BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

196 related articles for article (PubMed ID: 11179458)

  • 1. Characterization of recombinant, soluble beta-secretase from an insect cell expression system.
    Mallender WD; Yager D; Onstead L; Nichols MR; Eckman C; Sambamurti K; Kopcho LM; Marcinkeviciene J; Copeland RA; Rosenberry TL
    Mol Pharmacol; 2001 Mar; 59(3):619-26. PubMed ID: 11179458
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles.
    Hook VY; Toneff T; Aaron W; Yasothornsrikul S; Bundey R; Reisine T
    J Neurochem; 2002 Apr; 81(2):237-56. PubMed ID: 12064471
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Recombinant insect cell expression and purification of human beta-secretase (BACE-1) for X-ray crystallography.
    Bruinzeel W; Yon J; Giovannelli S; Masure S
    Protein Expr Purif; 2002 Oct; 26(1):139-48. PubMed ID: 12356481
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
    Vassar R; Bennett BD; Babu-Khan S; Kahn S; Mendiaz EA; Denis P; Teplow DB; Ross S; Amarante P; Loeloff R; Luo Y; Fisher S; Fuller J; Edenson S; Lile J; Jarosinski MA; Biere AL; Curran E; Burgess T; Louis JC; Collins F; Treanor J; Rogers G; Citron M
    Science; 1999 Oct; 286(5440):735-41. PubMed ID: 10531052
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.
    Sauder JM; Arthur JW; Dunbrack RL
    J Mol Biol; 2000 Jul; 300(2):241-8. PubMed ID: 10873463
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients.
    Li R; Lindholm K; Yang LB; Yue X; Citron M; Yan R; Beach T; Sue L; Sabbagh M; Cai H; Wong P; Price D; Shen Y
    Proc Natl Acad Sci U S A; 2004 Mar; 101(10):3632-7. PubMed ID: 14978286
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Expression, purification and activity measurement of soluble BACE protein in E.coli.
    Wei XC; Li H; Ji JG; Li R; Ren YF; Feng JH; Hao FY
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai); 2002 Jul; 34(4):498-501. PubMed ID: 12098775
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.
    Shi XP; Tugusheva K; Bruce JE; Lucka A; Wu GX; Chen-Dodson E; Price E; Li Y; Xu M; Huang Q; Sardana MK; Hazuda DJ
    J Biol Chem; 2003 Jun; 278(23):21286-94. PubMed ID: 12665519
    [TBL] [Abstract][Full Text] [Related]  

  • 9. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
    Roberds SL; Anderson J; Basi G; Bienkowski MJ; Branstetter DG; Chen KS; Freedman SB; Frigon NL; Games D; Hu K; Johnson-Wood K; Kappenman KE; Kawabe TT; Kola I; Kuehn R; Lee M; Liu W; Motter R; Nichols NF; Power M; Robertson DW; Schenk D; Schoor M; Shopp GM; Shuck ME; Sinha S; Svensson KA; Tatsuno G; Tintrup H; Wijsman J; Wright S; McConlogue L
    Hum Mol Genet; 2001 Jun; 10(12):1317-24. PubMed ID: 11406613
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP.
    Boddapati S; Levites Y; Sierks MR
    J Mol Biol; 2011 Jan; 405(2):436-47. PubMed ID: 21073877
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Biochemical and cell-based assays for characterization of BACE-1 inhibitors.
    Pietrak BL; Crouthamel MC; Tugusheva K; Lineberger JE; Xu M; DiMuzio JM; Steele T; Espeseth AS; Stachel SJ; Coburn CA; Graham SL; Vacca JP; Shi XP; Simon AJ; Hazuda DJ; Lai MT
    Anal Biochem; 2005 Jul; 342(1):144-51. PubMed ID: 15958191
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases.
    Grüninger-Leitch F; Schlatter D; Küng E; Nelböck P; Döbeli H
    J Biol Chem; 2002 Feb; 277(7):4687-93. PubMed ID: 11741910
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.
    Gandhi S; Refolo LM; Sambamurti K
    J Mol Neurosci; 2004; 24(1):137-43. PubMed ID: 15314262
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
    Yan R; Bienkowski MJ; Shuck ME; Miao H; Tory MC; Pauley AM; Brashier JR; Stratman NC; Mathews WR; Buhl AE; Carter DB; Tomasselli AG; Parodi LA; Heinrikson RL; Gurney ME
    Nature; 1999 Dec; 402(6761):533-7. PubMed ID: 10591213
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Development and characterization of beta-secretase monolithic micro-immobilized enzyme reactor for on-line high-performance liquid chromatography studies.
    Mancini F; Naldi M; Cavrini V; Andrisano V
    J Chromatogr A; 2007 Dec; 1175(2):217-26. PubMed ID: 17991476
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
    Sinha S; Anderson JP; Barbour R; Basi GS; Caccavello R; Davis D; Doan M; Dovey HF; Frigon N; Hong J; Jacobson-Croak K; Jewett N; Keim P; Knops J; Lieberburg I; Power M; Tan H; Tatsuno G; Tung J; Schenk D; Seubert P; Suomensaari SM; Wang S; Walker D; Zhao J; McConlogue L; John V
    Nature; 1999 Dec; 402(6761):537-40. PubMed ID: 10591214
    [TBL] [Abstract][Full Text] [Related]  

  • 17. BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
    Farzan M; Schnitzler CE; Vasilieva N; Leung D; Choe H
    Proc Natl Acad Sci U S A; 2000 Aug; 97(17):9712-7. PubMed ID: 10931940
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?
    Nawrot B
    Acta Biochim Pol; 2004; 51(2):431-44. PubMed ID: 15218540
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression.
    Liu K; Doms RW; Lee VM
    Biochemistry; 2002 Mar; 41(9):3128-36. PubMed ID: 11863452
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I; Hawkins J; Harrison D; Hille C; Wayne G; Cutler L; Buck T; Walter D; Demont E; Howes C; Naylor A; Jeffrey P; Gonzalez MI; Dingwall C; Michel A; Redshaw S; Davis JB
    J Neurochem; 2007 Feb; 100(3):802-9. PubMed ID: 17156133
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.