These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

345 related articles for article (PubMed ID: 11018743)

  • 1. Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens.
    Seo KY; Jelinsky SA; Loechler EL
    Mutat Res; 2000 Oct; 463(3):215-46. PubMed ID: 11018743
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Toward an understanding of the role of DNA adduct conformation in defining mutagenic mechanism based on studies of the major adduct (formed at N(2)-dG) of the potent environmental carcinogen, benzo[a]pyrene.
    Kozack R; Seo KY; Jelinsky SA; Loechler EL
    Mutat Res; 2000 May; 450(1-2):41-59. PubMed ID: 10838133
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The major, N2-dG adduct of (+)-anti-B[a]PDE shows a dramatically different mutagenic specificity (predominantly, G --> A) in a 5'-CGT-3' sequence context.
    Shukla R; Liu T; Geacintov NE; Loechler EL
    Biochemistry; 1997 Aug; 36(33):10256-61. PubMed ID: 9254624
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular modeling of the major adduct of (+)-anti-B[a]PDE (N2-dG) in the eight conformations and the five DNA sequences most relevant to base substitution mutagenesis.
    Kozack RE; Loechler EL
    Carcinogenesis; 1999 Jan; 20(1):85-94. PubMed ID: 9934854
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mutagenesis by the (+)-anti-diol epoxide of benzo[a]pyrene: what controls mutagenic specificity?
    Rodriguez H; Loechler EL
    Biochemistry; 1993 Feb; 32(7):1759-69. PubMed ID: 8439538
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular modeling of the major benzo[a]pyrene N2-dG adduct in cases where mutagenesis results are known in double stranded DNA.
    Lee CH; Loechler EL
    Mutat Res; 2003 Aug; 529(1-2):59-76. PubMed ID: 12943920
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular modeling of four stereoisomers of the major B[a]PDE adduct (at N(2)-dG) in five cases where the structure is known from NMR studies: molecular modeling is consistent with NMR results.
    Lee CH; Chandani S; Loechler EL
    Chem Res Toxicol; 2002 Nov; 15(11):1429-44. PubMed ID: 12437334
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Evading the proofreading machinery of a replicative DNA polymerase: induction of a mutation by an environmental carcinogen.
    Perlow RA; Broyde S
    J Mol Biol; 2001 Jun; 309(2):519-36. PubMed ID: 11371169
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The major, N2-Gua adduct of the (+)-anti-benzo[a]pyrene diol epoxide is capable of inducing G-->A and G-->C, in addition to G-->T, mutations.
    Jelinsky SA; Liu T; Geacintov NE; Loechler EL
    Biochemistry; 1995 Oct; 34(41):13545-53. PubMed ID: 7577943
    [TBL] [Abstract][Full Text] [Related]  

  • 10. DNA adducts from a tumorigenic metabolite of benzo[a]pyrene block human RNA polymerase II elongation in a sequence- and stereochemistry-dependent manner.
    Perlow RA; Kolbanovskii A; Hingerty BE; Geacintov NE; Broyde S; Scicchitano DA
    J Mol Biol; 2002 Aug; 321(1):29-47. PubMed ID: 12139931
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A hypothesis for what conformation of the major adduct of (+)-anti-B[a]PDE (N2-dG) causes G-->T versus G-->A mutations based upon a correlation between mutagenesis and molecular modeling results.
    Kozack RE; Shukla R; Loechler EL
    Carcinogenesis; 1999 Jan; 20(1):95-102. PubMed ID: 9934855
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Free-energy perturbation methods to study structure and energetics of DNA adducts: results for the major N2-dG adduct of benzo[a]pyrene in two conformations and different sequence contexts.
    Chandani S; Lee CH; Loechler EL
    Chem Res Toxicol; 2005 Jul; 18(7):1108-23. PubMed ID: 16022503
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A role for DNA polymerase V in G --> T mutations from the major benzo[a]pyrene N2-dG adduct when studied in a 5'-TGT sequence in E. coli.
    Yin J; Seo KY; Loechler EL
    DNA Repair (Amst); 2004 Mar; 3(3):323-34. PubMed ID: 15177047
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mutagenesis studies with four stereoisomeric N2-dG benzo[a]pyrene adducts in the identical 5'-CGC sequence used in NMR studies: G->T mutations dominate in each case.
    Seo KY; Nagalingam A; Tiffany M; Loechler EL
    Mutagenesis; 2005 Nov; 20(6):441-8. PubMed ID: 16311255
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Molecular modeling of the conformational complexity of (+)-anti-B[a]PDE-adducted DNA using simulated annealing.
    Kozack RE; Loechler EL
    Carcinogenesis; 1997 Aug; 18(8):1585-93. PubMed ID: 9276634
    [TBL] [Abstract][Full Text] [Related]  

  • 16. AP sites are not significantly involved in mutagenesis by the (+)-anti diol epoxide of benzo[a]pyrene: the complexity of its mutagenic specificity is likely to arise from adduct conformational polymorphism.
    Drouin EE; Loechler EL
    Biochemistry; 1993 Jul; 32(26):6555-62. PubMed ID: 7687146
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The major, N2-dG adduct of (+)-anti-B[a]PDE induces G-->A mutations in a 5'-AGA-3' sequence context.
    Shukla R; Geacintov NE; Loechler EL
    Carcinogenesis; 1999 Feb; 20(2):261-8. PubMed ID: 10069463
    [TBL] [Abstract][Full Text] [Related]  

  • 18. How are potent bulky carcinogens able to induce such a diverse array of mutations?
    Loechler EL
    Mol Carcinog; 1995 Aug; 13(4):213-9. PubMed ID: 7646760
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Toward understanding the mutagenicity of an environmental carcinogen: structural insights into nucleotide incorporation preferences.
    Perlow RA; Broyde S
    J Mol Biol; 2002 Sep; 322(2):291-309. PubMed ID: 12217692
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Y-Family DNA polymerases may use two different dNTP shapes for insertion: a hypothesis and its implications.
    Chandani S; Loechler EL
    J Mol Graph Model; 2009 Apr; 27(7):759-69. PubMed ID: 19188081
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.