379 related articles for article (PubMed ID: 11016953)
1. HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase.
Espeseth AS; Felock P; Wolfe A; Witmer M; Grobler J; Anthony N; Egbertson M; Melamed JY; Young S; Hamill T; Cole JL; Hazuda DJ
Proc Natl Acad Sci U S A; 2000 Oct; 97(21):11244-9. PubMed ID: 11016953
[TBL] [Abstract][Full Text] [Related]
2. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.
Hazuda DJ; Felock P; Witmer M; Wolfe A; Stillmock K; Grobler JA; Espeseth A; Gabryelski L; Schleif W; Blau C; Miller MD
Science; 2000 Jan; 287(5453):646-50. PubMed ID: 10649997
[TBL] [Abstract][Full Text] [Related]
3. Structural determinants for HIV-1 integrase inhibition by beta-diketo acids.
Marchand C; Zhang X; Pais GC; Cowansage K; Neamati N; Burke TR; Pommier Y
J Biol Chem; 2002 Apr; 277(15):12596-603. PubMed ID: 11805103
[TBL] [Abstract][Full Text] [Related]
4. Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.
Chen X; Tsiang M; Yu F; Hung M; Jones GS; Zeynalzadegan A; Qi X; Jin H; Kim CU; Swaminathan S; Chen JM
J Mol Biol; 2008 Jul; 380(3):504-19. PubMed ID: 18565342
[TBL] [Abstract][Full Text] [Related]
5. Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.
Johnson AA; Sayer JM; Yagi H; Patil SS; Debart F; Maier MA; Corey DR; Vasseur JJ; Burke TR; Marquez VE; Jerina DM; Pommier Y
J Biol Chem; 2006 Oct; 281(43):32428-38. PubMed ID: 16943199
[TBL] [Abstract][Full Text] [Related]
6. Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors.
Dicker IB; Samanta HK; Li Z; Hong Y; Tian Y; Banville J; Remillard RR; Walker MA; Langley DR; Krystal M
J Biol Chem; 2007 Oct; 282(43):31186-96. PubMed ID: 17715137
[TBL] [Abstract][Full Text] [Related]
7. Human immunodeficiency virus type-1 integrase containing a glycine to serine mutation at position 140 is attenuated for catalysis and resistant to integrase inhibitors.
King PJ; Lee DJ; Reinke RA; Victoria JG; Beale K; Robinson WE
Virology; 2003 Feb; 306(1):147-61. PubMed ID: 12620807
[TBL] [Abstract][Full Text] [Related]
8. Dissecting Tn5 transposition using HIV-1 integrase diketoacid inhibitors.
Czyz A; Stillmock KA; Hazuda DJ; Reznikoff WS
Biochemistry; 2007 Sep; 46(38):10776-89. PubMed ID: 17725323
[TBL] [Abstract][Full Text] [Related]
9. In vitro assays for activities of retroviral integrase.
Chow SA
Methods; 1997 Aug; 12(4):306-17. PubMed ID: 9245611
[TBL] [Abstract][Full Text] [Related]
10. In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate.
Savarino A
Retrovirology; 2007 Mar; 4():21. PubMed ID: 17374162
[TBL] [Abstract][Full Text] [Related]
11. Hyrtiosal, from the marine sponge Hyrtios erectus, inhibits HIV-1 integrase binding to viral DNA by a new inhibitor binding site.
Du L; Shen L; Yu Z; Chen J; Guo Y; Tang Y; Shen X; Jiang H
ChemMedChem; 2008 Jan; 3(1):173-80. PubMed ID: 17943714
[TBL] [Abstract][Full Text] [Related]
12. Biochemical screening assays to identify HIV-1 integrase inhibitors.
Clynhens M; Smets A; Vereycken I; Van Loock M; Clayton R; Meersseman G; Goethals O
Methods Mol Biol; 2013; 1030():25-36. PubMed ID: 23821258
[TBL] [Abstract][Full Text] [Related]
13. Resistance to HIV-1 integrase inhibitors: A structural perspective.
Mouscadet JF; Delelis O; Marcelin AG; Tchertanov L
Drug Resist Updat; 2010; 13(4-5):139-50. PubMed ID: 20570551
[TBL] [Abstract][Full Text] [Related]
14. L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro.
Reinke RA; Lee DJ; McDougall BR; King PJ; Victoria J; Mao Y; Lei X; Reinecke MG; Robinson WE
Virology; 2004 Sep; 326(2):203-19. PubMed ID: 15302207
[TBL] [Abstract][Full Text] [Related]
15. Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations.
Fikkert V; Van Maele B; Vercammen J; Hantson A; Van Remoortel B; Michiels M; Gurnari C; Pannecouque C; De Maeyer M; Engelborghs Y; De Clercq E; Debyser Z; Witvrouw M
J Virol; 2003 Nov; 77(21):11459-70. PubMed ID: 14557631
[TBL] [Abstract][Full Text] [Related]
16. Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions.
Svarovskaia ES; Barr R; Zhang X; Pais GC; Marchand C; Pommier Y; Burke TR; Pathak VK
J Virol; 2004 Apr; 78(7):3210-22. PubMed ID: 15016842
[TBL] [Abstract][Full Text] [Related]
17. The use of a new in vitro reaction substrate reproducing both U3 and U5 regions of the HIV-1 3'-ends increases the correlation between the in vitro and in vivo effects of the HIV-1 integrase inhibitors.
Tramontano E; Onidi L; Esposito F; Badas R; La Colla P
Biochem Pharmacol; 2004 May; 67(9):1751-61. PubMed ID: 15081874
[TBL] [Abstract][Full Text] [Related]
18. Inhibition of human immunodeficiency virus type 1 isolates by the integrase inhibitor L-731,988, a diketo Acid.
Reinke R; Lee DJ; Robinson WE
Antimicrob Agents Chemother; 2002 Oct; 46(10):3301-3. PubMed ID: 12234866
[TBL] [Abstract][Full Text] [Related]
19. Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.
Grobler JA; Stillmock K; Hu B; Witmer M; Felock P; Espeseth AS; Wolfe A; Egbertson M; Bourgeois M; Melamed J; Wai JS; Young S; Vacca J; Hazuda DJ
Proc Natl Acad Sci U S A; 2002 May; 99(10):6661-6. PubMed ID: 11997448
[TBL] [Abstract][Full Text] [Related]
20. Development of a fluorescence-based HIV-1 integrase DNA binding assay for identification of novel HIV-1 integrase inhibitors.
Han YS; Xiao WL; Quashie PK; Mesplède T; Xu H; Deprez E; Delelis O; Pu JX; Sun HD; Wainberg MA
Antiviral Res; 2013 Jun; 98(3):441-8. PubMed ID: 23583286
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]