129 related articles for article (PubMed ID: 11043605)
1. Identification by differential display of the IF1 inhibitor peptide of ATP synthase/ATPase as a gene inducible in rat liver by pregnenolone 16alpha-carbonitrile.
Jiménez BD; Quattrochi LC; Yockey CB; Guzelian PS
Life Sci; 2000 Sep; 67(15):1825-32. PubMed ID: 11043605
[TBL] [Abstract][Full Text] [Related]
2. Ectopic expression of MHC class II genes (RT1.B(I) beta/alpha) in rat hepatocytes in vivo and in culture can be elicited by treatment with the pregnane X receptor agonists pregnenolone 16 alpha-carbonitrile and dexamethasone.
Jiménez BD; Maldonado L; Dahl RH; Quattrochi LC; Guzelian PS
Life Sci; 2002 Jun; 71(3):311-23. PubMed ID: 12034349
[TBL] [Abstract][Full Text] [Related]
3. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.
Haines C; Chatham LR; Vardy A; Elcombe CR; Foster JR; Lake BG
Toxicology; 2018 May; 400-401():20-27. PubMed ID: 29548889
[TBL] [Abstract][Full Text] [Related]
4. Expression of cytochromes P450 3A in mouse lung: effects of dexamethasone and pregnenolone 16alpha-carbonitrile.
Haag M; Fautrel A; Guillouzo A; Frossard N; Pons F
Arch Toxicol; 2003 Mar; 77(3):145-9. PubMed ID: 12632254
[TBL] [Abstract][Full Text] [Related]
5. Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats.
Guzelian J; Barwick JL; Hunter L; Phang TL; Quattrochi LC; Guzelian PS
Toxicol Sci; 2006 Dec; 94(2):379-87. PubMed ID: 16997903
[TBL] [Abstract][Full Text] [Related]
6. Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes.
Burger HJ; Schuetz JD; Schuetz EG; Guzelian PS
Proc Natl Acad Sci U S A; 1992 Mar; 89(6):2145-9. PubMed ID: 1372436
[TBL] [Abstract][Full Text] [Related]
7. p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile.
Nelson DM; Bhaskaran V; Foster WR; Lehman-McKeeman LD
Toxicol Sci; 2006 Dec; 94(2):272-80. PubMed ID: 17000718
[TBL] [Abstract][Full Text] [Related]
8. Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.
Marek CJ; Tucker SJ; Konstantinou DK; Elrick LJ; Haefner D; Sigalas C; Murray GI; Goodwin B; Wright MC
Biochem J; 2005 May; 387(Pt 3):601-8. PubMed ID: 15595924
[TBL] [Abstract][Full Text] [Related]
9. Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver.
Guo GL; Johnson DR; Klaassen CD
Drug Metab Dispos; 2002 Mar; 30(3):283-8. PubMed ID: 11854146
[TBL] [Abstract][Full Text] [Related]
10. Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence that glucocorticoids and pregnenolone 16 alpha-carbonitrile regulate de novo synthesis of a common form of cytochrome P-450 in cultures of adult rat hepatocytes and in the liver in vivo.
Schuetz EG; Wrighton SA; Barwick JL; Guzelian PS
J Biol Chem; 1984 Feb; 259(3):1999-2006. PubMed ID: 6141167
[TBL] [Abstract][Full Text] [Related]
11. A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids.
Quattrochi LC; Mills AS; Barwick JL; Yockey CB; Guzelian PS
J Biol Chem; 1995 Dec; 270(48):28917-23. PubMed ID: 7499421
[TBL] [Abstract][Full Text] [Related]
12. Regulation of hepatic sulfotransferases by steroidal chemicals in rats.
Liu L; Klaassen CD
Drug Metab Dispos; 1996 Aug; 24(8):854-8. PubMed ID: 8869819
[TBL] [Abstract][Full Text] [Related]
13. Microarray analysis on CYPs expression in pregnant rats after treatment with pregnenolone-16alpha-carbonitrile and phenobarbital.
Ejiri N; Katayama K; Kiyosawa N; Baba Y; Doi K
Exp Mol Pathol; 2005 Feb; 78(1):71-7. PubMed ID: 15596064
[TBL] [Abstract][Full Text] [Related]
14. Effect of Pregnenolone 16α-Carbonitrile on the Expression of P-Glycoprotein in the Intestine, Brain and Liver of Mice.
Yamasaki Y; Kobayashi K; Chiba K
Biol Pharm Bull; 2018; 41(6):972-977. PubMed ID: 29863087
[TBL] [Abstract][Full Text] [Related]
15. Alteration of acetaminophen metabolism by sulfate and steroids in primary monolayer hepatocyte cultures of rats and mice.
Seo KW; Oh MH; Choung SY; Kim SJ; Kim HJ
Biol Pharm Bull; 1999 Mar; 22(3):261-4. PubMed ID: 10220281
[TBL] [Abstract][Full Text] [Related]
16. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats.
Haines C; Chatham LR; Vardy A; Elcombe CR; Foster JR; Lake BG
Xenobiotica; 2019 Feb; 49(2):227-238. PubMed ID: 29424600
[TBL] [Abstract][Full Text] [Related]
17. A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile.
Bailey I; Gibson GG; Plant K; Graham M; Plant N
PLoS One; 2011 Feb; 6(2):e16703. PubMed ID: 21311750
[TBL] [Abstract][Full Text] [Related]
18. Identification of Candidate Target Cyp Genes for microRNAs Whose Expression Is Altered by PCN and TCPOBOP, Representative Ligands of PXR and CAR.
Moriya N; Kataoka H; Nishikawa J; Kugawa F
Biol Pharm Bull; 2016 Aug; 39(8):1381-6. PubMed ID: 27237601
[TBL] [Abstract][Full Text] [Related]
19. The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice.
Shizu R; Ishimura M; Nobusawa S; Hosaka T; Sasaki T; Kakizaki S; Yoshinari K
Arch Toxicol; 2021 Mar; 95(3):1089-1102. PubMed ID: 33398415
[TBL] [Abstract][Full Text] [Related]
20. Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation.
Kodama S; Shimura T; Kuribayashi H; Abe T; Yoshinari K
Toxicol Lett; 2017 Apr; 271():58-65. PubMed ID: 28237809
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
