carmichael J; Swartz J; Furlong RA; Narain Y; Rankin J; Rubinsztein DC
    Proc Natl Acad Sci U S A; 2000 Mar; 97(6):2898-903. PubMed ID: 10717003
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation.
    Zhou H; Li SH; Li XJ
    J Biol Chem; 2001 Dec; 276(51):48417-24. PubMed ID: 11606565
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins.
    Mitsui K; Nakayama H; Akagi T; Nekooki M; Ohtawa K; Takio K; Hashikawa T; Nukina N
    J Neurosci; 2002 Nov; 22(21):9267-77. PubMed ID: 12417652
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.
    Cummings CJ; Mancini MA; Antalffy B; DeFranco DB; Orr HT; Zoghbi HY
    Nat Genet; 1998 Jun; 19(2):148-54. PubMed ID: 9620770
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.
    Goswami A; Dikshit P; Mishra A; Mulherkar S; Nukina N; Jana NR
    Biochem Biophys Res Commun; 2006 Mar; 342(1):184-90. PubMed ID: 16472774
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hsp70 and Hsp40 chaperones do not modulate retinal phenotype in SCA7 mice.
    Helmlinger D; Bonnet J; Mandel JL; Trottier Y; Devys D
    J Biol Chem; 2004 Dec; 279(53):55969-77. PubMed ID: 15494410
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease.
    Wyttenbach A; Swartz J; Kita H; Thykjaer T; Carmichael J; Bradley J; Brown R; Maxwell M; Schapira A; Orntoft TF; Kato K; Rubinsztein DC
    Hum Mol Genet; 2001 Aug; 10(17):1829-45. PubMed ID: 11532992
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease.
    Chai Y; Koppenhafer SL; Bonini NM; Paulson HL
    J Neurosci; 1999 Dec; 19(23):10338-47. PubMed ID: 10575031
    [TBL] [Abstract][Full Text] [Related]  

  • 12. RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells.
    Doi H; Okamura K; Bauer PO; Furukawa Y; Shimizu H; Kurosawa M; Machida Y; Miyazaki H; Mitsui K; Kuroiwa Y; Nukina N
    J Biol Chem; 2008 Mar; 283(10):6489-500. PubMed ID: 18167354
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hsp105alpha suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity.
    Ishihara K; Yamagishi N; Saito Y; Adachi H; Kobayashi Y; Sobue G; Ohtsuka K; Hatayama T
    J Biol Chem; 2003 Jul; 278(27):25143-50. PubMed ID: 12714591
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Tissue transglutaminase selectively modifies proteins associated with truncated mutant huntingtin in intact cells.
    Chun W; Lesort M; Tucholski J; Faber PW; MacDonald ME; Ross CA; Johnson GV
    Neurobiol Dis; 2001 Jun; 8(3):391-404. PubMed ID: 11442349
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70.
    Ormsby AR; Ramdzan YM; Mok YF; Jovanoski KD; Hatters DM
    J Biol Chem; 2013 Dec; 288(52):37192-203. PubMed ID: 24196953
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Suppression of protein aggregation by chaperone modification of high molecular weight complexes.
    Labbadia J; Novoselov SS; Bett JS; Weiss A; Paganetti P; Bates GP; Cheetham ME
    Brain; 2012 Apr; 135(Pt 4):1180-96. PubMed ID: 22396390
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury.
    Giffard RG; Xu L; Zhao H; Carrico W; Ouyang Y; Qiao Y; Sapolsky R; Steinberg G; Hu B; Yenari MA
    J Exp Biol; 2004 Aug; 207(Pt 18):3213-20. PubMed ID: 15299042
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins.
    Huang CC; Faber PW; Persichetti F; Mittal V; Vonsattel JP; MacDonald ME; Gusella JF
    Somat Cell Mol Genet; 1998 Jul; 24(4):217-33. PubMed ID: 10410676
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.
    Sang TK; Li C; Liu W; Rodriguez A; Abrams JM; Zipursky SL; Jackson GR
    Hum Mol Genet; 2005 Feb; 14(3):357-72. PubMed ID: 15590702
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular aspects of Huntington's disease.
    Walling HW; Baldassare JJ; Westfall TC
    J Neurosci Res; 1998 Nov; 54(3):301-8. PubMed ID: 9819135
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 24.