275 related articles for article (PubMed ID: 11046110)
1. Polarized efflux of mono- and diacid metabolites of ME3229, an ester-type prodrug of a glycoprotein IIb/IIIa receptor antagonist, in rat small intestine.
Okudaira N; Komiya I; Sugiyama Y
J Pharmacol Exp Ther; 2000 Nov; 295(2):717-23. PubMed ID: 11046110
[TBL] [Abstract][Full Text] [Related]
2. A study of the intestinal absorption of an ester-type prodrug, ME3229, in rats: active efflux transport as a cause of poor bioavailability of the active drug.
Okudaira N; Tatebayashi T; Speirs GC; Komiya I; Sugiyama Y
J Pharmacol Exp Ther; 2000 Aug; 294(2):580-7. PubMed ID: 10900235
[TBL] [Abstract][Full Text] [Related]
3. Lack of improvement of oral absorption of ME3277 by prodrug formation is ascribed to the intestinal efflux mediated by breast cancer resistant protein (BCRP/ABCG2).
Kondo C; Onuki R; Kusuhara H; Suzuki H; Suzuki M; Okudaira N; Kojima M; Ishiwata K; Jonker JW; Sugiyama Y
Pharm Res; 2005 Apr; 22(4):613-8. PubMed ID: 15846469
[TBL] [Abstract][Full Text] [Related]
4. In vitro and in vivo evaluations of intestinal barriers for the zwitterion L-767,679 and its carboxyl ester prodrug L-775,318. Roles of efflux and metabolism.
Prueksaritanont T; DeLuna P; Gorham LM; Ma B; Cohn D; Pang J; Xu X; Leung K; Lin JH
Drug Metab Dispos; 1998 Jun; 26(6):520-7. PubMed ID: 9616186
[TBL] [Abstract][Full Text] [Related]
5. Segmental dependent transport of low permeability compounds along the small intestine due to P-glycoprotein: the role of efflux transport in the oral absorption of BCS class III drugs.
Dahan A; Amidon GL
Mol Pharm; 2009; 6(1):19-28. PubMed ID: 19248230
[TBL] [Abstract][Full Text] [Related]
6. Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2.
Collett A; Higgs NB; Sims E; Rowland M; Warhurst G
J Pharmacol Exp Ther; 1999 Jan; 288(1):171-8. PubMed ID: 9862768
[TBL] [Abstract][Full Text] [Related]
7. Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia.
Stephens RH; O'Neill CA; Warhurst A; Carlson GL; Rowland M; Warhurst G
J Pharmacol Exp Ther; 2001 Feb; 296(2):584-91. PubMed ID: 11160647
[TBL] [Abstract][Full Text] [Related]
8. Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds.
Yumoto R; Murakami T; Nakamoto Y; Hasegawa R; Nagai J; Takano M
J Pharmacol Exp Ther; 1999 Apr; 289(1):149-55. PubMed ID: 10086998
[TBL] [Abstract][Full Text] [Related]
9. Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine.
Dahan A; Sabit H; Amidon GL
Drug Metab Dispos; 2009 Oct; 37(10):2028-36. PubMed ID: 19589874
[TBL] [Abstract][Full Text] [Related]
10. Stereoselective and multiple carrier-mediated transport of cetirizine across Caco-2 cell monolayers with potential drug interaction.
He Y; Liu Y; Zeng S
Chirality; 2010 Jul; 22(7):684-92. PubMed ID: 20014242
[TBL] [Abstract][Full Text] [Related]
11. The complexity of intestinal absorption and exsorption of digoxin in rats.
Yao HM; Chiou WL
Int J Pharm; 2006 Sep; 322(1-2):79-86. PubMed ID: 16781832
[TBL] [Abstract][Full Text] [Related]
12. Transport characteristics of 9-nitrocamptothecin in the human intestinal cell line Caco-2 and everted gut sacs.
Sha X; Fang X
Int J Pharm; 2004 Mar; 272(1-2):161-71. PubMed ID: 15019079
[TBL] [Abstract][Full Text] [Related]
13. Acyclovir prodrug for the intestinal di/tri-peptide transporter PEPT1: comparison of in vivo bioavailability in rats and transport in Caco-2 cells.
Thomsen AE; Christensen MS; Bagger MA; Steffansen B
Eur J Pharm Sci; 2004 Dec; 23(4-5):319-25. PubMed ID: 15567284
[TBL] [Abstract][Full Text] [Related]
14. Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells.
Makhey VD; Guo A; Norris DA; Hu P; Yan J; Sinko PJ
Pharm Res; 1998 Aug; 15(8):1160-7. PubMed ID: 9706044
[TBL] [Abstract][Full Text] [Related]
15. Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique.
Fortuna A; Alves G; Falcão A; Soares-da-Silva P
Epilepsia; 2012 Mar; 53(3):529-38. PubMed ID: 22372629
[TBL] [Abstract][Full Text] [Related]
16. The site-specific transport and metabolism of tacrolimus in rat small intestine.
Tamura S; Tokunaga Y; Ibuki R; Amidon GL; Sezaki H; Yamashita S
J Pharmacol Exp Ther; 2003 Jul; 306(1):310-6. PubMed ID: 12676880
[TBL] [Abstract][Full Text] [Related]
17. Thiolated chitosan: development and in vitro evaluation of an oral delivery system for acyclovir.
Palmberger TF; Hombach J; Bernkop-Schnürch A
Int J Pharm; 2008 Feb; 348(1-2):54-60. PubMed ID: 17716840
[TBL] [Abstract][Full Text] [Related]
18. Characterization of jejunal absorption and apical efflux of ropivacaine, lidocaine and bupivacaine in the rat using in situ and in vitro absorption models.
Berggren S; Hoogstraate J; Fagerholm U; Lennernäs H
Eur J Pharm Sci; 2004 Mar; 21(4):553-60. PubMed ID: 14998587
[TBL] [Abstract][Full Text] [Related]
19. Effect of P-glycoprotein on intestinal absorption and brain penetration of antiallergic agent bepotastine besilate.
Ohashi R; Kamikozawa Y; Sugiura M; Fukuda H; Yabuuchi H; Tamai I
Drug Metab Dispos; 2006 May; 34(5):793-9. PubMed ID: 16455807
[TBL] [Abstract][Full Text] [Related]
20. Modulating effect of polyethylene glycol on the intestinal transport and absorption of prednisolone, methylprednisolone and quinidine in rats by in-vitro and in-situ absorption studies.
Shen Q; Li W; Lin Y; Katsumi H; Okada N; Sakane T; Fujita T; Yamamoto A
J Pharm Pharmacol; 2008 Dec; 60(12):1633-41. PubMed ID: 19000368
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
