129 related articles for article (PubMed ID: 10969972)
1. CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound.
Forbes IT; Cooper DG; Dodds EK; Hickey DM; Ife RJ; Meeson M; Stockley M; Berkhout TA; Gohil J; Groot PH; Moores K
Bioorg Med Chem Lett; 2000 Aug; 10(16):1803-6. PubMed ID: 10969972
[TBL] [Abstract][Full Text] [Related]
2. Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists.
Pasternak A; Marino D; Vicario PP; Ayala JM; Cascierri MA; Parsons W; Mills SG; Maccoss M; Yang L
J Med Chem; 2006 Aug; 49(16):4801-4. PubMed ID: 16884289
[TBL] [Abstract][Full Text] [Related]
3. Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.
Witherington J; Bordas V; Cooper DG; Forbes IT; Gribble AD; Ife RJ; Berkhout T; Gohil J; Groot PH
Bioorg Med Chem Lett; 2001 Aug; 11(16):2177-80. PubMed ID: 11514164
[TBL] [Abstract][Full Text] [Related]
4. Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists.
Yang L; Butora G; Jiao RX; Pasternak A; Zhou C; Parsons WH; Mills SG; Vicario PP; Ayala JM; Cascieri MA; MacCoss M
J Med Chem; 2007 May; 50(11):2609-11. PubMed ID: 17461566
[TBL] [Abstract][Full Text] [Related]
5. Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives.
Moree WJ; Kataoka K; Ramirez-Weinhouse MM; Shiota T; Imai M; Sudo M; Tsutsumi T; Endo N; Muroga Y; Hada T; Tanaka H; Morita T; Greene J; Barnum D; Saunders J; Kato Y; Myers PL; Tarby CM
Bioorg Med Chem Lett; 2004 Nov; 14(21):5413-6. PubMed ID: 15454236
[TBL] [Abstract][Full Text] [Related]
6. CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach.
Berkhout TA; Blaney FE; Bridges AM; Cooper DG; Forbes IT; Gribble AD; Groot PH; Hardy A; Ife RJ; Kaur R; Moores KE; Shillito H; Willetts J; Witherington J
J Med Chem; 2003 Sep; 46(19):4070-86. PubMed ID: 12954060
[TBL] [Abstract][Full Text] [Related]
7. CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.
Wacker DA; Santella JB; Gardner DS; Varnes JG; Estrella M; DeLucca GV; Ko SS; Tanabe K; Watson PS; Welch PK; Covington M; Stowell NC; Wadman EA; Davies P; Solomon KA; Newton RC; Trainor GL; Friedman SM; Decicco CP; Duncia JV
Bioorg Med Chem Lett; 2002 Jul; 12(13):1785-9. PubMed ID: 12067561
[TBL] [Abstract][Full Text] [Related]
8. The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists.
Ting PC; Lee JF; Wu J; Umland SP; Aslanian R; Cao J; Dong Y; Garlisi CG; Gilbert EJ; Huang Y; Jakway J; Kelly J; Liu Z; McCombie S; Shah H; Tian F; Wan Y; Shih NY
Bioorg Med Chem Lett; 2005 Mar; 15(5):1375-8. PubMed ID: 15713390
[TBL] [Abstract][Full Text] [Related]
9. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series.
Moree WJ; Kataoka K; Ramirez-Weinhouse MM; Shiota T; Imai M; Tsutsumi T; Sudo M; Endo N; Muroga Y; Hada T; Fanning D; Saunders J; Kato Y; Myers PL; Tarby CM
Bioorg Med Chem Lett; 2008 Mar; 18(6):1869-73. PubMed ID: 18313297
[TBL] [Abstract][Full Text] [Related]
10. Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists.
Yang L; Zhou C; Guo L; Morriello G; Butora G; Pasternak A; Parsons WH; Mills SG; MacCoss M; Vicario PP; Zweerink H; Ayala JM; Goyal S; Hanlon WA; Cascieri MA; Springer MS
Bioorg Med Chem Lett; 2006 Jul; 16(14):3735-9. PubMed ID: 16698264
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and structure-activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists.
Xia M; Hou C; DeMong D; Pollack S; Pan M; Singer M; Matheis M; Murray W; Cavender D; Wachter M
Bioorg Med Chem Lett; 2008 Dec; 18(24):6468-70. PubMed ID: 18990568
[TBL] [Abstract][Full Text] [Related]
12. N-Benzylindole-2-carboxylic acids: potent functional antagonists of the CCR2b chemokine receptor.
Kettle JG; Faull AW; Barker AJ; Davies DH; Stone MA
Bioorg Med Chem Lett; 2004 Jan; 14(2):405-8. PubMed ID: 14698169
[TBL] [Abstract][Full Text] [Related]
13. Alpha-aminothiazole-gamma-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists.
Zhou C; Guo L; Parsons WH; Mills SG; MacCoss M; Vicario PP; Zweerink H; Cascieri MA; Springer MS; Yang L
Bioorg Med Chem Lett; 2007 Jan; 17(2):309-14. PubMed ID: 17092717
[TBL] [Abstract][Full Text] [Related]
14. The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: antagonists versus agonists.
Ting PC; Umland SP; Aslanian R; Cao J; Garlisi CG; Huang Y; Jakway J; Liu Z; Shah H; Tian F; Wan Y; Shih NY
Bioorg Med Chem Lett; 2005 Jun; 15(12):3020-3. PubMed ID: 15908209
[TBL] [Abstract][Full Text] [Related]
15. Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists.
De Lucca GV; Kim UT; Johnson C; Vargo BJ; Welch PK; Covington M; Davies P; Solomon KA; Newton RC; Trainor GL; Decicco CP; Ko SS
J Med Chem; 2002 Aug; 45(17):3794-804. PubMed ID: 12166951
[TBL] [Abstract][Full Text] [Related]
16. Evidence for negative binding cooperativity within CCR5-CCR2b heterodimers.
El-Asmar L; Springael JY; Ballet S; Andrieu EU; Vassart G; Parmentier M
Mol Pharmacol; 2005 Feb; 67(2):460-9. PubMed ID: 15509716
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, and discovery of a novel CCR1 antagonist.
Naya A; Sagara Y; Ohwaki K; Saeki T; Ichikawa D; Iwasawa Y; Noguchi K; Ohtake N
J Med Chem; 2001 Apr; 44(9):1429-35. PubMed ID: 11311066
[TBL] [Abstract][Full Text] [Related]
18. Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas.
Burrows JN; Cumming JG; Fillery SM; Hamlin GA; Hudson JA; Jackson RJ; McLaughlin S; Shaw JS
Bioorg Med Chem Lett; 2005 Jan; 15(1):25-8. PubMed ID: 15582404
[TBL] [Abstract][Full Text] [Related]
19. Expression and characterization of the chemokine receptor CCR2B from rhesus monkey.
Jin H; Vicario PP; Zweerink H; Goyal S; Hanlon WA; Dorn CP; Mills SG; DeMartino JA; Cascieri MA; Struthers M
Biochem Pharmacol; 2003 Jul; 66(2):321-30. PubMed ID: 12826275
[TBL] [Abstract][Full Text] [Related]
20. Indole-2-carboxamides as allosteric modulators of the cannabinoid CB₁ receptor.
Piscitelli F; Ligresti A; La Regina G; Coluccia A; Morera L; Allarà M; Novellino E; Di Marzo V; Silvestri R
J Med Chem; 2012 Jun; 55(11):5627-31. PubMed ID: 22571451
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
