These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
349 related articles for article (PubMed ID: 10950851)
1. Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation. Obach RS Drug Metab Dispos; 2000 Sep; 28(9):1069-76. PubMed ID: 10950851 [TBL] [Abstract][Full Text] [Related]
2. Cytochrome P450-catalyzed metabolism of ezlopitant alkene (CJ-12,458), a pharmacologically active metabolite of ezlopitant: enzyme kinetics and mechanism of an alkene hydration reaction. Obach RS Drug Metab Dispos; 2001 Jul; 29(7):1057-67. PubMed ID: 11408374 [TBL] [Abstract][Full Text] [Related]
3. Pharmacokinetics of ezlopitant, a novel non-peptidic neurokinin-1 receptor antagonist in preclinical species and metabolite kinetics of the pharmacologically active metabolites. Reed-Hagen AE; Tsuchiya M; Shimada K; Wentland JA; Obach RS Biopharm Drug Dispos; 1999 Dec; 20(9):429-39. PubMed ID: 10951432 [TBL] [Abstract][Full Text] [Related]
4. Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine. Beulz-Riché D; Grudé P; Puozzo C; Sautel F; Filaquier C; Riché C; Ratanasavanh D Fundam Clin Pharmacol; 2005 Oct; 19(5):545-53. PubMed ID: 16176333 [TBL] [Abstract][Full Text] [Related]
5. Mechanism of cytochrome P4503A4- and 2D6-catalyzed dehydrogenation of ezlopitant as probed with isotope effects using five deuterated analogs. Obach RS Drug Metab Dispos; 2001 Dec; 29(12):1599-607. PubMed ID: 11717179 [TBL] [Abstract][Full Text] [Related]
6. Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes. Di Marco A; Yao D; Laufer R Eur J Biochem; 2003 Sep; 270(18):3768-77. PubMed ID: 12950260 [TBL] [Abstract][Full Text] [Related]
7. Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4. Spracklin DK; Thummel KE; Kharasch ED Drug Metab Dispos; 1996 Sep; 24(9):976-83. PubMed ID: 8886607 [TBL] [Abstract][Full Text] [Related]
8. The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsomes is catalyzed by CYP3A. Manchee GR; Eddershaw PJ; Ranshaw LE; Herriott D; Park GR; Bayliss MK; Tarbit MH Drug Metab Dispos; 1996 May; 24(5):555-9. PubMed ID: 8723736 [TBL] [Abstract][Full Text] [Related]
9. Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543. Khojasteh-Bakht SC; Rossulek MI; Fouda HG; Prakash C Xenobiotica; 2003 Dec; 33(12):1201-10. PubMed ID: 14742142 [TBL] [Abstract][Full Text] [Related]
10. Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data. Walker DK; Alabaster CT; Congrave GS; Hargreaves MB; Hyland R; Jones BC; Reed LJ; Smith DA Drug Metab Dispos; 1996 Apr; 24(4):447-55. PubMed ID: 8801060 [TBL] [Abstract][Full Text] [Related]
11. Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide. Zhang L; Fitzloff JF; Engel LC; Cook CS Xenobiotica; 2001 Feb; 31(2):73-83. PubMed ID: 11407536 [TBL] [Abstract][Full Text] [Related]
12. Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450. Zhao XJ; Yokoyama H; Chiba K; Wanwimolruk S; Ishizaki T J Pharmacol Exp Ther; 1996 Dec; 279(3):1327-34. PubMed ID: 8968357 [TBL] [Abstract][Full Text] [Related]
13. Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes. Bourrié M; Meunier V; Berger Y; Fabre G J Pharmacol Exp Ther; 1996 Apr; 277(1):321-32. PubMed ID: 8613937 [TBL] [Abstract][Full Text] [Related]
14. Characterization of metabolites of a NK1 receptor antagonist, CJ-11,972, in human liver microsomes and recombinant human CYP isoforms by liquid chromatography/tandem mass spectrometry. Prakash C; Lin J; Colizza K; Miao Z Rapid Commun Mass Spectrom; 2007; 21(17):2822-32. PubMed ID: 17661339 [TBL] [Abstract][Full Text] [Related]
15. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes. Patten CJ; Smith TJ; Murphy SE; Wang MH; Lee J; Tynes RE; Koch P; Yang CS Arch Biochem Biophys; 1996 Sep; 333(1):127-38. PubMed ID: 8806763 [TBL] [Abstract][Full Text] [Related]
16. Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6: implications for relating in vitro inhibition data to in vivo drug interactions. Margolis JM; Obach RS Drug Metab Dispos; 2003 May; 31(5):606-11. PubMed ID: 12695349 [TBL] [Abstract][Full Text] [Related]
17. Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol. Obach RS Drug Metab Dispos; 1997 Dec; 25(12):1359-69. PubMed ID: 9394025 [TBL] [Abstract][Full Text] [Related]
18. (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Margolis JM; O'Donnell JP; Mankowski DC; Ekins S; Obach RS Drug Metab Dispos; 2000 Oct; 28(10):1187-91. PubMed ID: 10997938 [TBL] [Abstract][Full Text] [Related]
19. Metabolism and effect of para-toluene-sulfonamide on rat liver microsomal cytochrome P450 from in vivo and in vitro studies. Zhou JQ; Tang ZQ; Zhang JN; Tang JC Acta Pharmacol Sin; 2006 May; 27(5):635-40. PubMed ID: 16626521 [TBL] [Abstract][Full Text] [Related]
20. Biosynthesis of an aminopiperidino metabolite of irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecine] by human hepatic microsomes. Haaz MC; Riché C; Rivory LP; Robert J Drug Metab Dispos; 1998 Aug; 26(8):769-74. PubMed ID: 9698291 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]