BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

649 related articles for article (PubMed ID: 11114265)

  • 1. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
    Xia W; Ostaszewski BL; Kimberly WT; Rahmati T; Moore CL; Wolfe MS; Selkoe DJ
    Neurobiol Dis; 2000 Dec; 7(6 Pt B):673-81. PubMed ID: 11114265
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
    Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
    Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
    Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
    Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
    J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
    J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Generation of amyloid beta protein from a presenilin-1 and betaAPP complex.
    Shizuka-Ikeda M; Matsubara E; Ikeda M; Kanai M; Tomidokoro Y; Ikeda Y; Watanabe M; Kawarabayashi T; Harigaya Y; Okamoto K; Maruyama K; Castaño EM; St George-Hyslop P; Shoji M
    Biochem Biophys Res Commun; 2002 Mar; 292(2):571-8. PubMed ID: 11906199
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
    De Strooper B; Saftig P; Craessaerts K; Vanderstichele H; Guhde G; Annaert W; Von Figura K; Van Leuven F
    Nature; 1998 Jan; 391(6665):387-90. PubMed ID: 9450754
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
    Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?
    Knappenberger KS; Tian G; Ye X; Sobotka-Briner C; Ghanekar SV; Greenberg BD; Scott CW
    Biochemistry; 2004 May; 43(20):6208-18. PubMed ID: 15147205
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
    Esler WP; Kimberly WT; Ostaszewski BL; Diehl TS; Moore CL; Tsai JY; Rahmati T; Xia W; Selkoe DJ; Wolfe MS
    Nat Cell Biol; 2000 Jul; 2(7):428-34. PubMed ID: 10878808
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes.
    Wang J; Brunkan AL; Hecimovic S; Walker E; Goate A
    Neurobiol Dis; 2004 Apr; 15(3):654-66. PubMed ID: 15056474
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Down-regulation amyloid beta-protein 42 production by interfering with transcript of presenilin 1 gene with siRNA.
    Luo HM; Deng H; Xiao F; Gao Q; Weng W; Zhang PF; Li XG
    Acta Pharmacol Sin; 2004 Dec; 25(12):1613-8. PubMed ID: 15569405
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
    Steiner H; Winkler E; Shearman MS; Prywes R; Haass C
    Neurobiol Dis; 2001 Aug; 8(4):717-22. PubMed ID: 11493036
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
    De Strooper B; Annaert W; Cupers P; Saftig P; Craessaerts K; Mumm JS; Schroeter EH; Schrijvers V; Wolfe MS; Ray WJ; Goate A; Kopan R
    Nature; 1999 Apr; 398(6727):518-22. PubMed ID: 10206645
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G; Zhu A; Holsinger RM; Masters CL; Li QX
    J Neurosci Res; 2003 Nov; 74(3):386-92. PubMed ID: 14598315
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
    Yan R; Bienkowski MJ; Shuck ME; Miao H; Tory MC; Pauley AM; Brashier JR; Stratman NC; Mathews WR; Buhl AE; Carter DB; Tomasselli AG; Parodi LA; Heinrikson RL; Gurney ME
    Nature; 1999 Dec; 402(6761):533-7. PubMed ID: 10591213
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
    Lai MT; Crouthamel MC; DiMuzio J; Pietrak BL; Donoviel DB; Bernstein A; Gardell SJ; Li YM; Hazuda D
    J Neurochem; 2006 Jan; 96(1):118-25. PubMed ID: 16300640
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
    Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; Masters CL
    Biochemistry; 2005 Mar; 44(11):4332-41. PubMed ID: 15766262
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 33.