278 related articles for article (PubMed ID: 11172670)
1. Syntheses and antitumor activities of potent inhibitors of ribonucleotide reductase: 3-amino-4-methylpyridine-2-carboxaldehyde-thiosemicarba-zone (3-AMP), 3-amino-pyridine-2-carboxaldehyde-thiosemicarbazone (3-AP) and its water-soluble prodrugs.
Li J; Zheng LM; King I; Doyle TW; Chen SH
Curr Med Chem; 2001 Feb; 8(2):121-33. PubMed ID: 11172670
[TBL] [Abstract][Full Text] [Related]
2. Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones.
Cory JG; Cory AH; Rappa G; Lorico A; Liu MC; Lin TS; Sartorelli AC
Biochem Pharmacol; 1994 Jul; 48(2):335-44. PubMed ID: 8053929
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and biological evaluation of a water soluble phosphate prodrug of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP).
Li J; Luo X; Wang Q; Zheng LM; King I; Doyle TW; Chen SH
Bioorg Med Chem Lett; 1998 Nov; 8(22):3159-64. PubMed ID: 9873695
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.
Liu MC; Lin TS; Cory JG; Cory AH; Sartorelli AC
J Med Chem; 1996 Jun; 39(13):2586-93. PubMed ID: 8691457
[TBL] [Abstract][Full Text] [Related]
5. Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase.
Zhu L; Zhou B; Chen X; Jiang H; Shao J; Yen Y
Biochem Pharmacol; 2009 Nov; 78(9):1178-85. PubMed ID: 19576866
[TBL] [Abstract][Full Text] [Related]
6. Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.
Finch RA; Liu M; Grill SP; Rose WC; Loomis R; Vasquez KM; Cheng Y; Sartorelli AC
Biochem Pharmacol; 2000 Apr; 59(8):983-91. PubMed ID: 10692563
[TBL] [Abstract][Full Text] [Related]
7. Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity.
Finch RA; Liu MC; Cory AH; Cory JG; Sartorelli AC
Adv Enzyme Regul; 1999; 39():3-12. PubMed ID: 10470363
[TBL] [Abstract][Full Text] [Related]
8. Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study.
Popović-Bijelić A; Kowol CR; Lind ME; Luo J; Himo F; Enyedy EA; Arion VB; Gräslund A
J Inorg Biochem; 2011 Nov; 105(11):1422-31. PubMed ID: 21955844
[TBL] [Abstract][Full Text] [Related]
9. Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo.
Cory JG; Cory AH; Rappa G; Lorico A; Liu MC; Lin TS; Sartorelli AC
Adv Enzyme Regul; 1995; 35():55-68. PubMed ID: 7572354
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L.
Parker EN; Odutola SO; Wang Y; Strecker TE; Mukherjee R; Shi Z; Chaplin DJ; Trawick ML; Pinney KG
Bioorg Med Chem Lett; 2017 Mar; 27(5):1304-1310. PubMed ID: 28117205
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and antitumor activity of 3- and 5-hydroxy-4-methylpyridine-2-carboxaldehyde thiosemicarbazones.
Wang Y; Liu MC; Lin TS; Sartorelli AC
J Med Chem; 1992 Oct; 35(20):3667-71. PubMed ID: 1433177
[TBL] [Abstract][Full Text] [Related]
12. Activity and electrochemical properties: iron complexes of the anticancer drug triapine and its analogs.
Plamthottam S; Sun D; Van Valkenburgh J; Valenzuela J; Ruehle B; Steele D; Poddar S; Marshalik M; Hernandez S; Radu CG; Zink JI
J Biol Inorg Chem; 2019 Aug; 24(5):621-632. PubMed ID: 31250199
[TBL] [Abstract][Full Text] [Related]
13. Antimicrobial activity of two antitumour agents and ribonucleotide reductase inhibitors, pyridine-2-carboxaldehyde thiosemicarbazone and the acetate form of its copper(II) chelate.
Elo H
Z Naturforsch C J Biosci; 2007; 62(7-8):498-506. PubMed ID: 17913063
[TBL] [Abstract][Full Text] [Related]
14. Potent ribonucleotide reductase inhibitors: Thiazole-containing thiosemicarbazone derivatives.
Ertas M; Sahin Z; Bulbul EF; Bender C; Biltekin SN; Berk B; Yurttas L; Nalbur AM; Celik H; Demirayak Ş
Arch Pharm (Weinheim); 2019 Nov; 352(11):e1900033. PubMed ID: 31475759
[TBL] [Abstract][Full Text] [Related]
15. Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation.
Kowol CR; Trondl R; Heffeter P; Arion VB; Jakupec MA; Roller A; Galanski MS; Berger W; Keppler BK
J Med Chem; 2009 Aug; 52(16):5032-43. PubMed ID: 19637923
[TBL] [Abstract][Full Text] [Related]
16. Alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazone inhibitors of ribonucleoside diphosphate reductase.
Booth BA; Agrawal KC; Moore EC; Sartorelli AC
Cancer Res; 1974 Jun; 34(6):1308-14. PubMed ID: 4363653
[No Abstract] [Full Text] [Related]
17. Evolving role of ribonucleoside reductase inhibitors in hematologic malignancies.
Tsimberidou AM; Alvarado Y; Giles FJ
Expert Rev Anticancer Ther; 2002 Aug; 2(4):437-48. PubMed ID: 12647987
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.
Liu MC; Lin TS; Sartorelli AC
J Med Chem; 1992 Oct; 35(20):3672-7. PubMed ID: 1433178
[TBL] [Abstract][Full Text] [Related]
19. Overexpression of the multidrug resistance genes mdr1, mdr3, and mrp in L1210 leukemia cells resistant to inhibitors of ribonucleotide reductase.
Rappa G; Lorico A; Liu MC; Kruh GD; Cory AH; Cory JG; Sartorelli AC
Biochem Pharmacol; 1997 Sep; 54(6):649-55. PubMed ID: 9310341
[TBL] [Abstract][Full Text] [Related]
20. Design and virtual screening towards synthesis of novel substituted thiosemicarbozones as ribonuleotide reductase (RNR) inhibitors with improved cellular trafficking and anticancer activity.
Gokhale N; Jain S; Yadav M
Curr Top Med Chem; 2015; 15(1):37-42. PubMed ID: 25579572
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]