153 related articles for article (PubMed ID: 11179909)
1. Development of a simple and rapid assay for the evaluation of inhibitors of human 17alpha-hydroxylase-C(17,20)-lyase (P450cl7) by coexpression of P450cl7 with NADPH-cytochrome-P450-reductase in Escherichia coli.
Ehmer PB; Jose J; Hartmann RW
J Steroid Biochem Mol Biol; 2000 Dec; 75(1):57-63. PubMed ID: 11179909
[TBL] [Abstract][Full Text] [Related]
2. NADPH-flavodoxin reductase and flavodoxin from Escherichia coli: characteristics as a soluble microsomal P450 reductase.
Jenkins CM; Waterman MR
Biochemistry; 1998 Apr; 37(17):6106-13. PubMed ID: 9558349
[TBL] [Abstract][Full Text] [Related]
3. The function of recombinant cytochrome P450s in intact Escherichia coli cells: the 17 alpha-hydroxylation of progesterone and pregnenolone by P450c17.
Shet MS; Fisher CW; Estabrook RW
Arch Biochem Biophys; 1997 Mar; 339(1):218-25. PubMed ID: 9056252
[TBL] [Abstract][Full Text] [Related]
4. Synthesis of hydroxy derivatives of highly potent non-steroidal CYP 17 inhibitors as potential metabolites and evaluation of their activity by a non cellular assay using recombinant human enzyme.
Hutschenreuter TU; Ehmer PB; Hartmann RW
J Enzyme Inhib Med Chem; 2004 Feb; 19(1):17-32. PubMed ID: 15202489
[TBL] [Abstract][Full Text] [Related]
5. Comparison of the 17 alpha-hydroxylase/C17,20-lyase activities of porcine, guinea pig and bovine P450c17 using purified recombinant fusion proteins containing P450c17 linked to NADPH-P450 reductase.
Shet MS; Fisher CW; Tremblay Y; Belanger A; Conley AJ; Mason JI; Estabrook RW
Drug Metab Rev; 2007; 39(2-3):289-307. PubMed ID: 17786622
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2.
Hartmann RW; Hector M; Haidar S; Ehmer PB; Reichert W; Jose J
J Med Chem; 2000 Nov; 43(22):4266-77. PubMed ID: 11063622
[TBL] [Abstract][Full Text] [Related]
7. Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency.
Imai T; Globerman H; Gertner JM; Kagawa N; Waterman MR
J Biol Chem; 1993 Sep; 268(26):19681-9. PubMed ID: 8396144
[TBL] [Abstract][Full Text] [Related]
8. Cytochrome P450c17-expressing Escherichia coli as a first-step screening system for 17alpha-hydroxylase-C17,20-lyase inhibitors.
Grigoryev DN; Kato K; Njar VC; Long BJ; Ling YZ; Wang X; Mohler J; Brodie AM
Anal Biochem; 1999 Feb; 267(2):319-30. PubMed ID: 10036137
[TBL] [Abstract][Full Text] [Related]
9. Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
Gonzalez E; Guengerich FP
J Biol Chem; 2017 Aug; 292(32):13168-13185. PubMed ID: 28684414
[TBL] [Abstract][Full Text] [Related]
10. Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo.
Haidar S; Ehmer PB; Barassin S; Batzl-Hartmann C; Hartmann RW
J Steroid Biochem Mol Biol; 2003 Apr; 84(5):555-62. PubMed ID: 12767280
[TBL] [Abstract][Full Text] [Related]
11. Regulation of microsomal P450, redox partner proteins, and steroidogenesis in the developing testes of the neonatal pig.
Moran FM; Ford JJ; Corbin CJ; Mapes SM; Njar VC; Brodie AM; Conley AJ
Endocrinology; 2002 Sep; 143(9):3361-9. PubMed ID: 12193548
[TBL] [Abstract][Full Text] [Related]
12. Progesterone metabolism in recombinant yeast simultaneously expressing bovine cytochromes P450c17 (CYP17A1) and P450c21 (CYP21B1) and yeast NADPH-P450 oxidoreductase.
Sakaki T; Akiyoshi-Shibata M; Yabusaki Y; Manabe K; Murakami H; Ohkawa H
Pharmacogenetics; 1991 Nov; 1(2):86-93. PubMed ID: 1844874
[TBL] [Abstract][Full Text] [Related]
13. Hydroxylation of 5 alpha-androstane-3 beta,17 beta-diol by rat prostate microsomes: effects of antibodies and chemical inhibitors of cytochrome P450 enzymes.
Gemzik B; Green J; Parkinson A
Arch Biochem Biophys; 1992 Aug; 296(2):355-65. PubMed ID: 1632629
[TBL] [Abstract][Full Text] [Related]
14. Reconstitution of the enzymatic activities of cytochrome P450s using recombinant flavocytochromes containing rat cytochrome b(5) fused to NADPH--cytochrome P450 reductase with various membrane-binding segments.
Gilep AA; Guryev OL; Usanov SA; Estabrook RW
Arch Biochem Biophys; 2001 Jun; 390(2):215-21. PubMed ID: 11396924
[TBL] [Abstract][Full Text] [Related]
15. Purification and enzymatic properties of a recombinant fusion protein expressed in Escherichia coli containing the domains of bovine P450 17A and rat NADPH-P450 reductase.
Shet MS; Fisher CW; Arlotto MP; Shackleton CH; Holmans PL; Martin-Wixtrom CA; Saeki Y; Estabrook RW
Arch Biochem Biophys; 1994 Jun; 311(2):402-17. PubMed ID: 8203904
[TBL] [Abstract][Full Text] [Related]
16. P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5.
Geller DH; Auchus RJ; Miller WL
Mol Endocrinol; 1999 Jan; 13(1):167-75. PubMed ID: 9892022
[TBL] [Abstract][Full Text] [Related]
17. Purification, characterization, and cDNA cloning of an NADPH-cytochrome P450 reductase from mung bean.
Shet MS; Sathasivan K; Arlotto MA; Mehdy MC; Estabrook RW
Proc Natl Acad Sci U S A; 1993 Apr; 90(7):2890-4. PubMed ID: 8464904
[TBL] [Abstract][Full Text] [Related]
18. A Homodimer Model Can Resolve the Conundrum as to How Cytochrome P450 Oxidoreductase and Cytochrome b5 Compete for the Same Binding Site on Cytochrome P450c17.
Holien JK; Parker MW; Conley AJ; Corbin CJ; Rodgers RJ; Martin LL
Curr Protein Pept Sci; 2017; 18(5):515-521. PubMed ID: 28000554
[TBL] [Abstract][Full Text] [Related]
19. Flavodoxin and NADPH-flavodoxin reductase from Escherichia coli support bovine cytochrome P450c17 hydroxylase activities.
Jenkins CM; Waterman MR
J Biol Chem; 1994 Nov; 269(44):27401-8. PubMed ID: 7961651
[TBL] [Abstract][Full Text] [Related]
20. High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein.
Fisher CW; Shet MS; Caudle DL; Martin-Wixtrom CA; Estabrook RW
Proc Natl Acad Sci U S A; 1992 Nov; 89(22):10817-21. PubMed ID: 1438282
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
