BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

413 related articles for article (PubMed ID: 11140637)

  • 1. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
    Liu Z; Sun C; Olejniczak ET; Meadows RP; Betz SF; Oost T; Herrmann J; Wu JC; Fesik SW
    Nature; 2000 Dec 21-28; 408(6815):1004-8. PubMed ID: 11140637
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.
    Srinivasula SM; Hegde R; Saleh A; Datta P; Shiozaki E; Chai J; Lee RA; Robbins PD; Fernandes-Alnemri T; Shi Y; Alnemri ES
    Nature; 2001 Mar; 410(6824):112-6. PubMed ID: 11242052
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural basis of IAP recognition by Smac/DIABLO.
    Wu G; Chai J; Suber TL; Wu JW; Du C; Wang X; Shi Y
    Nature; 2000 Dec 21-28; 408(6815):1008-12. PubMed ID: 11140638
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural and biochemical basis of apoptotic activation by Smac/DIABLO.
    Chai J; Du C; Wu JW; Kyin S; Wang X; Shi Y
    Nature; 2000 Aug; 406(6798):855-62. PubMed ID: 10972280
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural basis for bivalent Smac-mimetics recognition in the IAP protein family.
    Cossu F; Milani M; Mastrangelo E; Vachette P; Servida F; Lecis D; Canevari G; Delia D; Drago C; Rizzo V; Manzoni L; Seneci P; Scolastico C; Bolognesi M
    J Mol Biol; 2009 Sep; 392(3):630-44. PubMed ID: 19393243
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Protein-protein recognition as a first step towards the inhibition of XIAP and Survivin anti-apoptotic proteins.
    Obiol-Pardo C; Granadino-Roldán JM; Rubio-Martinez J
    J Mol Recognit; 2008; 21(3):190-204. PubMed ID: 18438971
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Solution structure of human survivin and its binding interface with Smac/Diablo.
    Sun C; Nettesheim D; Liu Z; Olejniczak ET
    Biochemistry; 2005 Jan; 44(1):11-7. PubMed ID: 15628841
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
    Mastrangelo E; Cossu F; Milani M; Sorrentino G; Lecis D; Delia D; Manzoni L; Drago C; Seneci P; Scolastico C; Rizzo V; Bolognesi M
    J Mol Biol; 2008 Dec; 384(3):673-89. PubMed ID: 18851976
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.
    Kulathila R; Vash B; Sage D; Cornell-Kennon S; Wright K; Koehn J; Stams T; Clark K; Price A
    Acta Crystallogr D Biol Crystallogr; 2009 Jan; 65(Pt 1):58-66. PubMed ID: 19153467
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
    Zobel K; Wang L; Varfolomeev E; Franklin MC; Elliott LO; Wallweber HJ; Okawa DC; Flygare JA; Vucic D; Fairbrother WJ; Deshayes K
    ACS Chem Biol; 2006 Sep; 1(8):525-33. PubMed ID: 17168540
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
    Oost TK; Sun C; Armstrong RC; Al-Assaad AS; Betz SF; Deckwerth TL; Ding H; Elmore SW; Meadows RP; Olejniczak ET; Oleksijew A; Oltersdorf T; Rosenberg SH; Shoemaker AR; Tomaselli KJ; Zou H; Fesik SW
    J Med Chem; 2004 Aug; 47(18):4417-26. PubMed ID: 15317454
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.
    Vucic D; Franklin MC; Wallweber HJ; Das K; Eckelman BP; Shin H; Elliott LO; Kadkhodayan S; Deshayes K; Salvesen GS; Fairbrother WJ
    Biochem J; 2005 Jan; 385(Pt 1):11-20. PubMed ID: 15485396
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains.
    Nikolovska-Coleska Z; Meagher JL; Jiang S; Kawamoto SA; Gao W; Yi H; Qin D; Roller PP; Stuckey JA; Wang S
    Anal Biochem; 2008 Mar; 374(1):87-98. PubMed ID: 18023397
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.
    Sun H; Nikolovska-Coleska Z; Yang CY; Xu L; Tomita Y; Krajewski K; Roller PP; Wang S
    J Med Chem; 2004 Aug; 47(17):4147-50. PubMed ID: 15293984
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A mechanistic insight into SMAC peptide interference with XIAP-Bir2 inhibition of executioner caspases.
    Abhari BA; Davoodi J
    J Mol Biol; 2008 Sep; 381(3):645-54. PubMed ID: 18619610
    [TBL] [Abstract][Full Text] [Related]  

  • 16. ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists.
    Bornstein B; Gottfried Y; Edison N; Shekhtman A; Lev T; Glaser F; Larisch S
    Apoptosis; 2011 Sep; 16(9):869-81. PubMed ID: 21695558
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.
    Nikolovska-Coleska Z; Xu L; Hu Z; Tomita Y; Li P; Roller PP; Wang R; Fang X; Guo R; Zhang M; Lippman ME; Yang D; Wang S
    J Med Chem; 2004 May; 47(10):2430-40. PubMed ID: 15115387
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Theoretical studies on the interactions of XIAP-BIR3 domain with bicyclic and tricyclic core monovalent Smac mimetics.
    Ling B; Dong L; Zhang R; Wang Z; Liu Y; Liu C
    J Mol Graph Model; 2010 Nov; 29(3):354-62. PubMed ID: 20980180
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP).
    Franklin MC; Kadkhodayan S; Ackerly H; Alexandru D; Distefano MD; Elliott LO; Flygare JA; Mausisa G; Okawa DC; Ong D; Vucic D; Deshayes K; Fairbrother WJ
    Biochemistry; 2003 Jul; 42(27):8223-31. PubMed ID: 12846571
    [TBL] [Abstract][Full Text] [Related]  

  • 20. NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP.
    Sun C; Cai M; Gunasekera AH; Meadows RP; Wang H; Chen J; Zhang H; Wu W; Xu N; Ng SC; Fesik SW
    Nature; 1999 Oct; 401(6755):818-22. PubMed ID: 10548111
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.