BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

321 related articles for article (PubMed ID: 10975528)

  • 1. Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
    Lei M; Lu W; Meng W; Parrini MC; Eck MJ; Mayer BJ; Harrison SC
    Cell; 2000 Aug; 102(3):387-97. PubMed ID: 10975528
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein.
    Abdul-Manan N; Aghazadeh B; Liu GA; Majumdar A; Ouerfelli O; Siminovitch KA; Rosen MK
    Nature; 1999 May; 399(6734):379-83. PubMed ID: 10360578
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure of Cdc42 bound to the GTPase binding domain of PAK.
    Morreale A; Venkatesan M; Mott HR; Owen D; Nietlispach D; Lowe PN; Laue ED
    Nat Struct Biol; 2000 May; 7(5):384-8. PubMed ID: 10802735
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases.
    Pirruccello M; Sondermann H; Pelton JG; Pellicena P; Hoelz A; Chernoff J; Wemmer DE; Kuriyan J
    J Mol Biol; 2006 Aug; 361(2):312-26. PubMed ID: 16837009
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Localization of the PAK1-, WASP-, and IQGAP1-specifying regions of Cdc42.
    Li R; Debreceni B; Jia B; Gao Y; Tigyi G; Zheng Y
    J Biol Chem; 1999 Oct; 274(42):29648-54. PubMed ID: 10514434
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1.
    Parrini MC; Lei M; Harrison SC; Mayer BJ
    Mol Cell; 2002 Jan; 9(1):73-83. PubMed ID: 11804587
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The active conformation of the PAK1 kinase domain.
    Lei M; Robinson MA; Harrison SC
    Structure; 2005 May; 13(5):769-78. PubMed ID: 15893667
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Delineation of the Cdc42/Rac-binding domain of p21-activated kinase.
    Thompson G; Owen D; Chalk PA; Lowe PN
    Biochemistry; 1998 May; 37(21):7885-91. PubMed ID: 9601050
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation.
    Rudolph MG; Bayer P; Abo A; Kuhlmann J; Vetter IR; Wittinghofer A
    J Biol Chem; 1998 Jul; 273(29):18067-76. PubMed ID: 9660763
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells.
    Daniels RH; Hall PS; Bokoch GM
    EMBO J; 1998 Feb; 17(3):754-64. PubMed ID: 9451000
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains.
    Wang L; Zhu K; Zheng Y
    Biochemistry; 2004 Nov; 43(46):14584-93. PubMed ID: 15544329
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.
    Bokoch GM; Reilly AM; Daniels RH; King CC; Olivera A; Spiegel S; Knaus UG
    J Biol Chem; 1998 Apr; 273(14):8137-44. PubMed ID: 9525917
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.
    Edwards DC; Sanders LC; Bokoch GM; Gill GN
    Nat Cell Biol; 1999 Sep; 1(5):253-9. PubMed ID: 10559936
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2.
    Hoelz A; Janz JM; Lawrie SD; Corwin B; Lee A; Sakmar TP
    J Mol Biol; 2006 Apr; 358(2):509-22. PubMed ID: 16527308
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Association of PI-3 kinase with PAK1 leads to actin phosphorylation and cytoskeletal reorganization.
    Papakonstanti EA; Stournaras C
    Mol Biol Cell; 2002 Aug; 13(8):2946-62. PubMed ID: 12181358
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity.
    Zenke FT; King CC; Bohl BP; Bokoch GM
    J Biol Chem; 1999 Nov; 274(46):32565-73. PubMed ID: 10551809
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Global disruption of the WASP autoinhibited structure on Cdc42 binding. Ligand displacement as a novel method for monitoring amide hydrogen exchange.
    Buck M; Xu W; Rosen MK
    Biochemistry; 2001 Nov; 40(47):14115-22. PubMed ID: 11714264
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Genetic evidence for Pak1 autoinhibition and its release by Cdc42.
    Tu H; Wigler M
    Mol Cell Biol; 1999 Jan; 19(1):602-11. PubMed ID: 9858584
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1.
    Vadlamudi RK; Li F; Adam L; Nguyen D; Ohta Y; Stossel TP; Kumar R
    Nat Cell Biol; 2002 Sep; 4(9):681-90. PubMed ID: 12198493
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of the binding surface on Cdc42Hs for p21-activated kinase.
    Guo W; Sutcliffe MJ; Cerione RA; Oswald RE
    Biochemistry; 1998 Oct; 37(40):14030-7. PubMed ID: 9760238
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.