BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

288 related articles for article (PubMed ID: 11095592)

  • 1. A convenient in vitro screening method for predicting in vivo drug metabolic clearance using isolated hepatocytes suspended in serum.
    Shibata Y; Takahashi H; Ishii Y
    Drug Metab Dispos; 2000 Dec; 28(12):1518-23. PubMed ID: 11095592
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes.
    Riley RJ; McGinnity DF; Austin RP
    Drug Metab Dispos; 2005 Sep; 33(9):1304-11. PubMed ID: 15932954
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes.
    Blanchard N; Richert L; Notter B; Delobel F; David P; Coassolo P; Lavé T
    Eur J Pharm Sci; 2004 Oct; 23(2):189-99. PubMed ID: 15451007
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo.
    Soars MG; Grime K; Sproston JL; Webborn PJ; Riley RJ
    Drug Metab Dispos; 2007 Jun; 35(6):859-65. PubMed ID: 17344337
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Prediction of the hepatic and renal clearance of transporter substrates in rats using in vitro uptake experiments.
    Watanabe T; Maeda K; Kondo T; Nakayama H; Horita S; Kusuhara H; Sugiyama Y
    Drug Metab Dispos; 2009 Jul; 37(7):1471-9. PubMed ID: 19364828
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.
    Naritomi Y; Terashita S; Kimura S; Suzuki A; Kagayama A; Sugiyama Y
    Drug Metab Dispos; 2001 Oct; 29(10):1316-24. PubMed ID: 11560875
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Investigation of the rate-determining process in the hepatic elimination of HMG-CoA reductase inhibitors in rats and humans.
    Watanabe T; Kusuhara H; Maeda K; Kanamaru H; Saito Y; Hu Z; Sugiyama Y
    Drug Metab Dispos; 2010 Feb; 38(2):215-22. PubMed ID: 19875501
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance.
    Griffin SJ; Houston JB
    Drug Metab Dispos; 2004 May; 32(5):552-8. PubMed ID: 15100178
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations.
    Jones HM; Houston JB
    Drug Metab Dispos; 2004 Sep; 32(9):973-82. PubMed ID: 15319339
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.
    Fagerholm U
    J Pharm Pharmacol; 2007 Jun; 59(6):803-28. PubMed ID: 17637173
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Prediction of human pharmacokinetics--improving microsome-based predictions of hepatic metabolic clearance.
    Fagerholm U
    J Pharm Pharmacol; 2007 Oct; 59(10):1427-31. PubMed ID: 17910819
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss): determination of trout hepatocellularity, optimization of cell concentrations and comparison of serum and serum-free incubations.
    Han X; Mingoia RT; Nabb DL; Yang CH; Snajdr SI; Hoke RA
    Aquat Toxicol; 2008 Aug; 89(1):11-7. PubMed ID: 18599132
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations.
    Blanchard N; Hewitt NJ; Silber P; Jones H; Coassolo P; Lavé T
    J Pharm Pharmacol; 2006 May; 58(5):633-41. PubMed ID: 16640832
    [TBL] [Abstract][Full Text] [Related]  

  • 14. In vitro-in vivo correlation of the pharmacokinetics of vinpocetine.
    Szakács T; Veres Z; Vereczkey L
    Pol J Pharmacol; 2001; 53(6):623-8. PubMed ID: 11985336
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Use of intrinsic clearance for prediction of human hepatic clearance.
    Chao P; Uss AS; Cheng KC
    Expert Opin Drug Metab Toxicol; 2010 Feb; 6(2):189-98. PubMed ID: 20073997
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Uptake and intracellular binding of lipophilic amine drugs by isolated rat hepatocytes and implications for prediction of in vivo metabolic clearance.
    Hallifax D; Houston JB
    Drug Metab Dispos; 2006 Nov; 34(11):1829-36. PubMed ID: 16882765
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Effect of plasma protein binding on in vitro-in vivo correlation of biliary excretion of drugs evaluated by sandwich-cultured rat hepatocytes.
    Fukuda H; Ohashi R; Tsuda-Tsukimoto M; Tamai I
    Drug Metab Dispos; 2008 Jul; 36(7):1275-82. PubMed ID: 18388177
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction.
    de Graaf IA; de Kanter R; de Jager MH; Camacho R; Langenkamp E; van de Kerkhof EG; Groothuis GM
    Drug Metab Dispos; 2006 Apr; 34(4):591-9. PubMed ID: 16415126
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Direct determination of the ratio of unbound fraction in plasma to unbound fraction in microsomal system (fu p/fu mic) for refined prediction of phase I mediated metabolic hepatic clearance.
    Deshmukh SV; Harsch A
    J Pharmacol Toxicol Methods; 2011; 63(1):35-9. PubMed ID: 20433934
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.
    Miners JO; Knights KM; Houston JB; Mackenzie PI
    Biochem Pharmacol; 2006 May; 71(11):1531-9. PubMed ID: 16455060
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.