BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

251 related articles for article (PubMed ID: 11121434)

  • 1. Reversal of the Ras-induced transformed phenotype by HR12, a novel ras farnesylation inhibitor, is mediated by the Mek/Erk pathway.
    Reuveni H; Geiger T; Geiger B; Levitzki A
    J Cell Biol; 2000 Dec; 151(6):1179-92. PubMed ID: 11121434
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest.
    Reuveni H; Klein S; Levitzki A
    Eur J Biochem; 2003 Jul; 270(13):2759-72. PubMed ID: 12823546
    [TBL] [Abstract][Full Text] [Related]  

  • 3. MEK and ERK activation in ras-disabled RBL-2H3 mast cells and novel roles for geranylgeranylated and farnesylated proteins in Fc epsilonRI-mediated signaling.
    Graham TE; Pfeiffer JR; Lee RJ; Kusewitt DF; Martinez AM; Foutz T; Wilson BS; Oliver JM
    J Immunol; 1998 Dec; 161(12):6733-44. PubMed ID: 9862703
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.
    Rusyn EV; Reynolds ER; Shao H; Grana TM; Chan TO; Andres DA; Cox AD
    Oncogene; 2000 Sep; 19(41):4685-94. PubMed ID: 11032018
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Downstream effectors of oncogenic ras in multiple myeloma cells.
    Hu L; Shi Y; Hsu JH; Gera J; Van Ness B; Lichtenstein A
    Blood; 2003 Apr; 101(8):3126-35. PubMed ID: 12515720
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Concomitant activation of the PI3K-Akt and the Ras-ERK signaling pathways is essential for transformation by the V-SEA tyrosine kinase oncogene.
    Agazie Y; Ischenko I; Hayman M
    Oncogene; 2002 Jan; 21(5):697-707. PubMed ID: 11850798
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3.
    Agazie YM; Movilla N; Ischenko I; Hayman MJ
    Oncogene; 2003 Oct; 22(44):6909-18. PubMed ID: 14534538
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts.
    Pawlak G; Helfman DM
    Mol Biol Cell; 2002 Jan; 13(1):336-47. PubMed ID: 11809843
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells.
    Plattner R; Gupta S; Khosravi-Far R; Sato KY; Perucho M; Der CJ; Stanbridge EJ
    Oncogene; 1999 Mar; 18(10):1807-17. PubMed ID: 10086335
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
    Lerner EC; Qian Y; Blaskovich MA; Fossum RD; Vogt A; Sun J; Cox AD; Der CJ; Hamilton AD; Sebti SM
    J Biol Chem; 1995 Nov; 270(45):26802-6. PubMed ID: 7592920
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
    Dai Y; Rahmani M; Pei XY; Khanna P; Han SI; Mitchell C; Dent P; Grant S
    Blood; 2005 Feb; 105(4):1706-16. PubMed ID: 15494423
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Roles of the Ras-MEK-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation of rodent fibroblast and epithelial cell lines.
    Maeda N; Fu W; Ortin A; de las Heras M; Fan H
    J Virol; 2005 Apr; 79(7):4440-50. PubMed ID: 15767444
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phosphatidylinositol 3-kinase and Ras/mitogen-activated protein kinase signaling pathways are required for the regulation of 5-aminolevulinate synthase gene expression by insulin.
    Scassa ME; Guberman AS; Varone CL; Cánepa ET
    Exp Cell Res; 2001 Dec; 271(2):201-13. PubMed ID: 11716532
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras.
    Brassard DL; English JM; Malkowski M; Kirschmeier P; Nagabhushan TL; Bishop WR
    Exp Cell Res; 2002 Feb; 273(2):138-46. PubMed ID: 11822869
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.
    Campbell M; Allen WE; Sawyer C; Vanhaesebroeck B; Trimble ER
    Circ Res; 2004 Aug; 95(4):380-8. PubMed ID: 15242975
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells.
    James G; Goldstein JL; Brown MS
    Proc Natl Acad Sci U S A; 1996 Apr; 93(9):4454-8. PubMed ID: 8633088
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Ras mediates radioresistance through both phosphatidylinositol 3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-independent signaling pathways.
    Grana TM; Rusyn EV; Zhou H; Sartor CI; Cox AD
    Cancer Res; 2002 Jul; 62(14):4142-50. PubMed ID: 12124353
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Ras- and Raf-induced down-modulation of non-muscle tropomyosin are MEK-independent.
    Janssen RA; Veenstra KG; Jonasch P; Jonasch E; Mier JW
    J Biol Chem; 1998 Nov; 273(48):32182-6. PubMed ID: 9822696
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The 96 kDa protein kinase activated by oncogenic Ras in Xenopus egg extracts is also activated by constitutively active Mek: activation requires serine/threonine phosphorylation.
    Pan BT; Zhang Y; Brott B; Chen DH
    Oncogene; 1997 Apr; 14(14):1653-60. PubMed ID: 9135066
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.
    James GL; Brown MS; Cobb MH; Goldstein JL
    J Biol Chem; 1994 Nov; 269(44):27705-14. PubMed ID: 7961691
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.