161 related articles for article (PubMed ID: 11000545)
1. Species-dependent and site-specific intestinal metabolism of ester prodrugs.
Van Gelder J; Shafiee M; De Clercq E; Penninckx F; Van den Mooter G; Kinget R; Augustijns P
Int J Pharm; 2000 Sep; 205(1-2):93-100. PubMed ID: 11000545
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study.
Van Gelder J; Annaert P; Naesens L; De Clercq E; Van den Mooter G; Kinget R; Augustijns P
Pharm Res; 1999 Jul; 16(7):1035-40. PubMed ID: 10450927
[TBL] [Abstract][Full Text] [Related]
3. Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.
van Gelder J; Deferme S; Naesens L; De Clercq E; van den Mooter G; Kinget R; Augustijns P
Drug Metab Dispos; 2002 Aug; 30(8):924-30. PubMed ID: 12124311
[TBL] [Abstract][Full Text] [Related]
4. Increased absorption of the antiviral ester prodrug tenofovir disoproxil in rat ileum by inhibiting its intestinal metabolism.
Van Gelder J; Deferme S; Annaert P; Naesens L; De Clercq E; Van den Mooter G; Kinget R; Augustijns P
Drug Metab Dispos; 2000 Dec; 28(12):1394-6. PubMed ID: 11095573
[TBL] [Abstract][Full Text] [Related]
5. Development of a Novel Formulation That Improves Preclinical Bioavailability of Tenofovir Disoproxil Fumarate.
Watkins ME; Wring S; Randolph R; Park S; Powell K; Lutz L; Nowakowski M; Ramabhadran R; Domanico PL
J Pharm Sci; 2017 Mar; 106(3):906-919. PubMed ID: 27986599
[TBL] [Abstract][Full Text] [Related]
6. Absorption of ester prodrugs in Caco-2 and rat intestine models.
He X; Sugawara M; Takekuma Y; Miyazaki K
Antimicrob Agents Chemother; 2004 Jul; 48(7):2604-9. PubMed ID: 15215116
[TBL] [Abstract][Full Text] [Related]
7. Intestinal behavior of the ester prodrug tenofovir DF in humans.
Geboers S; Haenen S; Mols R; Brouwers J; Tack J; Annaert P; Augustijns P
Int J Pharm; 2015 May; 485(1-2):131-7. PubMed ID: 25747454
[TBL] [Abstract][Full Text] [Related]
8. Increasing oral absorption of polar neuraminidase inhibitors: a prodrug transporter approach applied to oseltamivir analogue.
Gupta D; Varghese Gupta S; Dahan A; Tsume Y; Hilfinger J; Lee KD; Amidon GL
Mol Pharm; 2013 Feb; 10(2):512-22. PubMed ID: 23244438
[TBL] [Abstract][Full Text] [Related]
9. Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs.
Shaw JP; Sueoko CM; Oliyai R; Lee WA; Arimilli MN; Kim CU; Cundy KC
Pharm Res; 1997 Dec; 14(12):1824-9. PubMed ID: 9453075
[TBL] [Abstract][Full Text] [Related]
10. 5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter.
Han H; de Vrueh RL; Rhie JK; Covitz KM; Smith PL; Lee CP; Oh DM; Sadée W; Amidon GL
Pharm Res; 1998 Aug; 15(8):1154-9. PubMed ID: 9706043
[TBL] [Abstract][Full Text] [Related]
11. Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).
Annaert P; Kinget R; Naesens L; de Clercq E; Augustijns P
Pharm Res; 1997 Apr; 14(4):492-6. PubMed ID: 9144737
[TBL] [Abstract][Full Text] [Related]
12. Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
Annaert P; Gosselin G; Pompon A; Benzaria S; Valette G; Imbach JL; Naesens L; Hatse S; de Clercq E; Van den Mooter G; Kinget R; Augustijns P
Pharm Res; 1998 Feb; 15(2):239-45. PubMed ID: 9523310
[TBL] [Abstract][Full Text] [Related]
13. [Ester prodrug of scutellarin: synthesis, physicochemical property and degradation].
Cao F; Guo JX; Ping QN; Shao Y; Liang J
Yao Xue Xue Bao; 2006 Jul; 41(7):595-602. PubMed ID: 17007349
[TBL] [Abstract][Full Text] [Related]
14. Development of a novel system for estimating human intestinal absorption using Caco-2 cells in the absence of esterase activity.
Ohura K; Sakamoto H; Ninomiya S; Imai T
Drug Metab Dispos; 2010 Feb; 38(2):323-31. PubMed ID: 19923255
[TBL] [Abstract][Full Text] [Related]
15. Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers.
Bak A; Gudmundsson OS; Friis GJ; Siahaan TJ; Borchardt RT
Pharm Res; 1999 Jan; 16(1):24-9. PubMed ID: 9950274
[TBL] [Abstract][Full Text] [Related]
16. Species dependent esterase activities for hydrolysis of an anti-HIV prodrug glycovir and bioavailability of active SC-48334.
Cook CS; Karabatsos PJ; Schoenhard GL; Karim A
Pharm Res; 1995 Aug; 12(8):1158-64. PubMed ID: 7494828
[TBL] [Abstract][Full Text] [Related]
17. Transport of levovirin prodrugs in the human intestinal Caco-2 cell line.
Li F; Hong L; Mau CI; Chan R; Hendricks T; Dvorak C; Yee C; Harris J; Alfredson T
J Pharm Sci; 2006 Jun; 95(6):1318-25. PubMed ID: 16634069
[TBL] [Abstract][Full Text] [Related]
18. Species differences in the disposition of propranolol prodrugs derived from hydrolase activity in intestinal mucosa.
Yoshigae Y; Imai T; Aso T; Otagiri M
Life Sci; 1998; 62(14):1231-41. PubMed ID: 9570338
[TBL] [Abstract][Full Text] [Related]
19. Esterase-sensitive cyclic prodrugs of peptides: evaluation of an acyloxyalkoxy promoiety in a model hexapeptide.
Pauletti GM; Gangwar S; Okumu FW; Siahaan TJ; Stella VJ; Borchardt RT
Pharm Res; 1996 Nov; 13(11):1615-23. PubMed ID: 8956324
[TBL] [Abstract][Full Text] [Related]
20. Bifunctional peptidomimetic prodrugs of didanosine for improved intestinal permeability and enhanced acidic stability: synthesis, transepithelial transport, chemical stability and pharmacokinetics.
Yan Z; Sun J; Chang Y; Liu Y; Fu Q; Xu Y; Sun Y; Pu X; Zhang Y; Jing Y; Yin S; Zhu M; Wang Y; He Z
Mol Pharm; 2011 Apr; 8(2):319-29. PubMed ID: 21280612
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
