649 related articles for article (PubMed ID: 11114265)
21. Proprotein convertase activity contributes to the processing of the Alzheimer's beta-amyloid precursor protein in human cells: evidence for a role of the prohormone convertase PC7 in the constitutive alpha-secretase pathway.
Lopez-Perez E; Seidah NG; Checler F
J Neurochem; 1999 Nov; 73(5):2056-62. PubMed ID: 10537065
[TBL] [Abstract][Full Text] [Related]
22. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
Esposito L; Gan L; Yu GQ; Essrich C; Mucke L
J Neurochem; 2004 Dec; 91(6):1260-74. PubMed ID: 15584903
[TBL] [Abstract][Full Text] [Related]
23. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.
Laudon H; Mathews PM; Karlström H; Bergman A; Farmery MR; Nixon RA; Winblad B; Gandy SE; Lendahl U; Lundkvist J; Näslund J
J Neurochem; 2004 Apr; 89(1):44-53. PubMed ID: 15030388
[TBL] [Abstract][Full Text] [Related]
24. Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells.
Verdile G; Groth D; Mathews PM; St George-Hyslop P; Fraser PE; Ramabhadran TV; Kwok JB; Schofield PR; Carter T; Gandy S; Martins RN
Mol Psychiatry; 2004 Jun; 9(6):594-602. PubMed ID: 14993906
[TBL] [Abstract][Full Text] [Related]
25. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.
Wrigley JD; Nunn EJ; Nyabi O; Clarke EE; Hunt P; Nadin A; De Strooper B; Shearman MS; Beher D
J Neurochem; 2004 Sep; 90(6):1312-20. PubMed ID: 15341515
[TBL] [Abstract][Full Text] [Related]
26. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
[TBL] [Abstract][Full Text] [Related]
27. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Citron M; Eckman CB; Diehl TS; Corcoran C; Ostaszewski BL; Xia W; Levesque G; St George Hyslop P; Younkin SG; Selkoe DJ
Neurobiol Dis; 1998 Aug; 5(2):107-16. PubMed ID: 9746908
[TBL] [Abstract][Full Text] [Related]
28. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; Nishimura M; Yanagisawa K; Komano H
J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
[TBL] [Abstract][Full Text] [Related]
29. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains.
Wahrle S; Das P; Nyborg AC; McLendon C; Shoji M; Kawarabayashi T; Younkin LH; Younkin SG; Golde TE
Neurobiol Dis; 2002 Feb; 9(1):11-23. PubMed ID: 11848681
[TBL] [Abstract][Full Text] [Related]
30. Overexpression of calsenilin enhances gamma-secretase activity.
Jo DG; Jang J; Kim BJ; Lundkvist J; Jung YK
Neurosci Lett; 2005 Apr; 378(1):59-64. PubMed ID: 15763173
[TBL] [Abstract][Full Text] [Related]
31. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
Walker ES; Martinez M; Brunkan AL; Goate A
J Neurochem; 2005 Jan; 92(2):294-301. PubMed ID: 15663477
[TBL] [Abstract][Full Text] [Related]
32. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
Hoke DE; Tan JL; Ilaya NT; Culvenor JG; Smith SJ; White AR; Masters CL; Evin GM
FEBS J; 2005 Nov; 272(21):5544-57. PubMed ID: 16262694
[TBL] [Abstract][Full Text] [Related]
33. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain.
Siman R; Salidas S
Neuroscience; 2004; 129(3):615-28. PubMed ID: 15541883
[TBL] [Abstract][Full Text] [Related]
34. Alzheimer's disease. Molecular consequences of presenilin-1 mutation.
Gandy S; Naslund J; Nordstedt C
Nature; 2001 Jun; 411(6838):654-6. PubMed ID: 11395757
[TBL] [Abstract][Full Text] [Related]
35. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
Cupers P; Bentahir M; Craessaerts K; Orlans I; Vanderstichele H; Saftig P; De Strooper B; Annaert W
J Cell Biol; 2001 Aug; 154(4):731-40. PubMed ID: 11502763
[TBL] [Abstract][Full Text] [Related]
36. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Kimberly WT; Esler WP; Ye W; Ostaszewski BL; Gao J; Diehl T; Selkoe DJ; Wolfe MS
Biochemistry; 2003 Jan; 42(1):137-44. PubMed ID: 12515548
[TBL] [Abstract][Full Text] [Related]
37. Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.
Evin G; Sharples RA; Weidemann A; Reinhard FB; Carbone V; Culvenor JG; Holsinger RM; Sernee MF; Beyreuther K; Masters CL
Biochemistry; 2001 Jul; 40(28):8359-68. PubMed ID: 11444983
[TBL] [Abstract][Full Text] [Related]
38. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.
Zhang Z; Nadeau P; Song W; Donoviel D; Yuan M; Bernstein A; Yankner BA
Nat Cell Biol; 2000 Jul; 2(7):463-5. PubMed ID: 10878814
[No Abstract] [Full Text] [Related]
39. Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells.
Parvathy S; Hussain I; Karran EH; Turner AJ; Hooper NM
Biochemistry; 1999 Jul; 38(30):9728-34. PubMed ID: 10423252
[TBL] [Abstract][Full Text] [Related]
40. BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
Farzan M; Schnitzler CE; Vasilieva N; Leung D; Choe H
Proc Natl Acad Sci U S A; 2000 Aug; 97(17):9712-7. PubMed ID: 10931940
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]