BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

141 related articles for article (PubMed ID: 11055332)

  • 1. Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor.
    Kozlowski JA; Lowe DB; Guzik HS; Zhou G; Ruperto VB; Duffy RA; McQuade R; Crosby G; Taylor LA; Billard W; Binch H; Lachowicz JE
    Bioorg Med Chem Lett; 2000 Oct; 10(20):2255-7. PubMed ID: 11055332
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists.
    Wang Y; Chackalamannil S; Hu Z; Clader JW; Greenlee W; Billard W; Binch H; Crosby G; Ruperto V; Duffy RA; McQuade R; Lachowicz JE
    Bioorg Med Chem Lett; 2000 Oct; 10(20):2247-50. PubMed ID: 11055330
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Diphenylsulfone muscarinic antagonists: piperidine derivatives with high M2 selectivity and improved potency.
    Billard W; Binch H; Bratzler K; Chen LY; Crosby G; Duffy RA; Dugar S; Lachowicz J; McQuade R; Pushpavanam P; Ruperto VB; Taylor LA; Clader JW
    Bioorg Med Chem Lett; 2000 Oct; 10(19):2209-12. PubMed ID: 11012031
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists.
    Wang Y; Chackalamannil S; Hu Z; Greenlee WJ; Clader J; Boyle CD; Kaminski JJ; Billard W; Binch H; Crosby G; Ruperto V; Duffy RA; Cohen-Williams M; Coffin VL; Cox KA; Grotz DE; Lachowicz JE
    J Med Chem; 2002 Dec; 45(25):5415-8. PubMed ID: 12459007
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Himbacine analogs as muscarinic receptor antagonists--effects of tether and heterocyclic variations.
    Chackalamannil S; Doller D; McQuade R; Ruperto V
    Bioorg Med Chem Lett; 2004 Aug; 14(15):3967-70. PubMed ID: 15225708
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and muscarinic M2 subtype antagonistic activity of unnatural ent-himbacine and an enantiomeric pair of (2'S,6'R)-diepihimbacine.
    Takadoi M; Terashima S
    Bioorg Med Chem Lett; 2002 Oct; 12(20):2871-3. PubMed ID: 12270166
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and synthesis of ether analogues as potent and selective M2 muscarinic receptor antagonists.
    Wang Y; Chackalamannil S; Chang W; Greenlee W; Ruperto V; Duffy RA; McQuade R; Lachowicz JE
    Bioorg Med Chem Lett; 2001 Apr; 11(7):891-4. PubMed ID: 11294385
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Use of antimuscarinic toxins to facilitate studies of striatal m4 muscarinic receptors.
    Purkerson SL; Potter LT
    J Pharmacol Exp Ther; 1998 Feb; 284(2):707-13. PubMed ID: 9454818
    [TBL] [Abstract][Full Text] [Related]  

  • 9. SCH 57790: a novel M2 receptor selective antagonist.
    Lachowicz JE; Lowe D; Duffy RA; Ruperto V; Taylor LA; Guzik H; Brown J; Berger JG; Tice M; McQuade R; Kozlowski J; Clader J; Strader CD; Murgolo N
    Life Sci; 1999; 64(6-7):535-9. PubMed ID: 10069520
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Facilitation of acetylcholine release and improvement in cognition by a selective M2 muscarinic antagonist, SCH 72788.
    Lachowicz JE; Duffy RA; Ruperto V; Kozlowski J; Zhou G; Clader J; Billard W; Binch H; Crosby G; Cohen-Williams M; Strader CD; Coffin V
    Life Sci; 2001 Apr; 68(22-23):2585-92. PubMed ID: 11392630
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel imidazole derivatives with subtype-selective antimuscarinic activity (2).
    Miyachi H; Kiyota H; Segawa M
    Bioorg Med Chem Lett; 1998 Aug; 8(16):2163-8. PubMed ID: 9873506
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Binding and functional selectivity of himbacine for cloned and neuronal muscarinic receptors.
    Miller JH; Aagaard PJ; Gibson VA; McKinney M
    J Pharmacol Exp Ther; 1992 Nov; 263(2):663-7. PubMed ID: 1331410
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and biological evaluation of phenylacetyl derivatives having low central nervous system permeability as potent and selective M2 muscarinic receptor antagonists.
    Watanabe T; Kakefuda A; Tanaka A; Takizawa K; Hirano S; Shibata H; Yamagiwa Y; Yanagisawa I
    Chem Pharm Bull (Tokyo); 1998 Jan; 46(1):53-68. PubMed ID: 9468637
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthetic studies on himbacine, a potent antagonist of the muscarinic M2 subtype receptor. Part 2: synthesis and muscarinic M2 subtype antagonistic activity of the novel himbacine congeners modified at the C-3 position of lactone moiety.
    Takadoi M; Yamaguchi K; Terashima S
    Bioorg Med Chem; 2003 Apr; 11(7):1169-86. PubMed ID: 12628644
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution.
    Boyle CD; Chackalamannil S; Clader JW; Greenlee WJ; Josien HB; Kaminski JJ; Kozlowski JA; McCombie SW; Nazareno DV; Tagat JR; Wang Y; Zhou G; Billard W; Binch H; Crosby G; Cohen-Williams M; Coffin VL; Cox KA; Grotz DE; Duffy RA; Ruperto V; Lachowicz JE
    Bioorg Med Chem Lett; 2001 Sep; 11(17):2311-4. PubMed ID: 11527721
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and affinity studies of himbacine derived muscarinic receptor antagonists.
    Gao LJ; Waelbroeck M; Hofman S; Van Haver D; Milanesio M; Viterbo D; De Clercq PJ
    Bioorg Med Chem Lett; 2002 Aug; 12(15):1909-12. PubMed ID: 12113806
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and muscarinic M(2) subtype antagonistic activity of enantiomeric pairs of 3-demethylhimbacine (3-norhimbacine) and its C(4)-epimer.
    Takadoi M; Yamaguchi K; Terashima S
    Bioorg Med Chem Lett; 2002 Nov; 12(22):3271-3. PubMed ID: 12392730
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and antimuscarinic activity of some ether- and thioether-bearing 1,3-dioxolanes and related sulfoxides and sulfones.
    Malmusi L; Franchini S; Mucci A; Schenetti L; Gulini U; Marucci G; Brasili L
    Bioorg Med Chem; 1998 Jun; 6(6):825-32. PubMed ID: 9681148
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A potent, long-acting, orally active (2R)-2-[(1R)-3, 3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: novel muscarinic M(3) receptor antagonist with high selectivity for M(3) over M(2) receptors.
    Mitsuya M; Kobayashi K; Kawakami K; Satoh A; Ogino Y; Kakikawa T; Ohtake N; Kimura T; Hirose H; Sato A; Numazawa T; Hasegawa T; Noguchi K; Mase T
    J Med Chem; 2000 Dec; 43(26):5017-29. PubMed ID: 11150173
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of a muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors among 2-[(1S,3S)-3-sulfonylaminocyclopentyl]phenylacetamide derivatives.
    Mitsuya M; Ogino Y; Kawakami K; Uchiyama M; Kimura T; Numazawa T; Hasegawa T; Ohtake N; Noguchi K; Mase T
    Bioorg Med Chem; 2000 Apr; 8(4):825-32. PubMed ID: 10819171
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.