BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

307 related articles for article (PubMed ID: 11083922)

  • 1. ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.
    Hussain I; Powell DJ; Howlett DR; Chapman GA; Gilmour L; Murdock PR; Tew DG; Meek TD; Chapman C; Schneider K; Ratcliffe SJ; Tattersall D; Testa TT; Southan C; Ryan DM; Simmons DL; Walsh FS; Dingwall C; Christie G
    Mol Cell Neurosci; 2000 Nov; 16(5):609-19. PubMed ID: 11083922
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
    Sinha S; Anderson JP; Barbour R; Basi GS; Caccavello R; Davis D; Doan M; Dovey HF; Frigon N; Hong J; Jacobson-Croak K; Jewett N; Keim P; Knops J; Lieberburg I; Power M; Tan H; Tatsuno G; Tung J; Schenk D; Seubert P; Suomensaari SM; Wang S; Walker D; Zhao J; McConlogue L; John V
    Nature; 1999 Dec; 402(6761):537-40. PubMed ID: 10591214
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
    Yan R; Bienkowski MJ; Shuck ME; Miao H; Tory MC; Pauley AM; Brashier JR; Stratman NC; Mathews WR; Buhl AE; Carter DB; Tomasselli AG; Parodi LA; Heinrikson RL; Gurney ME
    Nature; 1999 Dec; 402(6761):533-7. PubMed ID: 10591213
    [TBL] [Abstract][Full Text] [Related]  

  • 4. BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
    Farzan M; Schnitzler CE; Vasilieva N; Leung D; Choe H
    Proc Natl Acad Sci U S A; 2000 Aug; 97(17):9712-7. PubMed ID: 10931940
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of a novel aspartic protease (Asp 2) as beta-secretase.
    Hussain I; Powell D; Howlett DR; Tew DG; Meek TD; Chapman C; Gloger IS; Murphy KE; Southan CD; Ryan DM; Smith TS; Simmons DL; Walsh FS; Dingwall C; Christie G
    Mol Cell Neurosci; 1999 Dec; 14(6):419-27. PubMed ID: 10656250
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
    Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.
    Sauder JM; Arthur JW; Dunbrack RL
    J Mol Biol; 2000 Jul; 300(2):241-8. PubMed ID: 10873463
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
    J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
    J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.
    Stockley JH; O'Neill C
    Biochem Soc Trans; 2007 Jun; 35(Pt 3):574-6. PubMed ID: 17511655
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Intracellular generation of amyloid beta-protein from amyloid beta-protein precursor fragment by direct cleavage with beta- and gamma-secretase.
    Iizuka T; Shoji M; Kawarabayashi T; Sato M; Kobayashi T; Tada N; Kasai K; Matsubara E; Watanabe M; Tomidokoro Y; Hirai S
    Biochem Biophys Res Commun; 1996 Jan; 218(1):238-42. PubMed ID: 8573139
    [TBL] [Abstract][Full Text] [Related]  

  • 13. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.
    Walsh DM; Fadeeva JV; LaVoie MJ; Paliga K; Eggert S; Kimberly WT; Wasco W; Selkoe DJ
    Biochemistry; 2003 Jun; 42(22):6664-73. PubMed ID: 12779321
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease.
    Johnston JA; Liu WW; Todd SA; Coulson DT; Murphy S; Irvine GB; Passmore AP
    Biochem Soc Trans; 2005 Nov; 33(Pt 5):1096-100. PubMed ID: 16246054
    [TBL] [Abstract][Full Text] [Related]  

  • 15. gamma-Secretase can cleave amyloid precursor protein fragments independent of alpha- and beta-secretase pre-cutting.
    Kume H; Sekijima Y; Maruyama K; Kametani F
    Int J Mol Med; 2003 Jul; 12(1):57-60. PubMed ID: 12792809
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
    Hoke DE; Tan JL; Ilaya NT; Culvenor JG; Smith SJ; White AR; Masters CL; Evin GM
    FEBS J; 2005 Nov; 272(21):5544-57. PubMed ID: 16262694
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation.
    Tanahashi H; Tabira T
    Neurosci Lett; 2007 Nov; 428(2-3):103-8. PubMed ID: 17961921
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel alpha-secretase cleavage of Alzheimer's amyloid beta precursor protein in the endoplasmic reticulum of COS7 cells.
    Shin RW; Saido TC; Maeda M; Kitamoto T
    Neurosci Lett; 2005 Mar; 376(1):14-9. PubMed ID: 15694266
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage.
    Kume H; Maruyama K; Kametani F
    Int J Mol Med; 2004 Jan; 13(1):121-5. PubMed ID: 14654982
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes.
    Kinoshita A; Fukumoto H; Shah T; Whelan CM; Irizarry MC; Hyman BT
    J Cell Sci; 2003 Aug; 116(Pt 16):3339-46. PubMed ID: 12829747
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.