BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

173 related articles for article (PubMed ID: 10978152)

  • 21. Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.
    Schneider A; Corona A; Spöring I; Jordan M; Buchholz B; Maccioni E; Di Santo R; Bodem J; Tramontano E; Wöhrl BM
    Nucleic Acids Res; 2016 Mar; 44(5):2310-22. PubMed ID: 26850643
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Substitution of conserved hydrophobic residues in motifs B and C of HIV-1 RT alters the geometry of its catalytic pocket.
    Sharma B; Kaushik N; Singh K; Kumar S; Pandey VN
    Biochemistry; 2002 Dec; 41(52):15685-97. PubMed ID: 12501197
    [TBL] [Abstract][Full Text] [Related]  

  • 23. The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alpha-boranophosphate nucleotide analogues.
    Deval J; Selmi B; Boretto J; Egloff MP; Guerreiro C; Sarfati S; Canard B
    J Biol Chem; 2002 Nov; 277(44):42097-104. PubMed ID: 12194983
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Interactions of the HIV-1 reverse transcriptase 'AZT-resistant' mutant with substrates and AZT-TP.
    Pokholok DK; Gudima SO; Yesipov DS; Dobrynin VN; Rechinsky VO; Kochetkov SN
    FEBS Lett; 1993 Jul; 325(3):237-41. PubMed ID: 7686510
    [TBL] [Abstract][Full Text] [Related]  

  • 25. The Y181C substitution in 3'-azido-3'-deoxythymidine-resistant human immunodeficiency virus, type 1, reverse transcriptase suppresses the ATP-mediated repair of the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer.
    Selmi B; Deval J; Alvarez K; Boretto J; Sarfati S; Guerreiro C; Canard B
    J Biol Chem; 2003 Oct; 278(42):40464-72. PubMed ID: 12902345
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Mechanistic insights into the role of Val75 of HIV-1 reverse transcriptase in misinsertion and mispair extension fidelity of DNA synthesis.
    Matamoros T; Kim B; Menéndez-Arias L
    J Mol Biol; 2008 Feb; 375(5):1234-48. PubMed ID: 18155043
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase.
    Arion D; Kaushik N; McCormick S; Borkow G; Parniak MA
    Biochemistry; 1998 Nov; 37(45):15908-17. PubMed ID: 9843396
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Sensitivity of HIV-1 reverse transcriptase and its mutants to inhibition by azidothymidine triphosphate.
    Carroll SS; Geib J; Olsen DB; Stahlhut M; Shafer JA; Kuo LC
    Biochemistry; 1994 Mar; 33(8):2113-20. PubMed ID: 7509634
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Enzymatic properties of two mutants of reverse transcriptase of human immunodeficiency virus type 1 (tyrosine 181-->isoleucine and tyrosine 188-->leucine), resistant to nonnucleoside inhibitors.
    Loya S; Bakhanashvili M; Tal R; Hughes SH; Boyer PL; Hizi A
    AIDS Res Hum Retroviruses; 1994 Aug; 10(8):939-46. PubMed ID: 7529032
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Pre-steady-state kinetic characterization of wild type and 3'-azido-3'-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance.
    Kerr SG; Anderson KS
    Biochemistry; 1997 Nov; 36(46):14064-70. PubMed ID: 9369478
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Lysine 152 of MuLV reverse transcriptase is required for the integrity of the active site.
    Shi Q; Singh K; Srivastava A; Kaushik N; Modak MJ
    Biochemistry; 2002 Dec; 41(50):14831-42. PubMed ID: 12475231
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Studies on the effects of truncating alpha-helix E' of p66 human immunodeficiency virus type 1 reverse transcriptase on template-primer binding and fidelity of DNA synthesis.
    Menéndez-Arias L
    Biochemistry; 1998 Nov; 37(47):16636-44. PubMed ID: 9843431
    [TBL] [Abstract][Full Text] [Related]  

  • 33. The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.
    Gao HQ; Boyer PL; Sarafianos SG; Arnold E; Hughes SH
    J Mol Biol; 2000 Jul; 300(2):403-18. PubMed ID: 10873473
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA.
    Peletskaya EN; Kogon AA; Tuske S; Arnold E; Hughes SH
    J Virol; 2004 Apr; 78(7):3387-97. PubMed ID: 15016861
    [TBL] [Abstract][Full Text] [Related]  

  • 35. K65R and K65A substitutions in HIV-1 reverse transcriptase enhance polymerase fidelity by decreasing both dNTP misinsertion and mispaired primer extension efficiencies.
    Garforth SJ; Domaoal RA; Lwatula C; Landau MJ; Meyer AJ; Anderson KS; Prasad VR
    J Mol Biol; 2010 Aug; 401(1):33-44. PubMed ID: 20538005
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Functional analysis of amino acid residues constituting the dNTP binding pocket of HIV-1 reverse transcriptase.
    Harris D; Kaushik N; Pandey PK; Yadav PN; Pandey VN
    J Biol Chem; 1998 Dec; 273(50):33624-34. PubMed ID: 9837947
    [TBL] [Abstract][Full Text] [Related]  

  • 37. A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase.
    Meyer PR; Matsuura SE; Mian AM; So AG; Scott WA
    Mol Cell; 1999 Jul; 4(1):35-43. PubMed ID: 10445025
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The processivity of DNA synthesis exhibited by drug-resistant variants of human immunodeficiency virus type-1 reverse transcriptase.
    Avidan O; Hizi A
    Nucleic Acids Res; 1998 Apr; 26(7):1713-7. PubMed ID: 9512543
    [TBL] [Abstract][Full Text] [Related]  

  • 39. A positively charged side chain at position 154 on the beta8-alphaE loop of HIV-1 RT is required for stable ternary complex formation.
    Sharma B; Kaushik N; Upadhyay A; Tripathi S; Singh K; Pandey VN
    Nucleic Acids Res; 2003 Sep; 31(17):5167-74. PubMed ID: 12930968
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision.
    Boyer PL; Imamichi T; Sarafianos SG; Arnold E; Hughes SH
    J Virol; 2004 Sep; 78(18):9987-97. PubMed ID: 15331732
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.