103 related articles for article (PubMed ID: 11206480)
1. Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C.
Ma D; Zhang T; Wang G; Kozikowski AP; Lewin NE; Blumberg PM
Bioorg Med Chem Lett; 2001 Jan; 11(2):99-101. PubMed ID: 11206480
[TBL] [Abstract][Full Text] [Related]
2. Role of the hydrophobic moiety of tumor promoters. Synthesis and activity of 2-alkylated benzolactams.
Endo Y; Yokoyama A
Bioorg Med Chem Lett; 2000 Jan; 10(1):63-6. PubMed ID: 10636245
[TBL] [Abstract][Full Text] [Related]
3. Synthesis of 7-substituted benzolactam-V8s and their selectivity for protein kinase C isozymes.
Ma D; Tang G; Kozikowski AP
Org Lett; 2002 Jul; 4(14):2377-80. PubMed ID: 12098251
[TBL] [Abstract][Full Text] [Related]
4. Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity.
Kozikowski AP; Wang S; Ma D; Yao J; Ahmad S; Glazer RI; Bogi K; Acs P; Modarres S; Lewin NE; Blumberg PM
J Med Chem; 1997 Apr; 40(9):1316-26. PubMed ID: 9135029
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes.
Nakagawa Y; Irie K; Yamanaka N; Ohigashi H; Tsuda K
Bioorg Med Chem Lett; 2003 Sep; 13(18):3015-9. PubMed ID: 12941324
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V.
Nakagawa Y; Irie K; Ohigashi H; Hayashi H; Wender PA
Bioorg Med Chem Lett; 2000 Sep; 10(18):2087-90. PubMed ID: 10999477
[TBL] [Abstract][Full Text] [Related]
7. Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes.
Irie K; Nakagawa Y; Ohigashi H
Curr Pharm Des; 2004; 10(12):1371-85. PubMed ID: 15134488
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and modeling study of (2S,5R,6R)- and (2S,5R,6S)-6-hydroxy- 8-(1-decynyl)-benzolactam-V8 as protein kinase C modulators.
Wei ZL; Sakamuri S; Petukhov PA; George C; Lewin NE; Blumberg PM; Kozikowski AP
Org Lett; 2002 Jun; 4(13):2169-72. PubMed ID: 12074659
[TBL] [Abstract][Full Text] [Related]
9. Structural basis of RasGRP binding to high-affinity PKC ligands.
Rong SB; Enyedy IJ; Qiao L; Zhao L; Ma D; Pearce LL; Lorenzo PS; Stone JC; Blumberg PM; Wang S; Kozikowski AP
J Med Chem; 2002 Feb; 45(4):853-60. PubMed ID: 11831896
[TBL] [Abstract][Full Text] [Related]
10. New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha.
Kozikowski AP; Nowak I; Petukhov PA; Etcheberrigaray R; Mohamed A; Tan M; Lewin N; Hennings H; Pearce LL; Blumberg PM
J Med Chem; 2003 Jan; 46(3):364-73. PubMed ID: 12540236
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and protein kinase C binding activity of benzolactam-V7.
Ma D; Wang G; Wang S; Kozikowski AP; Lewin NE; Blumberg PM
Bioorg Med Chem Lett; 1999 May; 9(10):1371-4. PubMed ID: 10360738
[TBL] [Abstract][Full Text] [Related]
12. Twist form of teleocidin derivatives is active in in vivo tumor promotion by (-)-benzolactam-V8-310.
Okabe S; Sueoka N; Komori A; Suganuma M; Endo Y; Shudo K; Fujiki H
Biol Pharm Bull; 1998 May; 21(5):465-8. PubMed ID: 9635501
[TBL] [Abstract][Full Text] [Related]
13. The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities.
Nakagawa Y; Irie K; Nakamura Y; Ohigashi H
Bioorg Med Chem Lett; 2001 Mar; 11(5):723-8. PubMed ID: 11266178
[TBL] [Abstract][Full Text] [Related]
14. Clarification of the binding mode of teleocidin and benzolactams to the Cys2 domain of protein kinase Cdelta by synthesis of hydrophobically modified, teleocidin-mimicking benzolactams and computational docking simulation.
Endo Y; Takehana S; Ohno M; Driedger PE; Stabel S; Mizutani MY; Tomioka N; Itai A; Shudo K
J Med Chem; 1998 Apr; 41(9):1476-96. PubMed ID: 9554881
[TBL] [Abstract][Full Text] [Related]
15. Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity.
Irie K; Nakahara A; Nakagawa Y; Ohigashi H; Shindo M; Fukuda H; Konishi H; Kikkawa U; Kashiwagi K; Saito N
Pharmacol Ther; 2002; 93(2-3):271-81. PubMed ID: 12191619
[TBL] [Abstract][Full Text] [Related]
16. Synthesis, computer modeling and biological evaluation of novel protein kinase C agonists based on a 7-membered lactam moiety.
Endo Y; Shimazu M; Fukasawa H; Driedger PE; Kimura K; Tomioka N; Itai A; Shudo K
Bioorg Med Chem Lett; 1999 Jan; 9(2):173-8. PubMed ID: 10021922
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and pharmacological evaluation of 8- and 9-substituted benzolactam-v8 derivatives as potent ligands for protein kinase C, a therapeutic target for Alzheimer's disease.
Mach UR; Lewin NE; Blumberg PM; Kozikowski AP
ChemMedChem; 2006 Mar; 1(3):307-14. PubMed ID: 16892365
[TBL] [Abstract][Full Text] [Related]
18. Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta.
Nakagawa Y; Irie K; Yanagita RC; Ohigashi H; Tsuda K; Kashiwagi K; Saito N
J Med Chem; 2006 May; 49(9):2681-8. PubMed ID: 16640328
[TBL] [Abstract][Full Text] [Related]
19. New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity.
Sridhar J; Wei ZL; Nowak I; Lewin NE; Ayres JA; Pearce LV; Blumberg PM; Kozikowski AP
J Med Chem; 2003 Sep; 46(19):4196-204. PubMed ID: 12954072
[TBL] [Abstract][Full Text] [Related]
20. Solid-phase synthesis and biological evaluation of a teleocidin library--discovery of a selective PKCdelta down regulator.
Meseguer B; Alonso-Díaz D; Griebenow N; Herget T; Waldmann H
Chemistry; 2000 Nov; 6(21):3943-57. PubMed ID: 11126955
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
