BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

108 related articles for article (PubMed ID: 11170642)

  • 1. Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717.
    Dreyer MK; Borcherding DR; Dumont JA; Peet NP; Tsay JT; Wright PS; Bitonti AJ; Shen J; Kim SH
    J Med Chem; 2001 Feb; 44(4):524-30. PubMed ID: 11170642
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine.
    Schulze-Gahmen U; Brandsen J; Jones HD; Morgan DO; Meijer L; Vesely J; Kim SH
    Proteins; 1995 Aug; 22(4):378-91. PubMed ID: 7479711
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex.
    Legraverend M; Tunnah P; Noble M; Ducrot P; Ludwig O; Grierson DS; Leost M; Meijer L; Endicott J
    J Med Chem; 2000 Apr; 43(7):1282-92. PubMed ID: 10753466
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine.
    De Azevedo WF; Leclerc S; Meijer L; Havlicek L; Strnad M; Kim SH
    Eur J Biochem; 1997 Jan; 243(1-2):518-26. PubMed ID: 9030780
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.
    De Azevedo WF; Mueller-Dieckmann HJ; Schulze-Gahmen U; Worland PJ; Sausville E; Kim SH
    Proc Natl Acad Sci U S A; 1996 Apr; 93(7):2735-40. PubMed ID: 8610110
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
    Russo AA; Jeffrey PD; Patten AK; Massagué J; Pavletich NP
    Nature; 1996 Jul; 382(6589):325-31. PubMed ID: 8684460
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural basis for chemical inhibition of CDK2.
    Kim SH; Schulze-Gahmen U; Brandsen J; de Azevedo Júnior WF
    Prog Cell Cycle Res; 1996; 2():137-45. PubMed ID: 9552391
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular model of cyclin-dependent kinase 5 complexed with roscovitine.
    Filgueira de Azevedo W; Gaspar RT; Canduri F; Camera JC; Freitas da Silveira NJ
    Biochem Biophys Res Commun; 2002 Oct; 297(5):1154-8. PubMed ID: 12372407
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate.
    Davies TG; Tunnah P; Meijer L; Marko D; Eisenbrand G; Endicott JA; Noble ME
    Structure; 2001 May; 9(5):389-97. PubMed ID: 11377199
    [TBL] [Abstract][Full Text] [Related]  

  • 10. X-ray crystallographic studies of CDK2, a basis for cyclin-dependent kinase inhibitor design in anti-cancer drug research.
    Furet P
    Curr Med Chem Anticancer Agents; 2003 Jan; 3(1):15-23. PubMed ID: 12678911
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Docking-based development of purine-like inhibitors of cyclin-dependent kinase-2.
    Otyepka M; Krystof V; Havlícek L; Siglerová V; Strnad M; Koca J
    J Med Chem; 2000 Jun; 43(13):2506-13. PubMed ID: 10891109
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structure of a gamma-herpesvirus cyclin-cdk complex.
    Card GL; Knowles P; Laman H; Jones N; McDonald NQ
    EMBO J; 2000 Jun; 19(12):2877-88. PubMed ID: 10856233
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases.
    Brown NR; Noble ME; Endicott JA; Johnson LN
    Nat Cell Biol; 1999 Nov; 1(7):438-43. PubMed ID: 10559988
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.
    Shewchuk L; Hassell A; Wisely B; Rocque W; Holmes W; Veal J; Kuyper LF
    J Med Chem; 2000 Jan; 43(1):133-8. PubMed ID: 10633045
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
    Lawrie AM; Noble ME; Tunnah P; Brown NR; Johnson LN; Endicott JA
    Nat Struct Biol; 1997 Oct; 4(10):796-801. PubMed ID: 9334743
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Bound to activate: conformational consequences of cyclin binding to CDK2.
    Radzio-Andzelm E; Lew J; Taylor S
    Structure; 1995 Nov; 3(11):1135-41. PubMed ID: 8591024
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Under arrest at atomic resolution.
    Morgan DO
    Nature; 1996 Jul; 382(6589):295-6. PubMed ID: 8684452
    [No Abstract]   [Full Text] [Related]  

  • 18. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects.
    Mettey Y; Gompel M; Thomas V; Garnier M; Leost M; Ceballos-Picot I; Noble M; Endicott J; Vierfond JM; Meijer L
    J Med Chem; 2003 Jan; 46(2):222-36. PubMed ID: 12519061
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 3D-QSAR CoMFA on cyclin-dependent kinase inhibitors.
    Ducrot P; Legraverend M; Grierson DS
    J Med Chem; 2000 Nov; 43(22):4098-108. PubMed ID: 11063606
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
    Gray NS; Wodicka L; Thunnissen AM; Norman TC; Kwon S; Espinoza FH; Morgan DO; Barnes G; LeClerc S; Meijer L; Kim SH; Lockhart DJ; Schultz PG
    Science; 1998 Jul; 281(5376):533-8. PubMed ID: 9677190
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.