233 related articles for article (PubMed ID: 11040033)
1. Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5.
Shapiro DA; Kristiansen K; Kroeze WK; Roth BL
Mol Pharmacol; 2000 Nov; 58(5):877-86. PubMed ID: 11040033
[TBL] [Abstract][Full Text] [Related]
2. Site-directed mutagenesis of the serotonin 5-hydroxytrypamine2 receptor: identification of amino acids necessary for ligand binding and receptor activation.
Wang CD; Gallaher TK; Shih JC
Mol Pharmacol; 1993 Jun; 43(6):931-40. PubMed ID: 8316224
[TBL] [Abstract][Full Text] [Related]
3. Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves.
Kurrasch-Orbaugh DM; Watts VJ; Barker EL; Nichols DE
J Pharmacol Exp Ther; 2003 Jan; 304(1):229-37. PubMed ID: 12490596
[TBL] [Abstract][Full Text] [Related]
4. Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines.
Blair JB; Kurrasch-Orbaugh D; Marona-Lewicka D; Cumbay MG; Watts VJ; Barker EL; Nichols DE
J Med Chem; 2000 Nov; 43(24):4701-10. PubMed ID: 11101361
[TBL] [Abstract][Full Text] [Related]
5. A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism.
Kristiansen K; Kroeze WK; Willins DL; Gelber EI; Savage JE; Glennon RA; Roth BL
J Pharmacol Exp Ther; 2000 Jun; 293(3):735-46. PubMed ID: 10869371
[TBL] [Abstract][Full Text] [Related]
6. Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines.
Johnson MP; Loncharich RJ; Baez M; Nelson DL
Mol Pharmacol; 1994 Feb; 45(2):277-86. PubMed ID: 8114677
[TBL] [Abstract][Full Text] [Related]
7. Role of 5-HT(2) receptors in the tryptamine-induced 5-HT syndrome in rats.
Van Oekelen D; Megens A; Meert T; Luyten WH; Leysen JE
Behav Pharmacol; 2002 Jul; 13(4):313-8. PubMed ID: 12218512
[TBL] [Abstract][Full Text] [Related]
8. A single point mutation (Phe340-->Leu340) of a conserved phenylalanine abolishes 4-[125I]iodo-(2,5-dimethoxy)phenylisopropylamine and [3H]mesulergine but not [3H]ketanserin binding to 5-hydroxytryptamine2 receptors.
Choudhary MS; Craigo S; Roth BL
Mol Pharmacol; 1993 May; 43(5):755-61. PubMed ID: 8388989
[TBL] [Abstract][Full Text] [Related]
9. Identification of conserved aromatic residues essential for agonist binding and second messenger production at 5-hydroxytryptamine2A receptors.
Roth BL; Shoham M; Choudhary MS; Khan N
Mol Pharmacol; 1997 Aug; 52(2):259-66. PubMed ID: 9271348
[TBL] [Abstract][Full Text] [Related]
10. Mutations of transmembrane IV and V serines indicate that all tryptamines do not bind to the rat 5-HT2A receptor in the same manner.
Johnson MP; Wainscott DB; Lucaites VL; Baez M; Nelson DL
Brain Res Mol Brain Res; 1997 Oct; 49(1-2):1-6. PubMed ID: 9387857
[TBL] [Abstract][Full Text] [Related]
11. Radiolabelling of the human 5-HT2A receptor with an agonist, a partial agonist and an antagonist: effects on apparent agonist affinities.
Sleight AJ; Stam NJ; Mutel V; Vanderheyden PM
Biochem Pharmacol; 1996 Jan; 51(1):71-6. PubMed ID: 8534270
[TBL] [Abstract][Full Text] [Related]
12. High-affinity agonist binding is not sufficient for agonist efficacy at 5-hydroxytryptamine2A receptors: evidence in favor of a modified ternary complex model.
Roth BL; Choudhary MS; Khan N; Uluer AZ
J Pharmacol Exp Ther; 1997 Feb; 280(2):576-83. PubMed ID: 9023266
[TBL] [Abstract][Full Text] [Related]
13. Contribution of a helix 5 locus to selectivity of hallucinogenic and nonhallucinogenic ligands for the human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors: direct and indirect effects on ligand affinity mediated by the same locus.
Almaula N; Ebersole BJ; Ballesteros JA; Weinstein H; Sealfon SC
Mol Pharmacol; 1996 Jul; 50(1):34-42. PubMed ID: 8700116
[TBL] [Abstract][Full Text] [Related]
14. Site-directed mutagenesis of the 5-HT1B receptor increases the affinity of 5-HT for the agonist low-affinity conformation and reduces the intrinsic activity of 5-HT.
Grånäs C; Nordquist J; Mohell N; Larhammar D
Eur J Pharmacol; 2001 Jun; 421(2):69-76. PubMed ID: 11399261
[TBL] [Abstract][Full Text] [Related]
15. Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6.
Shapiro DA; Kristiansen K; Weiner DM; Kroeze WK; Roth BL
J Biol Chem; 2002 Mar; 277(13):11441-9. PubMed ID: 11801601
[TBL] [Abstract][Full Text] [Related]
16. High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.
Fitzgerald LW; Conklin DS; Krause CM; Marshall AP; Patterson JP; Tran DP; Iyer G; Kostich WA; Largent BL; Hartig PR
J Neurochem; 1999 May; 72(5):2127-34. PubMed ID: 10217294
[TBL] [Abstract][Full Text] [Related]
17. Pharmacological characteristics and regulation of 5-HT receptor-stimulated phosphoinositide hydrolysis in the rat spinal cord.
Toscano E; Romero G; Oset C; Del Río J
Gen Pharmacol; 1999 Mar; 32(3):351-8. PubMed ID: 10211591
[TBL] [Abstract][Full Text] [Related]
18. Exploration of the ligand binding site of the human 5-HT(4) receptor by site-directed mutagenesis and molecular modeling.
Mialet J; Dahmoune Y; Lezoualc'h F; Berque-Bestel I; Eftekhari P; Hoebeke J; Sicsic S; Langlois M; Fischmeister R
Br J Pharmacol; 2000 Jun; 130(3):527-38. PubMed ID: 10821780
[TBL] [Abstract][Full Text] [Related]
19. Interaction of tryptamine and ergoline compounds with threonine 196 in the ligand binding site of the 5-hydroxytryptamine6 receptor.
Boess FG; Monsma FJ; Meyer V; Zwingelstein C; Sleight AJ
Mol Pharmacol; 1997 Sep; 52(3):515-23. PubMed ID: 9284367
[TBL] [Abstract][Full Text] [Related]
20. Identification of amino acid residues important for sarpogrelate binding to the human 5-hydroxytryptamine2A serotonin receptor.
Muntasir HA; Rashid M; Komiyama T; Kawakami J; Nagatomo T
J Pharmacol Sci; 2006 Sep; 102(1):55-63. PubMed ID: 16974069
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
