BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

398 related articles for article (PubMed ID: 11016631)

  • 1. Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Su T; Bao Z; Zhang QY; Smith TJ; Hong JY; Ding X
    Cancer Res; 2000 Sep; 60(18):5074-9. PubMed ID: 11016631
    [TBL] [Abstract][Full Text] [Related]  

  • 2. CYP2A13: variable expression and role in human lung microsomal metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Zhang X; D'Agostino J; Wu H; Zhang QY; von Weymarn L; Murphy SE; Ding X
    J Pharmacol Exp Ther; 2007 Nov; 323(2):570-8. PubMed ID: 17671098
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nasal cytochrome P450 2A: identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen.
    Thornton-Manning JR; Nikula KJ; Hotchkiss JA; Avila KJ; Rohrbacher KD; Ding X; Dahl AR
    Toxicol Appl Pharmacol; 1997 Jan; 142(1):22-30. PubMed ID: 9007030
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.
    Wang H; Tan W; Hao B; Miao X; Zhou G; He F; Lin D
    Cancer Res; 2003 Nov; 63(22):8057-61. PubMed ID: 14633739
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen.
    He XY; Shen J; Ding X; Lu AY; Hong JY
    Drug Metab Dispos; 2004 Dec; 32(12):1516-21. PubMed ID: 15333516
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Analysis of CYP2A contributions to metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human peripheral lung microsomes.
    Brown PJ; Bedard LL; Reid KR; Petsikas D; Massey TE
    Drug Metab Dispos; 2007 Nov; 35(11):2086-94. PubMed ID: 17717079
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.
    Chiang HC; Wang CY; Lee HL; Tsou TC
    Toxicol Appl Pharmacol; 2011 Jun; 253(2):145-52. PubMed ID: 21473878
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cytochrome P450 2A of nasal epithelium: regulation and role in carcinogen metabolism.
    Béréziat JC; Raffalli F; Schmezer P; Frei E; Geneste O; Lang MA
    Mol Carcinog; 1995 Oct; 14(2):130-9. PubMed ID: 7576100
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Evidence for metabolic activation of N'-nitrosonornicotine and N-nitrosobenzylmethylamine by a rat nasal coumarin hydroxylase.
    Patten CJ; Peterson LA; Murphy SE
    Drug Metab Dispos; 1998 Feb; 26(2):177-80. PubMed ID: 9456305
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.
    Megaraj V; Zhou X; Xie F; Liu Z; Yang W; Ding X
    Carcinogenesis; 2014 Jan; 35(1):131-7. PubMed ID: 23917075
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2a6: role in metabolic activation of nasal toxicants.
    Liu C; Zhuo X; Gonzalez FJ; Ding X
    Mol Pharmacol; 1996 Oct; 50(4):781-8. PubMed ID: 8863822
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Human CYP2A6 activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): mutational specificity in the gpt gene of AS52 cells.
    Tiano HF; Wang RL; Hosokawa M; Crespi C; Tindall KR; Langenbach R
    Carcinogenesis; 1994 Dec; 15(12):2859-66. PubMed ID: 8001247
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation.
    He XY; Shen J; Hu WY; Ding X; Lu AY; Hong JY
    Arch Biochem Biophys; 2004 Jul; 427(2):143-53. PubMed ID: 15196988
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Expression of CYP2A genes in human liver and extrahepatic tissues.
    Koskela S; Hakkola J; Hukkanen J; Pelkonen O; Sorri M; Saranen A; Anttila S; Fernandez-Salguero P; Gonzalez F; Raunio H
    Biochem Pharmacol; 1999 Jun; 57(12):1407-13. PubMed ID: 10353262
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.
    Chiang HC; Wang CK; Tsou TC
    Respiration; 2012; 84(4):319-26. PubMed ID: 22890016
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Human cytochrome p450 2s1: lack of activity in the metabolic activation of several cigarette smoke carcinogens and in the metabolism of nicotine.
    Wang SL; He XY; Hong JY
    Drug Metab Dispos; 2005 Mar; 33(3):336-40. PubMed ID: 15608128
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development of a Salmonella tester strain sensitive to promutagenic N-nitrosamines: expression of recombinant CYP2A6 and human NADPH-cytochrome P450 reductase in S. typhimurium YG7108.
    Kushida H; Fujita K; Suzuki A; Yamada M; Nohmi T; Kamataki T
    Mutat Res; 2000 Nov; 471(1-2):135-43. PubMed ID: 11080669
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
    Tiano HF; Hosokawa M; Chulada PC; Smith PB; Wang RL; Gonzalez FJ; Crespi CL; Langenbach R
    Carcinogenesis; 1993 Jul; 14(7):1421-7. PubMed ID: 8330360
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Expression of cytochrome P450 2A3 in rat esophagus: relevance to N-nitrosobenzylmethylamine.
    Gopalakrishnan R; Morse MA; Lu J; Weghorst CM; Sabourin CL; Stoner GD; Murphy SE
    Carcinogenesis; 1999 May; 20(5):885-91. PubMed ID: 10334207
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes.
    Yamazaki H; Inui Y; Yun CH; Guengerich FP; Shimada T
    Carcinogenesis; 1992 Oct; 13(10):1789-94. PubMed ID: 1423839
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.